期刊
BRAIN RESEARCH
卷 1797, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.brainres.2022.148116
关键词
Mitochondrial unfolded protein response; Ischemia-reperfusion injury; Mitochondrial dysfunction; Mitochondrial homeostasis
资金
- National Natural Science Founda-tion of China
- Natural Science Foundation of Heilongjiang Province
- [82001386]
- [82201482]
- [YQ2020H021]
This article discusses the regulatory mechanisms of mitochondrial unfolded protein response (UPRmt) in ischemia-reperfusion injury and reviews the recent studies on the roles and mechanisms of UPRmt signaling in heart, brain, kidney, and liver ischemia-reperfusion injury.
Mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that activates the tran-scriptional program of mitochondrial chaperone proteins and proteases to keep protein homeostasis in mito-chondria. Ischemia-reperfusion injury results in multiple severe clinical issues linked to high morbidity and mortality in various disorders. The pathophysiology and pathogenesis of ischemia-reperfusion injury are com-plex and multifactorial. Emerging evidence showed the roles of UPRmt signaling in ischemia-reperfusion injury. Herein, we discuss the regulatory mechanisms underlying UPRmt signaling in C. elegans and mammals. Furthermore, we review the recent studies into the roles and mechanisms of UPRmt signaling in ische-mia-reperfusion injury of the heart, brain, kidney, and liver. Further research of UPRmt signaling will potentially develop novel therapeutic strategies against ischemia-reperfusion injury.
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