Switching from salvage chemotherapy to immunotherapy in adult B-cell acute lymphoblastic leukemia

About one-half of adults with acute B-cell lymphoblastic leukemia (B-ALL) who do not achieve molecular complete remission or who subsequently relapse are not cured by current chemo- or targeted therapies. Previously, the sole therapeutic option for such persons was a hematopoietic stem cell transplant. Recently, several immune therapies including monoclonal antibodies, bispecific T-cell engagers (BiTEs), antibody-drug conjugates (ADCs), and chimeric antigen receptor T-cells (CARs) have been shown safe and effective in this setting. In this manuscript, we summarize data on US FDA-approved immune therapies of advanced adult B-ALL including rituximab, blinatumomab, inotuzumab ozogamicin, tisagenlecleucel and brexucabtagene autoleucel. We consider the results of clinical trials focusing on efficacy, safety, and quality of life (QoL). Real-world evidence is presented as well. We also briefly discuss pharmacodynamics, pharmacokinetics, and pharmacoeconomics followed by risk-benefit analyses. Lastly, we present future directions of immune therapies for advanced B-ALL in adults.

Automated summary

About half of adults with acute B-cell lymphoblastic leukemia (B-ALL) who do not achieve complete remission or relapse are not cured by current therapies. Immune therapies, including monoclonal antibodies, BiTEs, ADCs, and CARs, have shown effectiveness in this setting. This manuscript summarizes FDA-approved immune therapies for advanced adult B-ALL, their efficacy, safety, QoL, and future directions.