期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 19, 页码 5252-5263出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4599-15.2016
关键词
axon-targeting; cortex; dLGN; retina; target selection; visual system
资金
- National Institutes of Health [R01EY022117]
- [FA1-00617-1]
Retinal ganglion cells (RGCs) relay information about the outside world to multiple subcortical targets within the brain. This information is either used to dictate reflexive behaviors or relayed to the visual cortex for further processing. Many subcortical visual nuclei also receive descending inputs from projection neurons in the visual cortex. Most areas receive inputs from layer 5 cortical neurons in the visual cortex but one exception is the dorsal lateral geniculate nucleus (dLGN), which receives layer 6 inputs and is also the only RGC target that sends direct projections to the cortex. Here we ask how visual system development and function changes in mice that develop without a cortex. We find that the development of a cortex is essential for RGC axons to terminate in the dLGN, but is not required for targeting RGC axons to other subcortical nuclei. RGC axons also fail to target to the dLGN in mice that specifically lack cortical layer 6 projections to the dLGN. Finally, we show that when mice develop without a cortex they can still perform a number of vision-dependent tasks.
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