4.7 Review

Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases

期刊

BRAIN
卷 146, 期 6, 页码 2227-2240

出版社

OXFORD UNIV PRESS
DOI: 10.1093/brain/awad014

关键词

neurodegeneration; neuroinflammation; ROS; autophagy; gold quantum clusters

向作者/读者索取更多资源

Developing drugs that can cross the blood-brain barrier is a challenge for treating neurodegenerative disease. The use of nanoparticle-based systems shows potential in overcoming this difficulty, with the example of Friedreich's ataxia. Neurodegenerative diseases are a global health burden, and traditional interventions have limitations in reaching the brain. Nanosystems offer a promising therapeutic approach by delivering drugs and improving bioavailability. This review highlights the use of nanosystems in targeting molecular pathways involved in neurodegenerative diseases, with Friedreich's ataxia as an example.
Developing drugs that can cross the blood-brain barrier is a major challenge for the treatment of neurodegenerative disease. Mistretta et al. discuss the potential of nanoparticle-based systems to overcome this difficulty and review their use in Friedreich's ataxia as a test case. Neurodegenerative diseases are a major global health burden particularly with the increasing ageing population. Hereditary predisposition and environmental risk factors contribute to the heterogeneity of existing pathological phenotypes. Traditional clinical interventions focused on the use of small drugs have often led to failures due to the difficulties in crossing the blood-brain barrier and reaching the brain. In this regard, nanosystems can specifically deliver drugs and improve their bioavailability, overcoming some of the major challenges in neurodegenerative disease treatment. This review focuses on the use of nanosystems as an encouraging therapeutic approach targeting molecular pathways involved in localized and systematic neurodegenerative diseases. Among the latter, Friedreich's ataxia is an untreatable complex multisystemic disorder and the most widespread type of ataxia; it represents a test case to validate the clinical potential of therapeutic strategies based on nanoparticles with pleiotropic effects.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据