4.8 Article

IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Clonal germinal center B cells function as a niche for T-cell lymphoma

Manabu Fujisawa et al.

Summary: This study investigates the mechanism by which TET2-mutant immune cells enable the development of Angioimmunoblastic T-cell lymphoma (AITL). The results reveal that Tet2-deficient immune cells play a crucial role in AITL development, and aberrant GCB cells in AITL undergo clonal evolution with recurrent mutations in genes related to core histones. Cd40-Cd40lg is identified as a possible mediator of interactions between GCB and tumor cell clusters.
Article Multidisciplinary Sciences

Oncometabolite D-2HG alters T cell metabolism to impair CD8(+) T cell function

Giulia Notarangelo et al.

Summary: Gain-of-function mutations in IDH result in the production of oncometabolite D-2HG, which promotes tumorigenesis by affecting the metabolism and antitumor functions of CD8(+) T cells.

SCIENCE (2022)

Article Biochemistry & Molecular Biology

Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells

Ha Thi Thu Do et al.

Summary: The study revealed that XCL1 enhances cell migration and epithelial-mesenchymal transition in breast cancer cells MDA-MB-231 and SK-BR-3 through the activation of ERK/HIF-1α/EMT signaling pathway. The XCL1-XCR1 interaction may serve as a specific target for preventing breast cancer cell migration and metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

Raud Razzaghi et al.

Summary: The study indicates that Fas serves as an intrinsic regulator in GC B cells and plays a crucial role in maintaining GC homeostasis. Mutations in FAS are associated with poor prognosis, enrichment of Tfh cells, and deficiencies in HVEM and PD-L1 in GC-derived DLBCL.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation

Siyuan Wan et al.

Summary: The study revealed that PMA + ionomycin stimulation combined with IL-6 can induce Tfh cell-like transcriptomic programs in vitro, and inhibition of ERK2 can enhance Tfh cell development. Additionally, ICOS lacks the ability to activate ERK, while Zfp831 promotes Tfh cell differentiation by upregulating the expression of Bcl6 and Tcf7.

IMMUNITY (2021)

Article Hematology

Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma

Francois Lemonnier et al.

Summary: The combination of lenalidomide and CHOP did not improve the complete metabolic response in AITL patients. The study identified specific mutations associated with distinct pathological and clinical features in AITL.

BLOOD ADVANCES (2021)

Review Immunology

Cytokine-skewed Tfh cells: functional consequences for B cell help

Adesola C. Olatunde et al.

Summary: Tfh cells are crucial for providing help for B cells in germinal centers, contributing to effective and long-lasting humoral immune responses. The cytokine-skewed differentiation and functions of Tfh cells play a significant role in modulating disease progression and humoral immune responses.

TRENDS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Transcription factor RUNX3 promotes CD8+ T cell recruitment by CCL3 and CCL20 in lung adenocarcinoma immune microenvironment

Qian Song et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Article Peripheral Vascular Disease

Interleukin-22 promotes tumor angiogenesis

Nicholas J. Protopsaltis et al.

ANGIOGENESIS (2019)

Article Biochemistry & Molecular Biology

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

Lukas Bunse et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation

Wei-Chan Hsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Medicine, Research & Experimental

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis

Shengbing Zang et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemical Research Methods

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

M. Ryan Corces et al.

NATURE METHODS (2017)

Article Oncology

Identification of cell-type-specific mutations in nodal T-cell lymphomas

T. B. Nguyen et al.

BLOOD CANCER JOURNAL (2017)

Editorial Material Immunology

Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells

Simon Belanger et al.

NATURE IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Francois Lemonnier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Batf is important for IL-4 expression in T follicular helper cells

Anupama Sahoo et al.

NATURE COMMUNICATIONS (2015)

Article Genetics & Heredity

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

Mamiko Sakata-Yanagimoto et al.

NATURE GENETICS (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Immunology

PD-1 is a novel regulator of human B-cell activation

Marie-Laure Thibult et al.

INTERNATIONAL IMMUNOLOGY (2013)

Letter Medicine, General & Internal

TET2 and DNMT3A Mutations in Human T-Cell Lymphoma

Lucile Couronne et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Meeting Abstract Rheumatology

IMPAIRED B CELL IMMUNITY IN IL-22 KNOCK-OUT MICE IN COLLAGEN INDUCED ARTHRITIS

Odilia Corneth et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Editorial Material Hematology

A novel subset of T-helper cells: follicular T-helper cells and their markers

Camille Laurent et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)

Review Biochemistry & Molecular Biology

DNA methylation and chromatin - unraveling the tangled web

KD Robertson

ONCOGENE (2002)