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Transferrin receptor 1: Keeper of HFE

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Article Hematology

Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia

Xia Xiao et al.

Summary: This study investigated the role of transferrin receptor 1 (TfR1) in cellular iron uptake and its interaction with the HFE protein to regulate hepcidin production. The results showed that hepatocyte TfR1 function depends on HFE and contributes to hepcidin suppression and iron overload in beta-thalassemia. The study also demonstrated the modulatory effect of serum iron on hepcidin regulation by hepatocyte TfR1.
Article Hematology

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

Paul J. Schmidt et al.

AMERICAN JOURNAL OF HEMATOLOGY (2012)

Article Cell Biology

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

Paul J. Schmidt et al.

CELL METABOLISM (2008)

Article Biochemistry & Molecular Biology

The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells

Junwei Gao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Gastroenterology & Hepatology

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload

Daniel F. Wallace et al.

GASTROENTEROLOGY (2007)