Subclonal mutations in epigenetic regulators bring fitness in times of stress

Mutations in epigenetic regulators are prevalent in cancer, but their functional impact is poorly delineated aside from disrupting differentiation. In this issue of Cancer Cell, Loukas et al. zoom in on the late occurring, subclonal subset of such mutations and define the molecular mechanism behind their enrichment in cancer.

Automated summary

Mutations in epigenetic regulators are common in cancer, but their functional impact beyond differentiation disruption is not well understood. In this issue of Cancer Cell, Loukas et al. investigate the late occurring, subclonal subset of these mutations and identify the molecular mechanism that leads to their enrichment in cancer.