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The cholinergic system in aging and neuronal degeneration
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Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma
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Alzheimer-type neuropathological changes in morbidly obese elderly individuals
R.E. Mrak
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Elevated Plasma Homocysteine Is Associated with Increased Brain Atrophy Rates in Older Subjects with Mild Hypertension
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Do men develop type 2 diabetes at lower body mass indices than women?
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Vascular and metabolic dysfunction in Alzheimer's disease: a review
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Distinct spatiotemporal patterns of spreading depolarizations during early infarct evolution: evidence from real-time imaging
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Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury
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Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic
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Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
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A longitudinal study of gray matter volume decline with age and modifying factors
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Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study
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Consistent neuroanatomical age-related volume differences across multiple samples
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被撤回的出版物: Clazosentan, a novel endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury (Retracted article. See vol. 39, pg. 472, 2017)
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Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
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NEUROSCIENCE LETTERS (2011)
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
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Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease
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Relationship of Serum and Cerebrospinal Fluid Biomarkers With Intracranial Hypertension and Cerebral Hypoperfusion After Severe Traumatic Brain Injury
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Aldose Reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats
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The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate
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The vascular contribution to Alzheimer's disease
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Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension
Michael J. Firbank et al.
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Early Stages of Pathogenesis in Memory Impairment during Normal Senescence and Alzheimer's Disease
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Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study
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Neuron-Selective Toxicity of Tau Peptide in a Cell Culture Model of Neurodegenerative Tauopathy: Essential Role for Aggregation in Neurotoxicity
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How Mild Traumatic Brain Injury May Affect Declarative Memory Performance in the Post-Acute Stage
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Inflammatory Markers and Incident Heart Failure Risk in Older Adults The Health ABC (Health, Aging, and Body Composition) Study
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Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
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Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease
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Obesity is linked with lower brain volume in 700 AD and MCI patients
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Vascular basis for brain degeneration: faltering controls and risk factors for dementia
Raj N. Kalaria
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BMI and Neuronal Integrity in Healthy, Cognitively Normal Elderly: A Proton Magnetic Resonance Spectroscopy Study
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THORAX (2010)
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Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease
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Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
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ACTA NEUROPATHOLOGICA (2009)
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ACTA NEUROPATHOLOGICA (2009)
Blood pressure and the risk for dementia-A double edged sword
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Mechanisms of Neurodegeneration and Regeneration in Alcoholism
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ALCOHOL AND ALCOHOLISM (2009)
The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
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Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms
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The Role of Vascular Factors in Late-Onset Sporadic Alzheimer's Disease. Genetic and Molecular Aspects
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Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy
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Obesity Increases Blood Pressure, Cerebral Vascular Remodeling, and Severity of Stroke in the Zucker Rat
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Decreased cortical glucose metabolism in converters from CDR 0.5 to Alzheimer's disease in a community: the Osaki-Tajiri Project
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Control of mitochondrial apoptosis by the Bcl-2 family
Joslyn K. Brunelle et al.
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Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex
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Subcortical Vascular versus Amnestic Mild Cognitive Impairment: Comparison of Cerebral Glucose Metabolism
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ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
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Basal Cerebral Metabolism May Modulate the Cognitive Effects of Aβ in Mild Cognitive Impairment: An Example of Brain Reserve
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Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans
Glen E. Foster et al.
JOURNAL OF PHYSIOLOGY-LONDON (2009)
ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
Kohsuke Kanekura et al.
MOLECULAR NEUROBIOLOGY (2009)
APOE-related mortality: Effect of dementia, cardiovascular disease and gender
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Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances
Dietmar Rudolf Thal et al.
NEUROBIOLOGY OF AGING (2009)
Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area
Bradford C. Dickerson et al.
NEUROBIOLOGY OF AGING (2009)
Factors associated with resistance to dementia despite high Alzheimer disease pathology
D. Erten-Lyons et al.
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Age, Alzheimer disease, and brain structure
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NEUROLOGY (2009)
EDARAVONE ATTENUATES WHITE MATTER LESIONS THROUGH ENDOTHELIAL PROTECTION IN A RAT CHRONIC HYPOPERFUSION MODEL
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CRUCIAL ROLE FOR Ser133-PHOSPHORYLATED FORM OF CYCLIC AMP-RESPONSIVE ELEMENT BINDING PROTEIN SIGNALING IN THE DIFFERENTIATION AND SURVIVAL OF NEURAL PROGENITORS UNDER CHRONIC CEREBRAL HYPOPERFUSION
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NEUROSCIENCE (2009)
Cerebral vasoreactivity decreases overnight in severe obstructive sleep apnea syndrome: A study of cerebral hemodynamics
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SLEEP MEDICINE (2009)
Inflammation and White Matter Damage in Vascular Cognitive Impairment
Gary A. Rosenberg
STROKE (2009)
Gender Differences in Stroke Incidence and Poststroke Disability in the Framingham Heart Study
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STROKE (2009)
Spreading depolarizations occur in human ischemic stroke with high incidence
Christian Dohmen et al.
ANNALS OF NEUROLOGY (2008)
Hypertension, cognitive decline and dementia
E. Duron et al.
ARCHIVES OF CARDIOVASCULAR DISEASES (2008)
Combining Early Markers Strongly Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease
Davangere P. Devanand et al.
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IIC PiB and structural MRI provide complementary information in imaging of Alzheimers disease and amnestic mild cognitive impairment
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Protective effects of cilostazol against transient focal cerebral ischemia and chronic cerebral hypoperfusion injury
Jeong Hyun Lee et al.
CNS NEUROSCIENCE & THERAPEUTICS (2008)
The stress rheostat:: An interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration
Soledad Matus et al.
CURRENT MOLECULAR MEDICINE (2008)
Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis
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DIABETES (2008)
Individual cerebral metabolic deficits in Alzheimer's disease and amnestic mild cognitive impairment: an FDG PET study
Angelo Del Sole et al.
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Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats
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Mechanism of alcohol-induced oxidative stress and neuronal injury
James Haorah et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new therapeutic potential
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FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Coupling between neuronal activity and microcirculation: implications for functional brain imaging
Ivo Vanzetta et al.
HFSP JOURNAL (2008)
Impaired cerebral autoregulation in obstructive sleep apnea
Fred Urbano et al.
JOURNAL OF APPLIED PHYSIOLOGY (2008)
Neuronal hypertrophy in asymptomatic Alzheimer disease
Diego Iacono et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats Laboratory Investigation
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
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Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign - Commentary on no disease in the brain of a 115-year-old woman
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Hippocampal hypornetabolism predicts cognitive decline from normal aging
Lisa Mosconi et al.
NEUROBIOLOGY OF AGING (2008)
Detection of structural changes of the human brain in longitudinally acquired MR images by deformation field morphometry: Methodological analysis, validation and application
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B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice
Aron M. Troen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion
Zhi-You Cai et al.
Neuroscience Bulletin (2008)
Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse
James Haorah et al.
GLIA (2008)
Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons
Miguel Angel Riudavets et al.
NEUROBIOLOGY OF AGING (2007)
Contribution of metabolic syndrome components to cognition in older individuals
Miranda G. Dik et al.
DIABETES CARE (2007)
Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease
Aoife Hunt et al.
PSYCHIATRY RESEARCH-NEUROIMAGING (2007)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Gender differences in dementia risk factors
Nahid A. Azad et al.
GENDER MEDICINE (2007)
Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure
Michael J. Firbank et al.
JOURNAL OF NEUROLOGY (2007)
Blood-brain barrier impairment in Alzheimer disease - Stability and functional significance
G. L. Bowman et al.
NEUROLOGY (2007)
Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity
David Last et al.
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Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
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Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
Rashid Deane et al.
CURRENT ALZHEIMER RESEARCH (2007)
Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction
James Haorah et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Effects of continuous positive airway pressure on cerebral vascular response to hypoxia in patients with obstructive sleep apnea
Glen E. Foster et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
Anthony J. Strong et al.
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Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities
V. Hester ten Dam et al.
RADIOLOGY (2007)
Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
E. Koevari et al.
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Edaravone reduces ischemia-reperfusion injury mediators in rat liver
Masanobu Taniguchi et al.
JOURNAL OF SURGICAL RESEARCH (2007)
Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusion-related neurodegenerative diseases
Eszter Farkas et al.
BRAIN RESEARCH REVIEWS (2007)
Positron emission tomography imaging in dementia
K. Herholz et al.
BRITISH JOURNAL OF RADIOLOGY (2007)
Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
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ACTA NEUROPATHOLOGICA (2007)
The enigma of vascular cognitive disorder and vascular dementia
Kurt A. Jellinger
ACTA NEUROPATHOLOGICA (2007)
Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP
Klaus Ernst Ludwig Scheckenbach et al.
EXPERIMENTAL NEUROLOGY (2006)
Increased risk of death in community-dwelling older people with white matter hyperintensities on MRI
Kevin A. Kerber et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
Henry Engler et al.
BRAIN (2006)
The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison
Brian Jeynes et al.
ACTA NEUROPATHOLOGICA (2006)
Blood-brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
Yuri Persidsky et al.
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Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with Borna disease virus
B. L. Williams et al.
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Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
Hwa Kyoung Shin et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)
Brain abnormalities in human obesity: A voxel-based morphometric study
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NEUROIMAGE (2006)
Dysmorphology and microstruotural degradation of the corpus callosum: Interaction of age and alcoholism
Adolf Pfefferbaum et al.
NEUROBIOLOGY OF AGING (2006)
Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
Vera Novak et al.
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Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion
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STROKE (2006)
ER stress and neurodegenerative diseases
D Lindholm et al.
CELL DEATH AND DIFFERENTIATION (2006)
Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex
M Fabricius et al.
BRAIN (2006)
Stereologic analysis of microvascular morphology in the elderly:: Alzheimer disease pathology and cognitive status
Constantin Bouras et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Cilostazol: Therapeutic potential against focal cerebral ischemic damage
KW Hong et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Low doses of alcohol substantially decrease glucose metabolism in the human brain
ND Volkow et al.
NEUROIMAGE (2006)
Update on hypertension and Alzheimer's disease
Ingmar Skoog et al.
NEUROLOGICAL RESEARCH (2006)
The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
Agnes Goerlach et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
MA Ward et al.
BMC NEUROLOGY (2005)
Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease - therapeutic potential
W Paschen et al.
PHARMACOLOGY & THERAPEUTICS (2005)
Association of sleep-disordered breathing and the occurrence of stroke
M Arzt et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)
Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction
J Haorah et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2005)
Global prevalence of dementia: a Delphi consensus study
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LANCET (2005)
Obstructive sleep apnea as a risk factor for stroke and death
HK Yaggi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
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STROKE (2005)
Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms
J Attems
ACTA NEUROPATHOLOGICA (2005)
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
M Kivipelto et al.
ARCHIVES OF NEUROLOGY (2005)
An emotional mediation theory of differential age effects in episodic and semantic memories
PA Allen et al.
EXPERIMENTAL AGING RESEARCH (2005)
Relationship between regional cerebral blood flow and separate symptom clusters of major depression:: A single photon emission computed tomography study using statistical parametric mapping
CAM Périco et al.
NEUROSCIENCE LETTERS (2005)
Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle:: Role of Gs α and cAMP
Q Wan et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2005)
Age-related alterations in white matter microstructure measured by diffusion tensor imaging
DH Salat et al.
NEUROBIOLOGY OF AGING (2005)
The age-dependent relation of blood pressure to cognitive function and dementia
CX Qiu et al.
LANCET NEUROLOGY (2005)
Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise
J Haorah et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2005)
The blood-brain barrier/neurovascular unit in health and disease
BT Hawkins et al.
PHARMACOLOGICAL REVIEWS (2005)
Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia
G Gold et al.
STROKE (2005)
Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
AF Fotenos et al.
NEUROLOGY (2005)
Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
JD Fryer et al.
JOURNAL OF NEUROSCIENCE (2005)
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
DA Bennett et al.
NEUROLOGY (2005)
Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events
MC Parkin et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2005)
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: Initial experience
NA Johnson et al.
RADIOLOGY (2005)
Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels
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NEUROSCIENCE (2005)
Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney
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KIDNEY INTERNATIONAL (2004)
Age-associated changes in the metabolism of vitamin B12 and folic acid:: Prevalence, etiopathogenesis and pathophysiological consequences
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ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (2004)
Cortical microinfarcts and demyelination significantly affect cognition in brain aging
E Kövari et al.
STROKE (2004)
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
EM Reiman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cerebral ischemia and the unfolded protein response
DJ DeGracia et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Sleep-disordered breathing, glucose intolerance, and insulin resistance - The Sleep Heart Health Study
NM Punjabi et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2004)
Homocysteine and the brain in midadult life - Evidence for an increased risk of leukoaraiosis in men
P Sachdev et al.
ARCHIVES OF NEUROLOGY (2004)
Thinning of the cerebral cortex in aging
DH Salat et al.
CEREBRAL CORTEX (2004)
A 24-year follow-up of body mass index and cerebral atrophy
D Gustafson et al.
NEUROLOGY (2004)
The metabolic syndrome, inflammation, and risk of cognitive decline
K Yaffe et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
I Ferrer et al.
BRAIN PATHOLOGY (2004)
Pronounced hypoperfusion during spreading depression in mouse cortex
C Ayata et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)
Hypertension, hypertension-clustering factors and Alzheimer's disease
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NEUROLOGICAL RESEARCH (2003)
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