Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

Article Clinical Neurology

A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis

Reza Rahmanzadeh et al.

Summary: This study demonstrates the possibility of distinguishing chronic lesions in multiple sclerosis in a clinical setting and provides support for the development and assessment of remyelinating treatments using new biomarkers.

ANNALS OF NEUROLOGY (2022)

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Article Clinical Neurology

Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter

Antonio Luchicchi et al.

Summary: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of unknown etiology. Recent studies suggest that autoimmunity may be a secondary reaction to idiopathic brain damage in MS, leading to an impaired interaction between myelin and axons. This imbalance may result in myelin disintegration and subsequent immune attack in MS, as indicated by changes in molecular and morphological alterations detected in the brains of MS patients.

ANNALS OF NEUROLOGY (2021)

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Review Neurosciences

Myelin quantification with MRI: A systematic review of accuracy and reproducibility

Chris W. J. van der Weijden et al.

Summary: This systematic review examines the performance of MRI methods for myelin quantification, showing a fairly good correlation with histology and good reproducibility. However, due to limited validation data and variability in performance between studies, the optimal MRI method for myelin quantification has yet to be determined.

NEUROIMAGE (2021)

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Article Clinical Neurology

QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions

Kelly M. Gillen et al.

Summary: This study characterized the histopathological correlates of different QSM hyperintensity patterns in MS lesions, finding that high QSM signal at the lesion perimeter is associated with activated iron(+) myeloid cells, while lesions with high punctate or homogenous QSM signal contain no or minimally activated iron(-) myeloid cells. The research suggests that a high QSM signal outlining the lesion rim is a biomarker for chronic inflammation in white matter lesions.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

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Review Clinical Neurology

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

Cristina Granziera et al.

Summary: Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, allowing comparisons across different regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques offer insight into disease mechanisms beyond what traditional MRI can provide, including assessment of diffuse damage, heterogeneity of lesions, and specific damage to CNS tissues. Emerging applications of quantitative MRI in both research and clinical settings aim to improve patient stratification, assess disease progression, and evaluate treatment response.

BRAIN (2021)

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Review Neurosciences

Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology

Alberto Lazari et al.

Summary: The study conducted a systematic review and meta-analysis on MRI-based myelin markers, finding correlations between various myelin histology metrics and markers from different MRI modalities, but no single most sensitive strategy to measure myelin with MRI. The authors provided a detailed characterization of the evaluated studies and 12 recommendations for future research.

NEUROIMAGE (2021)

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Article Clinical Neurology

7T MRI Differentiates Remyelinated from Demyelinated Multiple Sclerosis Lesions

Hadar Kolb et al.

Summary: This study developed a simple classification scheme based on T1 relaxation time maps for noninvasive assessment of myelin status in chronic white matter lesions of MS. The results showed that long-T1 and mixed-T1 lesions were mainly distributed in juxtacortical and periventricular white matter regions, while short-T1 lesions were more common in deep white matter areas.

ANNALS OF NEUROLOGY (2021)

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Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

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Article Clinical Neurology

Value of 3T Susceptibility-Weighted Imaging in the Diagnosis of Multiple Sclerosis

M. A. Clarke et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2020)

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Article Clinical Neurology

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Pietro Maggi et al.

ANNALS OF NEUROLOGY (2020)

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Histopathology-validated recommendations for cortical lesion imaging in multiple sclerosis

Piet M. Bouman et al.

BRAIN (2020)

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An interactive meta-analysis of MRI biomarkers of myelin

Matteo Mancini et al.

ELIFE (2020)

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Imaging outcome measures of neuroprotection and repair in MS

Jiwon Oh et al.

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The influence of brain iron on myelin water imaging

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Axonal degeneration as substrate of fractional anisotropy abnormalities in multiple sclerosis cortex

Paolo Preziosa et al.

BRAIN (2019)

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Imaging the multiple sclerosis lesion: insights into pathogenesis, progression and repair

Chenyu Tim Wang et al.

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MYELIN IN THE CENTRAL NERVOUS SYSTEM: STRUCTURE, FUNCTION, AND PATHOLOGY

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Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Martina Absinta et al.

JAMA NEUROLOGY (2019)

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Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury

Allison D. Griffin et al.

BRAIN (2019)

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hMRI - A toolbox for quantitative MRI in neuroscience and clinical research

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NEUROIMAGE (2019)

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Promise and pitfalls of g-ratio estimation with MRI

Jennifer S. W. Campbell et al.

NEUROIMAGE (2018)

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Review Immunology

The Role of Astrocytes in Multiple Sclerosis

Gerald Ponath et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Clinical Neurology

Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging

Assunta Dal-Bianco et al.

ACTA NEUROPATHOLOGICA (2017)

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An updated histological classification system for multiple sclerosis lesions

Tanja Kuhlmann et al.

ACTA NEUROPATHOLOGICA (2017)

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Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

Bogdan F. Popescu et al.

ACTA NEUROPATHOLOGICA (2017)

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Combined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy

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BRAIN PATHOLOGY (2016)

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Feasibility and Reproducibility of Whole Brain Myelin Water Mapping in 4 Minutes Using Fast Acquisition with Spiral Trajectory and Adiabatic T2prep (FAST-T2) at 3T

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Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning

Nicholas J. Luciano et al.

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Restoring Susceptibility Induced MRI Signal Loss in Rat Brain at 9.4 T: A Step towards Whole Brain Functional Connectivity Imaging

Rupeng Li et al.

PLOS ONE (2015)

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Article Clinical Neurology

Postmortem Magnetic Resonance Imaging to Guide the Pathologic Cut: Individualized, 3-Dimensionally Printed Cutting Boxes for Fixed Brains

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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

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Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease

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FRONTIERS IN NEUROINFORMATICS (2014)

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The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions

Vaibhav A. Janve et al.

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Accuracy of the Morphology Enabled Dipole Inversion (MEDI) Algorithm for Quantitative Susceptibility Mapping in MRI

Tian Liu et al.

IEEE TRANSACTIONS ON MEDICAL IMAGING (2012)

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Quantitative Magnetic Resonance Imaging of Cortical Multiple Sclerosis Pathology

Christine L. Tardif et al.

MULTIPLE SCLEROSIS INTERNATIONAL (2012)

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Evolution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions

Maria I. Gaitan et al.

ANNALS OF NEUROLOGY (2011)

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Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords

Eric C. Klawiter et al.

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elastix: A Toolbox for Intensity-Based Medical Image Registration

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The changing demographic pattern of multiple sclerosis epidemiology

Nils Koch-Henriksen et al.

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MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

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About Axial and Radial Diffusivities

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Remyelination capacity of the MS brain decreases with disease chronicity

T. Goldschmidt et al.

NEUROLOGY (2009)

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Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation

Klaus Schmierer et al.

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Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology

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Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain

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Diffusion tensor imaging of post mortem multiple sclerosis brain

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Remyelination is extensive in a subset of multiple sclerosis patients

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Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology

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Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion

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Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain

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Evidence for pathogenic heterogeneity in multiple sclerosis

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Remyelinated lesions in multiple sclerosis -: Magnetic resonance image appearance

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High field MRI correlates of myelin content and axonal density in multiple sclerosis - A post-mortem study of the spinal cord

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Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water

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Immunopathology of secondary-progressive multiple sclerosis

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Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

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