4.7 Review

From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies?

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Summary: ancMETA, a Bayesian graph-based framework, shows promise in increasing statistical power for meta-analysis of genetic variants underlying complex diseases by deconvoluting gene interactions across human populations. Combining SNPs within genes and genes from multiple GWAS studies helps identify associations with small effect sizes and increases association power. The framework may offer new insights into the genetic basis of diseases and ethnic differences.

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