4.8 Article

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Hyperprogressive disease rarely occurs during checkpoint inhibitor treatment for advanced melanoma

M. Schuiveling et al.

Summary: Hypperprogression, characterized by rapid acceleration in tumor growth, is rare in melanoma patients treated with immune checkpoint inhibitors. The data raises questions about whether hyperprogression is truly a biological entity in metastatic melanoma.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Immunology

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan et al.

Summary: Studies have shown that PD-1-deficient T reg cells exhibit enhanced immunosuppressive function through reduced signaling through the PI3K-AKT pathway. This finding demonstrates that cell-intrinsic PD-1 restraint of T reg cells is a significant mechanism by which PD-1 inhibitory signals regulate T cell tolerance and autoimmunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Jiali Yu et al.

Summary: Liver metastases diminish the efficacy of immunotherapy by siphoning activated CD8(+) T cells from systemic circulation, creating systemic immune desert. Combining liver-directed radiotherapy with immunotherapy can promote systemic antitumor immunity.

NATURE MEDICINE (2021)

Review Oncology

Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy

Christopher Tay et al.

Summary: PD-1 blockade therapy has shown success in fighting cancer by activating immune cells, but it may have negative effects on Tregs, potentially causing hyper-progressive disease in some patients.

CANCERS (2021)

Article Oncology

Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation

Wan Du et al.

Summary: Mutations in IFN and MHC signaling genes contribute to immunotherapy resistance, particularly in colorectal cancer. Loss of optineurin impairs the integrity of both IFN and MHC-I signaling pathways, leading to immune evasion and intrinsic immunotherapy resistance in colorectal cancer. Pharmacologically targeting IFNGR1 palmitoylation shows promise in enhancing tumor immunity and sensitizing checkpoint therapy in colorectal cancer.

CANCER DISCOVERY (2021)

Article Cell Biology

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy

Gaopeng Li et al.

Summary: Li et al. identified a lncRNA called LIMIT that regulates MHC-I expression through HSP90 and HSF1, impacting antitumour immune response and immunotherapy efficacy. By activating GBPs and MHC-I, LIMIT enhances tumour immunogenicity and boosts the effectiveness of immunotherapy.

NATURE CELL BIOLOGY (2021)

Review Medicine, General & Internal

Definition, Incidence, and Challenges for Assessment of Hyperprogressive Disease During Cancer Treatment With Immune Checkpoint Inhibitors A Systematic Review and Meta-analysis

Hyo Jung Park et al.

Summary: HPD is a recognized pattern of rapid tumor progression during immune checkpoint inhibitor treatment. The incidence of HPD varies from 5.9% to 43.1% across studies examined. Definitions of HPD are diverse, indicating the need for establishing uniform criteria based on currently available evidence.

JAMA NETWORK OPEN (2021)

Article Oncology

Hyperprogression after nivolumab for melanoma: A case report

Mesut Yilmaz et al.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2020)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

FDG PET Findings of Hyperprogression During Immunotherapy in a Patient With Hepatocellular Carcinoma

Jingnan Wang et al.

CLINICAL NUCLEAR MEDICINE (2020)

Article Medicine, Research & Experimental

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

Jing Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Oncology

Immunotherapy discontinuation - how, and when? Data from melanoma as a paradigm

Caroline Robert et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Oncology

PAK4 inhibition improves PD-1 blockade immunotherapy

Gabriel Abril-Rodriguez et al.

NATURE CANCER (2020)

Letter Dermatology

BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade

Neda Nikbakht et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Anna M. Paczulla et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E. Yost et al.

NATURE MEDICINE (2019)

Article Medicine, General & Internal

Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma

Y. Loriot et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega et al.

Correction Medicine, Research & Experimental

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression (vol 128, pg 805, 2018)

Heng Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Immunology

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

Flavia Castro et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Oncology

Impact of oncogenic pathways on evasion of antitumour immune responses

Stefani Spranger et al.

NATURE REVIEWS CANCER (2018)

Article Oncology

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade

Tavi Nathanson et al.

CANCER IMMUNOLOGY RESEARCH (2017)

Article Multidisciplinary Sciences

Integrative clinical genomics of metastatic cancer

Dan R. Robinson et al.

NATURE (2017)

Article Multidisciplinary Sciences

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Nadeem Riaz et al.

Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Oncology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Suzanne L. Topalian et al.

CANCER CELL (2015)

Article Biochemistry & Molecular Biology

Integrative Clinical Genomics of Advanced Prostate Cancer

Dan Robinson et al.

Article Biochemistry & Molecular Biology

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

Naoki Oshimori et al.

Editorial Material Oncology

Pseudoprogression and Immune-Related Response in Solid Tumors

Victoria L. Chiou et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Multidisciplinary Sciences

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Stefani Spranger et al.

NATURE (2015)

Article Multidisciplinary Sciences

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Eliezer M. Van Allen et al.

SCIENCE (2015)

Review Cell Biology

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai et al.

TRENDS IN CELL BIOLOGY (2014)

Article Medicine, Research & Experimental

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

Petra Simic et al.

EMBO MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer

Ana Chocarro-Calvo et al.

MOLECULAR CELL (2013)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Article Multidisciplinary Sciences

A restricted cell population propagates glioblastoma growth after chemotherapy

Jian Chen et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou et al.

NATURE CHEMICAL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang et al.

NATURE (2011)

Article Multidisciplinary Sciences

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

Alexander D. Boiko et al.

NATURE (2010)

Review Oncology

Fibroblast growth factor signalling: from development to cancer

Nicholas Turner et al.

NATURE REVIEWS CANCER (2010)

Review Cell Biology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Bryan T. MacDonald et al.

DEVELOPMENTAL CELL (2009)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Article Biochemistry & Molecular Biology

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

E. Lara et al.

ONCOGENE (2009)

Article Biochemistry & Molecular Biology

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi et al.

SCIENCE SIGNALING (2009)

Review Genetics & Heredity

Epidermal growth factor receptor (EGFR) signaling in cancer

N Normanno et al.

Review Oncology

Why do cancers have high aerobic glycolysis?

RA Gatenby et al.

NATURE REVIEWS CANCER (2004)

Article Biochemistry & Molecular Biology

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

TJ Curiel et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Acetylation of β-catenin by CREB-binding protein (CBP)

D Wolf et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.