4.4 Review

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

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Article Pharmacology & Pharmacy

Effect of hepar-protecting Wuzhi capsule on pharmacokinetics and dose-effect character of tacrolimus in healthy volunteers

Fei Teng et al.

Summary: This study investigated the dose-effect relationship between WZC and tacrolimus, as well as the influence of CYP3A5 and MDR1 genetic polymorphisms on the dosage of WZC. The results showed that when co-administered with WZC, the T-max of tacrolimus was increased significantly while the apparent oral clearance was decreased. The plasma tacrolimus level was much lower in volunteers with high CYP3A5 expression compared to those with mutant CYP3A5. However, polymorphisms of MDR1 were not associated with plasma tacrolimus levels.

BIOPHARMACEUTICS & DRUG DISPOSITION (2022)

Article Medicine, Research & Experimental

A phase I evaluation of the effect of curcumin on dose-limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors

Olumide B. Gbolahan et al.

Summary: This study aimed to evaluate the safety and efficacy of concurrent administration of curcumin and irinotecan. The results showed that the combination therapy was well-tolerated and did not significantly affect the pharmacokinetic properties of irinotecan. There was no apparent increase in the incidence of toxicities associated with irinotecan. Although the objective response rate was relatively low, further studies are needed to evaluate the efficacy of this combination therapy.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2022)

Article Medicine, Research & Experimental

The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis

G. D. Marijn Veerman et al.

Summary: The concomitant use of green tea extract with nintedanib may result in a clinically relevant drug interaction, leading to a 21% decrease in nintedanib exposure. Additional clinical validation is necessary to determine the impact of this interaction on treatment efficacy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Oncology

A Phase II Clinical Trial on the Combination Therapy of PHY906 Plus Capecitabine in Hepatocellular Carcinoma

Chun A. Changou et al.

Summary: The combination of PHY906 and capecitabine showed effectiveness as salvage therapy for HCC patients with previous systemic treatments. It can improve clinical outcomes and reduce side effects, with better outcomes observed in patients who had not received previous chemotherapies or targeted therapy, had lower starting AFP levels, or had HBV infection.

ONCOLOGIST (2021)

Review Pharmacology & Pharmacy

Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach

Emily J. Cox et al.

Summary: The article discusses the potential risks of botanical drugs on drug metabolism and provides a method for developing and applying models for pharmacokinetic interactions.

PHARMACOLOGICAL REVIEWS (2021)

Article Pharmacology & Pharmacy

Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation

Md Masud Parvez et al.

Summary: The metabolism and uptake processes of irinotecan in the body determine its toxic effects in the intestine and liver, primarily controlled by hydrolysis mediated by carboxylesterase and glucuronidation. The study's results are important for explaining the characteristic intestinal exposure and toxicity of irinotecan.

DRUG METABOLISM AND DISPOSITION (2021)

Article Pharmacology & Pharmacy

Effects and safety evaluation of Wuzhi Capsules combined with tacrolimus for the treatment of kidney transplantation recipients

Fang Cheng et al.

Summary: Wuzhi capsule can increase tacrolimus concentration without negative effects on renal function and adverse reactions, especially in CYP3A5 expressers.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2021)

Review Pharmacology & Pharmacy

Clinical relevance of St. John's wort drug interactions revisited

Simon Nicolussi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Genetics & Heredity

Drug-drug-gene interactions and adverse drug reactions

Mustafa Adnan Malki et al.

PHARMACOGENOMICS JOURNAL (2020)

Review Pharmacology & Pharmacy

Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content

Sigrun Chrubasik-Hausmann et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Pharmacodynamic Drug-Drug Interactions

Jin Niu et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

Review Nutrition & Dietetics

Curcumin and Cancer

Antonio Giordano et al.

NUTRIENTS (2019)

Article Integrative & Complementary Medicine

An evaluation of garlic products available in Australian pharmacies-From the label to the laboratory

Wai-Jo Jocelin Chan et al.

JOURNAL OF HERBAL MEDICINE (2018)

Article Integrative & Complementary Medicine

Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy

Jiang Shu-long et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2017)

Review Biochemistry & Molecular Biology

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

Jeffry Adiwidjaja et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2017)

Article Medicine, General & Internal

Complementary medicine products: interpreting the evidence base

Marc Cohen et al.

INTERNAL MEDICINE JOURNAL (2017)

Article Pharmacology & Pharmacy

Mechanisms and Consequences of Drug-Drug Interactions

David J. Greenblatt

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2017)

Article Pharmacology & Pharmacy

The Effect of St John's Wort on the Pharmacokinetics of Docetaxel

Andrew K. L. Goey et al.

CLINICAL PHARMACOKINETICS (2014)

Article Pharmacology & Pharmacy

Herb-Drug Interactions: Challenges and Opportunities for Improved Predictions

Scott J. Brantley et al.

DRUG METABOLISM AND DISPOSITION (2014)

Article Pharmacology & Pharmacy

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel

Andrew K. L. Goey et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Article Integrative & Complementary Medicine

NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors

Patrick J. Mansky et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Oncology

Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C2

Debra L. Barton et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Biotechnology & Applied Microbiology

PharmGKB summary: tamoxifen pathway, pharmacokinetics

Daniel J. Klein et al.

PHARMACOGENETICS AND GENOMICS (2013)

Review Chemistry, Medicinal

Herbal medicines: old and new concepts, truths and misunderstandings

Fabio Carmona et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2013)

Article Pharmacology & Pharmacy

A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects

Ruidong Li et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion-Transporting Polypeptides

M. J. Dolton et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)

Article Oncology

Marginal increase of sunitinib exposure by grapefruit juice

Nielka P. van Erp et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Effect of Citrus Juice and SLCO2B1 Genotype on the Pharmacokinetics of Montelukast

E. B. Mougey et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2011)

Article Biotechnology & Applied Microbiology

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

Junko Imanaga et al.

PHARMACOGENETICS AND GENOMICS (2011)

Article Pharmacology & Pharmacy

Effect of Grapefruit Juice on the Pharmacokinetics of Nilotinib in Healthy Participants

Ophelia Q. P. Yin et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2010)

Article Cell Biology

The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity

Wing Lam et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Review Biochemistry & Molecular Biology

Tyrosine Kinase Inhibitors - A Review on Pharmacology, Metabolism and Side Effects

Joerg Thomas Hartmann et al.

CURRENT DRUG METABOLISM (2009)

Article Pharmacology & Pharmacy

Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers

Hua-Wen Xin et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2007)

Article Oncology

Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel

Michael C. Cox et al.

CLINICAL CANCER RESEARCH (2006)

Review Pharmacology & Pharmacy

Clinical pharmalcokinetics of docetaxel - Recent developments

SD Baker et al.

CLINICAL PHARMACOKINETICS (2006)

Article Oncology

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

NPH van Erp et al.

CLINICAL CANCER RESEARCH (2005)

Review Biochemistry & Molecular Biology

Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity

E Fontana et al.

CURRENT DRUG METABOLISM (2005)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of imatinib

B Peng et al.

CLINICAL PHARMACOKINETICS (2005)

Article Pharmacology & Pharmacy

Effect of St John's wort on imatinib mesylate pharmacokinetics

RF Frye et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)

Review Biochemistry & Molecular Biology

Herb-drug interactions: An evidence based approach

PD Coxeter et al.

CURRENT MEDICINAL CHEMISTRY (2004)

Review Pharmacology & Pharmacy

Impact of drug transporter studies on drug discovery and development

N Mizuno et al.

PHARMACOLOGICAL REVIEWS (2003)

Article Pharmacology & Pharmacy

Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice

ML Veronese et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2003)

Article Immunology

Sirolimus: Its discovery, biological properties, and mechanism of action

SN Sehgal

TRANSPLANTATION PROCEEDINGS (2003)

Review Pharmacology & Pharmacy

Role of P-glycoprotein in pharmacokinetics - Clinical implications

JH Lin et al.

CLINICAL PHARMACOKINETICS (2003)

Article Pharmacology & Pharmacy

Effect of grapefruit juice intake on etoposide bioavailability

S Reif et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2002)

Article Pharmacology & Pharmacy

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

D Dürr et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2000)