期刊
BMC HEALTH SERVICES RESEARCH
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12913-022-08683-y
关键词
Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Budget impact
资金
- Celltrion Healthcare Co., Ltd.
This article presents a budget impact analysis on the introduction of infliximab SC to European markets. The results show that the use of infliximab SC for the treatment of inflammatory bowel disease can lead to budget savings in the UK, Germany, France, and Italy.
Background In 2020, the European Medicines Agency approved infliximab subcutaneous (SC) for the treatment of inflammatory bowel disease. This new mode of infliximab administration will reduce outpatient visits and costs of intravenous (IV) administration. This article describes a budget impact analysis of introducing infliximab SC to the Big-5 European (E5) market (Germany, France, Italy, Spain and UK) for 5 years, from the healthcare payer's perspective. Methods A prevalence-based budget impact model was developed to examine the financial impact of infliximab SC. World with versus world without infliximab SC scenarios were compared, including the potential administration costs of IV administration. Results Introducing infliximab SC in patients with Crohn's disease (CD) for 5 years resulted in cost savings of euro42.0 million in the UK, euro59.4 million in Germany, and euro46.4 million in France and Italy, but increased budget expenditure in Spain by euro3.8 million. For ulcerative colitis (UC), cost savings of euro42.7 million in the UK, euro44.9 million in Germany, euro44.3 million in France, and euro53.0 million in Italy occurred, but with no savings in Spain for 5 years. Cost-savings per patient was calculated by diving the net budget saving by number of treatment eligible patients. Maximum and minimum saving per patient per year ranged between euro38.25 and euro575.74 in CD, both from Germany, and euro105.06 (France) and euro647.25 (Germany) in UC. Conclusion Healthcare payers in the UK, Germany, France, and Italy, but not in Spain, will make budget savings by using infliximab SC for the treatment of inflammatory bowel disease.
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