期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 107, 期 -, 页码 385-396出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2022.11.004
关键词
Animal model; Microbiota; Gut -brain axis; Susceptibility; Resilience; Stress; P -cresol; Dopamine; PTSD
Mounting evidence suggests a link between gut microbiota abnormalities and PTSD, but the influence of gut microbiota on PTSD susceptibility is poorly understood. This study demonstrates pre-trauma and post-trauma gut microbiota alterations in susceptible mice with persistent PTSD-related phenotypes. The findings suggest that gut microbiota abnormalities contribute to trauma susceptibility and could be a potential therapeutic target for PTSD.
Mounting evidence suggests a link between gut microbiota abnormalities and post-traumatic stress disorder (PTSD). However, whether and how the gut microbiota influences PTSD susceptibility is poorly understood. Here using the arousal-based individual screening model, we provide evidence for pre-trauma and post-trauma gut microbiota alterations in susceptible mice exhibiting persistent PTSD-related phenotypes. A more in-depth analysis revealed an increased abundance of bacteria affecting brain processes including myelination, and brain systems like the dopaminergic neurotransmission. Because dopaminergic dysfunctions play a key role in the pathophysiological mechanisms subserving PTSD, we assessed whether these alterations in gut microbiota composition could be associated with abnormal levels of metabolites inducing dopaminergic dysfunctions. We found high levels of the L-tyrosine-derived metabolite p-cresol exclusively in the prefrontal cortex of susceptible mice. We further uncovered abnormal levels of dopamine and DOPAC, together with a detrimental increase of dopamine D3 receptor expression, exclusively in the prefrontal cortex of susceptible mice. Conversely, we observed either resilience mechanisms aimed at counteracting these p-cresol-induced dopaminergic dysfunctions or myelination-related resilience mechanisms only in the prefrontal cortex of resilient mice. These findings reveal that gut microbiota abnormalities foster trauma susceptibility and thus it may represent a promising target for therapeutic interventions.
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