4.6 Article

Prognostic and clinical significance of HER-2 low expression in early-stage gastric cancer

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BMC CANCER
卷 22, 期 1, 页码 -

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BMC
DOI: 10.1186/s12885-022-10262-7

关键词

Gastric cancer; HER-2; Prognosis; Clinical characteristics

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资金

  1. National Nature Science Foundation of China [82003006, 82102878]
  2. Nature Science Foundation of Hainan Province [821QN384]

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Gastric cancer is the fifth most common tumor worldwide. HER2-low expression in early-stage gastric cancer was associated with certain clinical characteristics, but did not have prognostic value for disease-free survival or overall survival.
Introduction Gastric cancer is the most fifth common tumor worldwide. Human epidermal growth factor receptor 2 (HER2) overexpression is associated with poor prognosis and clinical characteristics in gastric cancer. Nevertheless, the biology of HER2-low expression has not reported in gastric cancer. Materials and methods A total of 157 patients with early-stage gastric cancer were retrospectively analyzed. The associations between HER-2 low expression and clinical characteristics were analyzed by Chi-square test. And the prognostic value of HER-2 low expression and clinical characteristics in disease-free survival (DFS) and overall survival (OS) were analyzed by univariate and multivariate Cox regression analysis. Results Of 157 patients with early-stage gastric cancer, 31.8% had HER2-low tumors and 50.3% had HER2-negative tumors. HER2-low expression was associated with age, histological differentiation, tumor location and Ki-67 index. However, HER2-low expression was not associated with DFS or OS in early-stage gastric cancer. Conclusion HER2-low expression might result in distinct biology, but it was not an independent prognostic factor of DFS or OS in early-stage gastric cancer.

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