Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Article Pediatrics

Cardiometabolic risk profile in non-obese children with obstructive sleep apnea syndrome

Anna Di Sessa et al.

Summary: Non-obese children with OSAS have a worse cardiometabolic profile, which is associated with inflammation and metabolic derangements. This study provides therapeutic strategies to improve cardiovascular health in OSAS patients.

EUROPEAN JOURNAL OF PEDIATRICS (2022)

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Review Biochemistry & Molecular Biology

Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders

Donatella Marazziti et al.

Summary: Major depressive disorder (MDD) and bipolar disorders (BDs) are the most severe types of mood disorders (MDs) and are highly disabling worldwide. Inflammatory neuroinflammation may play a role in the pathophysiology of MDs, and there is increasing evidence of its relationship with neurotransmitters, the HPA axis, and neurotrophic factors. Evaluating ratios of neutrophil/lymphocyte, platelet/lymphocyte, and monocyte/lymphocyte in peripheral blood provides a simple method for assessing inflammatory status. This review aims to explore the possible relationships between these ratios and MDs and their potential use in clinical research. The majority of included studies reported higher values of these ratios, particularly in patients with BD during a manic episode, suggesting that they may serve as both state and trait markers. Furthermore, increased NLR and PLR levels appear to predict post-stroke depression. These findings highlight the need for further research and suggest that NLR, PLR, and MLR may be promising tools for evaluating the inflammatory system and understanding the etiology and course of MDs.

CURRENT MEDICINAL CHEMISTRY (2022)

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Article Psychiatry

Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders

Yanyan Wei et al.

Summary: Our study used large-scale clinical data to investigate platelet parameters in patients with affective disorders. We found significant differences in MPV, PDW, PCT, SII, PLR, RPR, and albumin values among different groups. MPV, PDW, and albumin levels were independently correlated with MDD and BD and were important predictors for differentiating patients with MDD or BD from healthy controls. These findings highlight the role of platelet parameters and systemic inflammation in the pathophysiology of MDD and BD.

BMC PSYCHIATRY (2022)

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Article Immunology

Metabolomic and inflammatory signatures of symptom dimensions in major depression

Christopher R. Brydges et al.

Summary: "The study found that immunometabolic dysregulations are correlated with specific symptom dimensions of MDD, while different symptom dimensions have distinct metabolic signatures."

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Article Immunology

Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study

Huiqing Shi et al.

Summary: The study found that a prudent diet was associated with lower disinhibition scores partially mediated by lower inflammation, while a meat-based diet was linked to more inflammation and subsequently more disinhibition. Immune function plays a mediating role in the relationship between diet and behavioral disinhibition, but further interventional trials are needed to establish causal effects.

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Article Multidisciplinary Sciences

A preoptic neuronal population controls fever and appetite during sickness

Jessica A. Osterhout et al.

Summary: This study identifies a previously uncharacterized population of neurons in the brain that are activated after infection, playing a crucial role in generating fever response and other sickness symptoms. By examining gene expression and electrophysiological measurements, the researchers uncover a mechanism where these neurons are influenced by immune signals released by non-neuronal cells during infection and are functionally connected to brain areas controlling body temperature and appetite.

NATURE (2022)

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Article Neurosciences

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte, Platelet-to-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Different States of Bipolar Disorder

Katerina Dadouli et al.

Summary: The study found that patients with BD had higher NLR, MLR, and SII index compared to healthy controls during manic and depressive episodes, indicating a higher level of inflammation in BD patients.

BRAIN SCIENCES (2022)

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Article Neurosciences

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress

Pia Koudouovoh-Tripp et al.

Summary: Chronic mental stress is associated with increased state anxiety, depressive symptoms, and perceived stress, as well as enhanced proinflammatory platelet activity. Acute mental stress can alter platelet bioactivity and aggregation. Both chronic and acute mental stress have significant impacts on platelets, potentially linking mental and somatic disorders.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

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Article Psychiatry

Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies

Philipp Frank et al.

Summary: Evidence from various studies suggests that the effects of systemic inflammation on depression are symptom-specific rather than generalized. Future trials for anti-inflammatory treatment of depression may benefit from targeting individuals with distinct inflammation-related physical and cognitive symptoms.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Article Immunology

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability

Marco Solmi et al.

Summary: The study aimed to compare inflammatory mediators in bipolar disorder (BD) with healthy controls, finding that CRP and TNF-alpha may be state markers as they were only elevated during mood episodes, while IL-6 appeared to be a trait marker for BD. The variability of specific inflammatory mediators in specific disease active states suggests that some BD subjects may exhibit elevated inflammation during manic or depressive episodes.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Review Neurosciences

Sex differences in dopamine release regulation in the striatum

Jennifer E. Zachry et al.

Summary: The mesolimbic dopamine system plays a crucial role in sex-specific behavior and psychiatric diseases, with local regulatory mechanisms modulating dopamine release in the striatum. Sex differences in microcircuit regulatory mechanisms can alter dopamine dynamics between males and females, controlled and regulated by hormonal mechanisms. Understanding these systems and bridging the gaps in knowledge will be key in developing effective therapies targeting dopamine function in both sexes.

NEUROPSYCHOPHARMACOLOGY (2021)

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Article Neurosciences

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder

Laura Fusar-Poli et al.

Summary: This study found that inflammatory markers in blood, particularly PLR, were significantly higher in (hypo)manic patients compared to depressed patients. PLR may serve as an independent predictor of (hypo)mania, suggesting that inflammatory markers could explain the onset and recurrence of mood episodes in BD patients. Further research is needed to clarify the role of inflammatory ratios as peripheral biomarkers of BD mood episodes.

BRAIN SCIENCES (2021)

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Article Psychiatry

Elevated C-reactive protein levels across diagnoses: The first comparison among inpatients with major depressive disorder, bipolar disorder, or obsessive-compulsive disorder

Daniela Caldirola et al.

Summary: This study compared eCRP levels in patients with MDD, BD, and OCD, suggesting that eCRP may be a common feature of different psychiatric disorders. Beyond multiple confounders, other mechanisms may explain the presence of eCRP in a substantial portion of psychiatric patients.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2021)

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Article Clinical Neurology

A peripheral inflammatory signature discriminates bipolar from unipolar depression: A machine learning approach

Sara Poletti et al.

Summary: This study successfully predicted the differential diagnosis of MDD and BD by considering plasma levels of cytokines, chemokines, and growth factors, and found that the immune-inflammatory signature is key in distinguishing between the two disorders.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

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Article Psychiatry

Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count

Julia M. Sealock et al.

Summary: This genetic association study found that increased depression polygenic scores were associated with increased white blood cell count, suggesting a bidirectional association. The findings highlight the potential importance of the immune system in the etiology of depression and may lead to the development of clinical biomarkers and targeted treatment options for depression.

JAMA PSYCHIATRY (2021)

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Article Medicine, General & Internal

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

Vlad Dionisie et al.

Summary: In this study, inflammatory ratios such as NLR, MLR, PLR, and SII index were compared among patients with manic episodes of bipolar disorder, bipolar depression, and unipolar depression. The results showed that NLR was higher in manic episodes, indicating its potential as a marker for differentiating bipolar from unipolar depression.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Health Care Sciences & Services

Framework for the treatment and reporting of missing data in observational studies: The Treatment And Reporting of Missing data in Observational Studies framework

Katherine J. Lee et al.

Summary: Missing data is common in medical research, but handling them properly is crucial for the validity and reproducibility of research findings. This framework aims to help researchers address missing data systematically and transparently, thereby increasing confidence in research results.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Yuri Milaneschi et al.

Summary: The study found inflammation to be uniformly associated with core depressive symptoms of low mood and anhedonia, as well as somatic/neurovegetative symptoms of fatigue, altered sleep, and appetite changes. Inconsistent associations were observed for anxiety. The IL-6/IL-6R pathway may play a causative role in depression.

MOLECULAR PSYCHIATRY (2021)

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Article Psychiatry

The severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil-lymphocyte and platelet-lymphocyte ratios between schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and obsessive compulsive disorder

Necati Serkut Bulut et al.

Summary: The study aimed to compare the severity of inflammation between Sch, BD-M, BD-D, MDD, and OCD. Results showed that BD-M had the highest level of inflammation, followed by Sch, BD-D, and MDD, while inflammation in OCD may be lower.

NORDIC JOURNAL OF PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states

W. Kyle Simmons et al.

MOLECULAR PSYCHIATRY (2020)

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Article Neurosciences

Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression

Mary-Ellen Lynall et al.

BIOLOGICAL PSYCHIATRY (2020)

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Review Neurosciences

Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression

Yuri Milaneschi et al.

BIOLOGICAL PSYCHIATRY (2020)

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Article Psychology, Clinical

Associations between systemic inflammation and somatic depressive symptoms: Findings from the Moli-sani study

Alessandro Gialluisi et al.

DEPRESSION AND ANXIETY (2020)

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Editorial Material Neurosciences

Identifying Immunophenotypes of Inflammation in Depression: Dismantling the Monolith

Jennifer C. Felger et al.

BIOLOGICAL PSYCHIATRY (2020)

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Article Psychology, Clinical

Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships

Daniel P. Moriarity et al.

CLINICAL PSYCHOLOGICAL SCIENCE (2020)

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Review Psychology, Biological

The Effect of Selective Serotonin Reuptake Inhibitors in Healthy Subjects Revisited: A Systematic Review of the Literature

Ulla Knorr et al.

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2019)

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Review Behavioral Sciences

Revisiting inflammation in bipolar disorder

Gabriel R. Fries et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019)

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Article Immunology

Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Kimberly D. van der Willik et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Critical Care Medicine

Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy

Julia R. Coleman et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2019)

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Article Clinical Neurology

Increased Oxidative Stress, Loop Gain And The Arousal Threshold Are Clinical Predictors Of Increased Apnea Severity Following Exposure To Intermittent Hypoxia

Gino Panza et al.

NATURE AND SCIENCE OF SLEEP (2019)

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Article Clinical Neurology

Prothrombotic state in children with obstructive sleep apnea

Antonia Barcelo et al.

SLEEP MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis

S. P. Leighton et al.

MOLECULAR PSYCHIATRY (2018)

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Article Psychology, Clinical

Metabolic and inflammatory markers: associations with individual depressive symptoms

F. Lamers et al.

PSYCHOLOGICAL MEDICINE (2018)

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Article Neurosciences

Clinically relevant and simple immune system measure is related to symptom burden in bipolar disorder

Ole Kohler-Forsberg et al.

ACTA NEUROPSYCHIATRICA (2018)

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Article Cell Biology

Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia?

Dragan Djordjevic et al.

MEDIATORS OF INFLAMMATION (2018)

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Review Biochemistry & Molecular Biology

Regulation of platelet activation and thrombus formation by reactive oxygen species

Jianlin Qiao et al.

REDOX BIOLOGY (2018)

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Review Psychiatry

Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses

Tobias Rowland et al.

BRITISH JOURNAL OF PSYCHIATRY (2018)

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Review Behavioral Sciences

The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation

Larissa N. Dooley et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

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Review Clinical Neurology

Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular Complications via Blood Platelets

Agata Gabryelska et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Genetics & Heredity

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Symen Ligthart et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2018)

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Article Psychology, Mathematical

Estimating psychological networks and their accuracy: A tutorial paper

Sacha Epskamp et al.

BEHAVIOR RESEARCH METHODS (2018)

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Review Psychiatry

A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients - a retrospective file review

Selcuk Ozdin et al.

NORDIC JOURNAL OF PSYCHIATRY (2017)

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Article Psychology

Risk Factors for Suicidal Thoughts and Behaviors: A Meta-Analysis of 50 Years of Research

Joseph C. Franklin et al.

PSYCHOLOGICAL BULLETIN (2017)

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Article Endocrinology & Metabolism

Depression and anxiety symptoms are associated with white blood cell count and red cell distribution width: A sex-stratified analysis in a population based study

Mojtaba Shafiee et al.

PSYCHONEUROENDOCRINOLOGY (2017)

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Editorial Material Respiratory System

Connecting insomnia, sleep apnoea and depression

Michael A. Grandner et al.

RESPIROLOGY (2017)

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Review Neurosciences

Bipolar Disorder and Immune Dysfunction: Epidemiological Findings, Proposed Pathophysiology and Clinical Implications

Joshua D. Rosenblat et al.

BRAIN SCIENCES (2017)

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Article Psychology, Multidisciplinary

Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health's Research Domain Criteria (RDoC)

Lee Anna Clark et al.

PSYCHOLOGICAL SCIENCE IN THE PUBLIC INTEREST (2017)

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Article Fisheries

Neuroendocrine-immune interaction: Evolutionarily conserved mechanisms that maintain allostasis in an ever-changing environment

B. M. Lidy Verburg-van Kemenade et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2017)

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Article Biochemistry & Molecular Biology

Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α

D. Baumeister et al.

MOLECULAR PSYCHIATRY (2016)

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Article Biochemistry & Molecular Biology

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

D. R. Goldsmith et al.

MOLECULAR PSYCHIATRY (2016)

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Article Psychiatry

Platelet parameters (PLT, MPV, P-LCR) in patients with schizophrenia, unipolar depression and bipolar disorder

Adam Wysokinski et al.

PSYCHIATRY RESEARCH (2016)

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Review Immunology

The role of inflammation in depression: from evolutionary imperative to modern treatment target

Andrew H. Miller et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Neurosciences

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People

Georg S. Kranz et al.

BIOLOGICAL PSYCHIATRY (2015)

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Article Clinical Neurology

Sleep Patterns in Adults with a Diagnosis of High-Functioning Autism Spectrum Disorder

Emma K. Baker et al.

SLEEP (2015)

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Article Genetics & Heredity

Platelet studies in autism spectrum disorder patients and first-degree relatives

Nora Bijl et al.

MOLECULAR AUTISM (2015)

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Review Immunology

Are platelets cells? And if yes, are they immune cells?

Olivier Garraud et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Clinical Neurology

Sleep Patterns in Adults with a Diagnosis of High-Functioning Autism Spectrum Disorder

Emma K. Baker et al.

SLEEP (2015)

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Review Physiology

The role of serotonin and its receptors in activation of immune responses and inflammation

M. S. Shajib et al.

ACTA PHYSIOLOGICA (2015)

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Article Psychology, Multidisciplinary

Integrating NIMH Research Domain Criteria (RDoC) into depression research

Mary L. Woody et al.

CURRENT OPINION IN PSYCHOLOGY (2015)

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Article Hematology

Paraneoplastic thrombocytosis: the secrets of tumor self-promotion

Richard J. Lin et al.

BLOOD (2014)

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Article Biochemistry & Molecular Biology

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression

F. Lamers et al.

MOLECULAR PSYCHIATRY (2013)

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Article Engineering, Electrical & Electronic

A comparative analysis of Spearman's rho and Kendall's tau in normal and contaminated normal models

Weichao Xu et al.

SIGNAL PROCESSING (2013)

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Article Psychiatry

The Link Between Suicide and Insomnia: Theoretical Mechanisms

W. Vaughn McCall et al.

CURRENT PSYCHIATRY REPORTS (2013)

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Article Clinical Neurology

A French network of bipolar expert centres: A model to close the gap between evidence-based medicine and routine practice

Chantal Henry et al.

JOURNAL OF AFFECTIVE DISORDERS (2011)

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Review Biochemistry & Molecular Biology

MOLECULAR MECHANISMS OF SERT IN PLATELETS: Regulation of Plasma Serotonin Levels

Charles P. Mercado et al.

MOLECULAR INTERVENTIONS (2010)

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Article Clinical Neurology

Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?

Lucile Capuron et al.

JOURNAL OF AFFECTIVE DISORDERS (2009)

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Article Mathematical & Computational Biology

Sparse inverse covariance estimation with the graphical lasso

Jerome Friedman et al.

BIOSTATISTICS (2008)

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Article Cell Biology

The effect of exercise and training status on platelet activation: Do cocoa polyphenols play a role?

I. Singh et al.

PLATELETS (2006)

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Article Neurosciences

The 16-item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): A psychometric evaluation in patients with chronic major depression

AJ Rush et al.

BIOLOGICAL PSYCHIATRY (2003)

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Review Immunology

The relationship of depression and stressors to immunological assays: A meta-analytic review

EP Zorrilla et al.

BRAIN BEHAVIOR AND IMMUNITY (2001)

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Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

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