4.8 Article

Construction of a high-throughput aorta smooth muscle-on-a-chip for thoracic aortic aneurysm drug screening

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction

Rui Song et al.

Summary: MicroRNA-210 protects the heart from myocardial ischemia-reperfusion injury by controlling mitochondrial bioenergetics and ROS flux. Deficiency of microRNA-210 exacerbates cardiac dysfunction, while glycerol-3-phosphate dehydrogenase plays a key role in this process.

CIRCULATION (2022)

Article Biotechnology & Applied Microbiology

Long non-coding RNA HIF1A-AS2 modulates the proliferation, migration, and phenotypic switch of aortic smooth muscle cells in aortic dissection via sponging microRNA-33b

Kai Zhang et al.

Summary: This study investigated the functional role of lncRNA HIF1A-AS2 in aortic dissection (AD). Results showed that inhibiting HIF1A-AS2 suppressed the proliferation and migration of smooth muscle cells (SMCs) and promoted phenotypic switching. Additionally, the study identified a correlation between HIF1A-AS2, miR-33b, and HMGA2.

BIOENGINEERED (2022)

Article Medicine, General & Internal

Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm

Wenrui Ma et al.

Summary: This study developed a dynamic three-dimensional microphysiological model for studying thoracic aortic aneurysm (TAA) and drug discovery. The model successfully recapitulated the expressions of TAA-related genes and highlighted the disease characteristics of TAA. Drug testing demonstrated that metformin partially restored the function of TAA patients' cells. Mouse experiments and clinical investigations also supported the effectiveness of metformin in limiting aortic dilation.

EBIOMEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways

Neekun Sharma et al.

Summary: In this study, it was found that IL12p40 deficiency induced fibro-proteolytic activities in the aneurysmal mouse model, mediated by the crosstalk of CCN2/matrix metalloproteinase-2 in the medial layer of aneurysmal aortae.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

Jorge Oller et al.

Summary: Mitochondrial dysfunction is a hallmark of aortic aneurysm disease in Marfan syndrome, and boosting mitochondrial function through enhancing Tfam levels shows promise as a potential therapeutic strategy for managing aortic aneurysms.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes

Sabrina Geisberger et al.

Summary: Research shows that high salt intake leads to intracellular sodium accumulation, inhibiting mitochondrial respiration in macrophages and affecting immune cell function. While these changes may help resolve bacterial infections, they could also accelerate the development of inflammatory cardiovascular diseases.

CIRCULATION (2021)

Article Biochemical Research Methods

A well plate-based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

Benjamin Fook Lun Lai et al.

Summary: The study presents an alternative method for cultivating millimeter-scale functional vascularized tissues on a biofabricated platform, facilitating the easy integration of organoid technology. By utilizing 3D stamping with a synthetic polymeric elastomer, a scaffold called 'AngioTube' is generated to support a perfusable vascular system and the self-assembly of various parenchymal tissues. The platform allows easy connection of two or more tissue compartments through a common vasculature, with built-in micropores for studying cell invasion.

NATURE PROTOCOLS (2021)

Article Cardiac & Cardiovascular Systems

A Novel Mechanism Underlying Inflammatory Smooth Muscle Phenotype in Abdominal Aortic Aneurysm

Dunpeng Cai et al.

Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.

CIRCULATION RESEARCH (2021)

Article Biology

Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Mieradilijiang Abudupataer et al.

Summary: Bicuspid aortic valve (BAV) is a common congenital cardiovascular disease associated with thoracic aortic aneurysm (TAA). Insufficiency of NOTCH1 expression is related to BAV-TAA, with impaired mitochondrial dynamics observed. Knockdown of NOTCH1 in HAoSMCs resulted in reduced contractile phenotype and attenuated mitochondrial fusion, which could be partially rescued by mitochondrial fusion activators or fission inhibitor. This study suggests impaired mitochondrial dynamics as a potential therapeutic target for BAV-TAA.
Article Multidisciplinary Sciences

Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip

Peng Zhao et al.

Summary: In this study, it was found that low and oscillatory shear stress can induce pro-inflammatory endothelial-to-mesenchymal transition, leading to smooth muscle cell proliferation and extracellular matrix protein up-regulation. IL-37 was shown to suppress this pro-inflammatory transformation, thereby preventing abnormal smooth muscle cell proliferation and ECM protein remodeling.

SCIENCE ADVANCES (2021)

Article Cardiac & Cardiovascular Systems

Cellular Mechanisms of Aortic Aneurysm Formation

Raymundo Alain Quintana et al.

CIRCULATION RESEARCH (2019)

Article Nanoscience & Nanotechnology

Surface Modification of Glass/PDMS Microfluidic Valve Assemblies Enhances Valve Electrical Resistance

Xuemin Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Surgery

Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease

Wei Wang et al.

JOURNAL OF VASCULAR SURGERY (2018)

Editorial Material Hematology

Smooth Muscle Cells Move With Mitochondria

Ning Shi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

H19 Induces Abdominal Aortic Aneurysm Development and Progression

Daniel Y. Li et al.

CIRCULATION (2018)

Article Biochemical Research Methods

3D-printed Quake-style microvalves and micropumps

Yuan-Sheng Lee et al.

LAB ON A CHIP (2018)

Article Biochemical Research Methods

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Duc T. T. Phan et al.

LAB ON A CHIP (2017)

Review Biochemistry & Molecular Biology

Mitochondrial composition and function under the control of hypoxia

Dominik C. Fuhrmann et al.

REDOX BIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Decreased Aortic Elasticity in Children With Marfan Syndrome or Loeys-Dietz Syndrome

Yohei Akazawa et al.

CIRCULATION JOURNAL (2016)

Article Hematology

Divergent Roles of Matrix Metalloproteinase 2 in Pathogenesis of Thoracic Aortic Aneurysm

Mengcheng Shen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Review Cardiac & Cardiovascular Systems

Thoracic Aortic Aneurysm and Dissection

Judith Z. Goldfinger et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Medicine, General & Internal

Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

R. V. Lacro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Cardiac & Cardiovascular Systems

Longitudinal and Circumferential Strain of the Proximal Aorta

Vanessa Bell et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

Article Cardiac & Cardiovascular Systems

Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

Maarten Groenink et al.

EUROPEAN HEART JOURNAL (2013)

Review Biochemistry & Molecular Biology

Mitochondria: In Sickness and in Health

Jodi Nunnari et al.

Article Cardiac & Cardiovascular Systems

Local mechanical and structural properties of healthy and diseased human ascending aorta tissue

Nusrat Choudhury et al.

CARDIOVASCULAR PATHOLOGY (2009)

Article Multidisciplinary Sciences

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Huafeng Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Cardiac & Cardiovascular Systems

Effect of beta-blockade on ascending aortic dilatation in children with the Marfan syndrome

Magalie Ladouceur et al.

AMERICAN JOURNAL OF CARDIOLOGY (2007)