The regulatory role of non-coding RNAs and their interactions with phytochemicals in neurodegenerative diseases: a systematic review

Neurodegenerative diseases (NDDs) are on the rise in the world. Therefore, it is a critical issue to reveal the precise pathophysiological mechanisms and novel therapeutic strategies to deal with such conditions. Passing through different mechanisms, non-coding RNAs (ncRNAs) play a pivotal role in NDDs through various mechanisms, by changing the expression of some genes, interference with protein translation and alterations in some signaling pathways. It urges the need to introduce novel strategies and therapeutic agents with multi-targeting potentials. Phytochemicals are hopeful antioxidants and anti-inflammatory agents with promising modulatory roles on dysregulated signaling pathways and protein translation during NDDs. In this study, the role of ncRNAs (e.g. lncRNAs, miRNA, siRNAs and piRNAs) was highlighted in NDDs. This study also aimed to investigate the role of phytochemicals (phenolic compounds, alkaloids, terpenoids and sulfur compounds) in the modulation of ncRNAs during NDDs such as Alzheimer's disease, Parkinson's disease, epilepsy, depression and amyotrophic lateral sclerosis.

Automated summary

Neurodegenerative diseases are increasing globally, making it crucial to uncover the precise pathophysiological mechanisms and develop novel therapeutic strategies. Non-coding RNAs play a pivotal role in these diseases through various mechanisms, such as gene expression modulation, protein translation interference, and alterations in signaling pathways. The study highlights the role of different ncRNAs and investigates how phytochemicals can modulate ncRNAs in neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, epilepsy, depression, and amyotrophic lateral sclerosis.