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The fate of interneurons, GABAA receptor sub-types and perineuronal nets in Alzheimer's disease

BRAIN PATHOLOGY (2023)

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Summary: The presubiculum (PRS) is a resilient region in clinical Alzheimer's disease, showing minimal signs of AD compared to neighboring components of the perforant pathway. The unique spatial profile of the PRS correlates with the preservation of principal pyramidal cell properties, in contrast to the altered properties observed in the entorhinal cortex and hippocampal CA1. Understanding the mechanisms underlying this resilience could be important for preventing cognitive deficits in AD.

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Article Pharmacology & Pharmacy

Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model

Yousif Aldabbagh et al.

Summary: In this study, the researchers investigated the alteration of astrocyte-specific GABA transporter 3/4 (GAT3/4) in a mouse model of Alzheimer's disease (AD) and its correlation with changes in excitability of principal cells. They found increased expression of GAT3/4 in reactive astrocytes in the hippocampus of AD mice, which was correlated with enhanced tonic inhibition. Blocking GAT3/4 resulted in increased excitability of principal cells in both wild-type and AD mice, exacerbating synaptic hyperactivity. This suggests that reducing tonic inhibition through GAT3/4 may not be an effective therapeutic strategy for AD.

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Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer's mouse model

Christophe Clement Rey et al.

Summary: The study found that decreased presence of PNN around PV cells in Alzheimer's disease mouse models is associated with social memory deficits. Single local injection of the growth factor NRG1 can restore both PV/PNN levels and social memory performance of these mice.

ISCIENCE (2022)

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Article Clinical Neurology

Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain

Aric F. Logsdon et al.

Summary: The study found that patients with AD-related dementia experience a re-coding of their PNN-associated CS-GAGs, correlating with the progression of pathology, accumulation of p-tau, and cognitive impairment. These sulfation changes can be detected prior to classical AD pathology, potentially playing a crucial role in the development of the disease.

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Review Neurosciences

Functional Neurophysiological Biomarkers of Early-Stage Alzheimer's Disease: A Perspective of Network Hyperexcitability in Disease Progression

Sean Tok et al.

Summary: Network hyperexcitability has been suggested as a potential neurophysiological indicator of Alzheimer's disease. It has been demonstrated in animal models and patients with AD, and several hypotheses have been proposed to explain its prevalence. Developing animal models with AD-specific NH could aid in the discovery and development of novel therapies for AD.

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Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction

Elise C. Cope et al.

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The Loss of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight?

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Parvalbumin interneuron vulnerability and brain disorders

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Electrophysiological Biomarkers of Epileptogenicity in Alzheimer's Disease

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Summary: Cortical network hyperexcitability is a common feature in Alzheimer's disease patients, with seizures reported in a significant portion of them. Detecting and intervening in this hyperexcitability can potentially slow down cognitive decline in AD patients. Various techniques such as EEG and MEG play crucial roles in detecting epileptic activities in AD patients.

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Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer's Disease

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Perineuronal Net Dynamics in the Pathophysiology of Epilepsy

Lata Chaunsali et al.

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Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors

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Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease

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Is loss of perineuronal nets a critical pathological event in Alzheimer's disease?

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Hippocampal α5 subunit-containing GABAA receptors are involved in the development of the latent inhibition effect

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NEUROBIOLOGY OF LEARNING AND MEMORY (2008)

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Review Pharmacology & Pharmacy

International union of pharmacology.: LXX.: Subtypes of γ-aminobutyric AcidA receptors:: Classification on the basis of subunit composition, pharmacology, and function.: Update

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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

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SCIENCE (2008)

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Review Multidisciplinary Sciences

Neuronal diversity and temporal dynamics: The unity of hippocampal circuit operations

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SCIENCE (2008)

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

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TRENDS IN NEUROSCIENCES (2008)

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Synaptic α5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex

Afia B. Ali et al.

CEREBRAL CORTEX (2008)

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Review Biochemistry & Molecular Biology

GABAA receptors in aging and Alzheimer's disease

Robert A. Rissman et al.

JOURNAL OF NEUROCHEMISTRY (2007)

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Review Neurosciences

Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets

Iryna M. Ethell et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

Jorge J. Palop et al.

NEURON (2007)

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Altered localization of GABAA receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy

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JOURNAL OF NEUROSCIENCE (2007)

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Review Neurosciences

Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla et al.

NATURE REVIEWS NEUROSCIENCE (2007)

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Review Cell Biology

Calcium and neurodegeneration

Mark P. Mattson

AGING CELL (2007)

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Perineuronal nets protect against amyloid β-protein neurotoxicity in cultured cortical neurons

Seiji Miyata et al.

BRAIN RESEARCH (2007)

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GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states

John C. Earnheart et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Geriatrics & Gerontology

Early-onset Alzheimer's disease is associated with greater pathologic burden

Gad A. Marshall et al.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2007)

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Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes

Annalisa Bernareggi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Neurosciences

The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

Clare M. Galtrey et al.

BRAIN RESEARCH REVIEWS (2007)

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Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABAA receptor α5 subunit-deficient mice

J Glykys et al.

JOURNAL OF NEUROPHYSIOLOGY (2006)

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Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptorβ1 subunit

MM Huntsman et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

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An inverse agonist selective for α5 subunit-containing GABAA receptors enhances cognition

GR Dawson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

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GABA regulates synaptic integration of newly generated neurons in the adult brain

SY Ge et al.

NATURE (2006)

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Review Pharmacology & Pharmacy

GABA(A) receptor subtypes as targets for neuropsychiatric drug development

ER Korpi et al.

PHARMACOLOGY & THERAPEUTICS (2006)

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GABAA receptor-mediated tonic inhibition in thalamic neurons

DW Cope et al.

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Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus

A Scimemi et al.

JOURNAL OF NEUROSCIENCE (2005)

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Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations

T Klausberger et al.

JOURNAL OF NEUROSCIENCE (2005)

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Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease

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ACTA NEUROPATHOLOGICA (2005)

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Variations on an inhibitory theme:: Phasic and tonic activation of GABAA receptors

M Farrant et al.

NATURE REVIEWS NEUROSCIENCE (2005)

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GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum

SH Fatemi et al.

SCHIZOPHRENIA RESEARCH (2005)

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Neuro-modulation, aminergic neuro-disinhibition and neuro-degeneration. Draft of a comprehensive theory for Alzheimer disease

HP Schmitt

MEDICAL HYPOTHESES (2005)

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Defined types of cortical interneurone structure space and spike timing in the hippocampus

P Somogyi et al.

JOURNAL OF PHYSIOLOGY-LONDON (2005)

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α5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro

SK Towers et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

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Article Biochemistry & Molecular Biology

Subregional analysis of GABAA receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment

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JOURNAL OF CHEMICAL NEUROANATOMY (2004)

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Requirement of α5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice

C van Rijnsoever et al.

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An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA α5 receptors with cognition enhancing properties

MS Chambers et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

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GABAA receptors containing the α5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear

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EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

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Interneurons of the neocortical inhibitory system

H Markram et al.

NATURE REVIEWS NEUROSCIENCE (2004)

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Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology

RA Rissman et al.

NEUROSCIENCE (2003)

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The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation

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HIPPOCAMPUS (2003)

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Review Clinical Neurology

The glutamatergic system and Alzheimer's disease - Therapeutic implications

DA Butterfield et al.

CNS DRUGS (2003)

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General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit

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FASEB JOURNAL (2002)

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Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices

SH Fatemi et al.

BIOLOGICAL PSYCHIATRY (2002)

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Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

N Brown et al.

BRITISH JOURNAL OF PHARMACOLOGY (2002)

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Trace fear conditioning involves hippocampal α5 GABAA receptors

F Crestani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder -: A postmortem brain study

A Guidotti et al.

ARCHIVES OF GENERAL PSYCHIATRY (2000)

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Sedative but not anxiolytic properties of benzodiazepines ave mediated by the GABAA receptor α1 subtype

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NATURE NEUROSCIENCE (2000)

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Perineuronal nets ensheath fast spiking, parvalbumin-immunoreactive neurons in the medial septum/diagonal band complex

NP Morris et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2000)

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Density and pharmacology of alpha 5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients

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