Pharmacological effects of salidroside on central nervous system diseases

Article Biochemistry & Molecular Biology

Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN

Rui Ji et al.

Summary: The study demonstrates the inhibitory effect of salidroside on DHT-induced oxidative stress and apoptosis in KGN cells, which is dependent on the activation of the Nrf2 signaling pathway involving AMPK.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)

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Article Allergy

Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3β Signaling Pathway

Xue Luan et al.

Summary: This study demonstrated that SAL can inhibit bronchial hyperresponsiveness and reduce airway inflammation by increasing AMPK phosphorylation and inhibiting Akt and GSK3 beta signaling pathways. The results showed that SAL significantly decreased levels of airway inflammatory factors in asthmatic mice and reduced airway inflammation infiltration and goblet cell proliferation.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma

Lesley Jia Wei Pua et al.

Summary: JNK and p38 MAPK signaling pathways play important roles in nasopharyngeal carcinoma (NPC), promoting tumor processes such as cell proliferation, apoptosis, inflammation, metastasis, and angiogenesis. Although the underlying mechanisms are not fully understood, further research on JNK and p38 MAPK could provide important insights for diagnosis, prognosis, and treatment decision-making in NPC patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins

Qi Zeng et al.

Summary: Salidroside (Sal) enhances the inhibitory activity of doxorubicin (DOX) in drug-resistant cancer cell lines by regulating the expression of multiple proteins. This study suggests that Sal could be a novel chemosensitization agent for the treatment of multi-drug-resistance tumors.

JOURNAL OF NATURAL PRODUCTS (2022)

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Article Cell Biology

Salidroside suppresses the activation of nasopharyngeal carcinoma cells via targeting miR-4262/GRP78 axis

Shaosheng Liu et al.

Summary: The study found that Salidroside can significantly inhibit the proliferation and promote apoptosis of nasopharyngeal carcinoma (NPC) cells by regulating the miR-4262/GRP78 signaling axis.

CELL CYCLE (2022)

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Article Pharmacology & Pharmacy

Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-?B/NLRP3 pathway

Shengnan Jiang et al.

Summary: Salidroside from Rhodiola crenulate can attenuate cerebral injury caused by hypobaric hypoxia at high altitude by reducing oxidative stress and inflammation, improving energy metabolism, and modulating the microglial phenotype. These mechanisms inhibit NF-kappa B/NLRP3 pathway and protect the blood-brain barrier, suggesting Sal as a promising anti-inflammatory agent for high altitude-induced brain injury.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Cell Biology

Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis

Xing-Mei Shu et al.

Summary: In this study, the neuroprotective effects of salidroside (SAL) against Cd-induced toxicity were investigated. SAL attenuated Cd toxicity in cultured cells and protected mice from organic damage and cognitive deficits. It alleviated oxidative stress, glial cell activation, and pro-inflammatory factors elevation induced by Cd. Moreover, SAL maintained antioxidant enzyme activity and restored redox homeostasis, attenuating neuronal damage. It also inhibited Cd-induced inflammatory signaling pathway activation and neuronal loss. The findings suggest that SAL has potential anti-Cd effects and Rhodiola rosea is a promising plant for cultivation.

INFLAMMATION RESEARCH (2022)

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Review Urology & Nephrology

Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease

Miao Wang et al.

Summary: Hyperuricemia is an independent risk factor for the progression of chronic kidney disease. There is a close relationship between uric acid and the NLRP3 inflammasome. Activation of the NLRP3 inflammasome can cause cell damage and trigger inflammatory responses through different molecular mechanisms.

RENAL FAILURE (2022)

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Article Pharmacology & Pharmacy

Development of Jelly Loaded with Nanogel Containing Natural L-Dopa from Mucuna pruriens Seed Extract for Neuroprotection in Parkinson's Disease

Chuda Chittasupho et al.

Summary: This study found that the extract of Mucuna pruriens seeds contains various phytochemical compounds, including natural L-dopa, which has superior efficiency compared with synthetic L-dopa. By preparing a nanogel containing the extract and incorporating it into a jelly formulation, a functional food for elderly patients with Parkinson's disease was successfully developed.

PHARMACEUTICS (2022)

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Review Cell Biology

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

Xuegang He et al.

Summary: Traumatic spinal cord injury (TSCI) causes neurological dysfunction and significantly affects the quality of life in patients. The PI3K/AKT signaling pathway is a potential therapeutic target for the inhibition of secondary TSCI. This review summarizes the role of the PI3K/AKT pathway in TSCI and discusses current and potential future treatment methods based on this pathway.

CELL PROLIFERATION (2022)

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Article Cell Biology

Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level

Haiyan Li et al.

Summary: Resveratrol (RSV) preconditioning can alleviate myocardial infarction/reperfusion injury by reducing infarct size, improving cardiac function, and reducing oxidative stress. The cardioprotective effects of RSV are mediated through the activation of the AMPK/SIRT1-FOXO1 signaling pathway and promotion of autophagy level.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Plant Sciences

Zuogui Wan slowed senescence of bone marrow mesenchymal stem cells by suppressing Wnt/?-catenin signaling

Xiangping Kang et al.

Summary: The study found that the traditional Chinese medicine Zuogui Wan (ZGW) has a delaying effect on the aging of bone marrow mesenchymal stem cells (BMSCs). ZGW achieves this by modulating the Wnt signaling pathway, suppressing the expression of age-related factors, promoting cell proliferation, improving DNA damage, and reducing the secretion of senescence-related factors (SASP).

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling

Xiaobo Wang et al.

Summary: Salidroside (Sal), an active compound from Rhodiola species, exerts neuroprotective effects against hypoxic brain injury by maintaining mitochondrial dynamics homeostasis through activation of the Sirt1/p53/Drp1 signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Endocrinology & Metabolism

Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway

Fuyuan Li et al.

Summary: This study investigates the protective mechanism of Salidroside (SAL) on cerebral ischemia reperfusion injury (CIRI) through regulating the Nrf2/Trx1 axis. Results showed that SAL effectively alleviates infarction rate, improves histopathological changes, and reduces apoptosis and oxidative stress in CIRI rats and PC12 cells. It also inhibits ASK1/MAPK and activates Nrf2/Trx1 signaling pathway.

METABOLIC BRAIN DISEASE (2022)

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Article Nutrition & Dietetics

Renoprotective Effect of Pediococcus acidilactici GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways

Wen-Hsin Lin et al.

Summary: In this study, the potential of Pediococcus acidilactici GKA4 (GKA4) to ameliorate acute kidney injury (AKI) was investigated using a cisplatin-induced animal model. GKA4 attenuated renal damage, reduced inflammation and lipid oxidation, and increased antioxidant levels in mice with cisplatin-induced nephrotoxicity. Furthermore, GKA4 modulated the expression of inflammation-related proteins and MAPK in kidney tissues, suggesting a therapeutic potential for AKI treatment.

NUTRIENTS (2022)

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Article Integrative & Complementary Medicine

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured HT22 cells

Sixia Yang et al.

Summary: Salidroside plays a neuroprotective role by inhibiting neuronal ferroptosis in A beta(1-42)-induced AD mice and Glu-injured HT22 cells through activation of the Nrf2/HO1 signaling pathway.

CHINESE MEDICINE (2022)

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Article Dermatology

Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent Autophagy

Jin Ke et al.

Summary: The study found that SAL pretreatment can improve cell viability and inhibit LDH release in UVB-challenged HaCaT cells. SAL can significantly reduce intracellular ROS levels and suppress oxidative stress, increase MDA content and enhance SOD activity. In addition, SAL pretreatment can enhance autophagy in UVB-irradiated HaCaT cells, increase protein expressions of Beclin-1 and ATG7, and decrease protein expression of P62. The study also found that pretreatment with SAL can increase the SIRT1 protein in irradiated HaCaT cells.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2022)

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Article Immunology

Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain

Wei Li et al.

Summary: This article summarizes the mechanisms of nerve damage and pain caused by excessive activation of the NLRP3 inflammasome.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Plant Sciences

Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway

Delong Pei et al.

Summary: The study demonstrates that SAL exerts a protective effect on STZ-induced DN in rats through the Akt/GSK-3 beta signalling pathway, improving renal function and alleviating inflammation and oxidative stress.

PHARMACEUTICAL BIOLOGY (2022)

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Article Agriculture, Dairy & Animal Science

Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway

Zhifu Cui et al.

Summary: The study demonstrated that SDS can inhibit lipid accumulation and hepatocyte apoptosis, promote hepatocyte proliferation through the PI3K/AKT/Gsk3-beta pathway in an OA-induced fatty liver model in vitro, while alleviating high-fat-diet-induced hepatic steatosis, oxidative stress, and inflammatory response in laying hens in vivo.

POULTRY SCIENCE (2022)

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Article Immunology

Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways

Qi Duan et al.

Summary: This study aimed to investigate the protective effects of Trametenolic acid (TA) on diabetic nephropathy (DN) and its underlying mechanism. The results showed that TA administration significantly alleviated renal histopathological changes and improved renal function in DN mice. Furthermore, TA activated the Nrf2/HO-1 signaling pathway, inhibited NF-kappa B signaling, and reduced inflammation. These findings suggest that TA exhibits renoprotective effects by ameliorating oxidative stress and inflammation.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Article Pharmacology & Pharmacy

Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression

Ziying Dai et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

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Article Medicine, Research & Experimental

Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production

Dan Song et al.

Summary: Salidroside attenuates acute lung injury by inhibiting inflammatory cytokine production, reducing LPS-induced pathological damage, and suppressing TNF-α and IL-6 secretion in the lung. This suggests that Salidroside may have a potential therapeutic effect in LPS-induced acute lung injury.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Genetics & Heredity

Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury

Ping Jin et al.

Summary: Salidroside (Sal) from Rhodiola rosea has a protective effect on rat hearts subjected to ischemia-reperfusion (I/R) injury, improving cardiac function, reducing infarct size, and inhibiting oxidative stress. Additionally, Sal treatment attenuates autophagy and apoptosis in the heart, potentially through the upregulation of circ-0000064 and inhibition of autophagy.

GENE (2021)

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Article Pharmacology & Pharmacy

Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection

Yan Tang et al.

Summary: Salidroside alleviates hypoxic injury in PC12 cells by inhibiting oxidative stress, anti-apoptosis, and enhancing mitochondrial energy synthesis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Pseudophosphatases as Regulators of MAPK Signaling

Emma Marie Wilber Hepworth et al.

Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-ΚB signaling pathway

Jie Liu et al.

Summary: Salidroside can inhibit NLRP3 inflammasome activation and reduce inflammatory injury by suppressing the TLR4/NF-κB signaling pathway, showing potential as a therapeutic drug for ischemic stroke.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Pharmacology & Pharmacy

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Qian Xie et al.

Summary: Natural products play a significant role in disease prevention and health promotion, especially for stroke. They modulate activities through multiple targets and signaling pathways for neuroprotection, making them suitable candidates for stroke treatment. Further exploration is needed to understand the structure-activity relationship of natural products in neuroprotection.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Oncology

Salidroside inhibits endothelial-mesenchymal transition via the KLF4/eNOS signaling pathway

Yongpan Huang et al.

Summary: This study revealed that SAL may inhibit Hcy-induced EndMT by regulating the KLF4/eNOS signaling pathway, thus improving the development of atherosclerosis.

MOLECULAR MEDICINE REPORTS (2021)

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Article Cell Biology

Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation

Weidong Ma et al.

Summary: Salidroside suppresses the proliferation and migration of human lung cancer cells by regulating the AMPK-dependent NLRP3 inflammasome.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Medicine, Research & Experimental

Salidroside inhibits chronic myeloid leukemia cell proliferation and induces apoptosis by regulating the miR-140-5p/wnt5a/β-catenin axis

Danjun Chen et al.

Summary: Salidroside, an active ingredient of Rhodiola rosea, shows antitumor effects in chronic myeloid leukemia (CML) by inhibiting cell proliferation and promoting apoptosis through regulation of miR-140-5p and suppression of the wnt5a/beta-catenin signaling pathway.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Pharmacology & Pharmacy

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression

Yang Fan et al.

Summary: The study found that treatment with Salidroside (SLDS) can reduce depressive behaviors in stress mice by inhibiting microglial activation and reducing the expression and release of neuroinflammatory cytokines. This suggests that SLDS may be a potential therapeutic approach for treating depression by interfering with microglia-mediated neuroinflammation.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Food Science & Technology

Protective effect of Salidroside on hypoxia-related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways

Yanlei Xiong et al.

Summary: Salidroside was found to alleviate high-altitude hypoxia-induced liver injury through antioxidant and anti-inflammatory pathways, by inhibiting pro-inflammatory cytokines release and increasing antioxidant enzyme activities. Additionally, it was shown to activate Nrf2-mediated antioxidant pathway and inhibit hepatic pro-inflammatory cytokines release through the JAK2/STAT3 pathway.

FOOD SCIENCE & NUTRITION (2021)

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Article Medicine, Research & Experimental

Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury

Cai-ying Hu et al.

Summary: The study demonstrates that salidroside can reduce neuronal death under cerebral ischemia conditions by safeguarding mitochondrial function, with the prevention of excessive mitochondrial fission being a key mechanism.

CURRENT MEDICAL SCIENCE (2021)

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Review Biochemistry & Molecular Biology

The JAK/STAT signaling pathway: from bench to clinic

Xiaoyi Hu et al.

Summary: The JAK/STAT signaling pathway is a crucial cellular signal transduction pathway, associated with various cancers and autoimmune diseases. Researchers discussed the composition, activation, and regulation of this pathway, as well as its role in diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Plant Sciences

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1 alpha signalling pathway in acute mountain sickness

Xiaoning Yan et al.

Summary: The study revealed that components of Rhodiola crenulata can induce metabolic reprogramming by regulating the Hif-1 alpha signaling pathway, activating compensatory responses. Microglia sensed low oxygen levels earlier than neurons, accompanied by elevated expression of Hif-1 alpha protein.

PHARMACEUTICAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Salidroside protects dopaminergic neurons by regulating the mitochondrial MEF2D-ND6 pathway in the MPTP/MPP+-induced model of Parkinson's disease

Tao Li et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Cell Biology

Salidroside Restores an Anti-inflammatory Endothelial Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress

Y. Wang et al.

INFLAMMATION (2020)

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Review Medicine, Research & Experimental

Anti-inflammatory effects of Rhodiola rosea L.: A review

Wei-ling Pu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease

Hualong Wang et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2020)

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Article Pharmacology & Pharmacy

Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

Rong Hu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Neurosciences

Systemic inflammation in traumatic spinal cord injury

Ona Bloom et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Cell Biology

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Xue Zhang et al.

AGING-US (2020)

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Article Oncology

Salidroside suppresses nonsmall cell lung cancer cells proliferation and migration via microRNA-103-3p/Mzb1

Xiaohong Zhu et al.

ANTI-CANCER DRUGS (2020)

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Article Biophysics

Salidroside induces apoptosis and triggers endoplasmic reticulum stress in human hepatocellular carcinoma

Shou-Yong Ding et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen

Xiuli Lin et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Immunology

Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats

Jung-Shun Lee et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Cell Biology

Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model

Saumitra Sen Singh et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cell Biology

Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury

Sisi Li et al.

AGING-US (2020)

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Article Biochemistry & Molecular Biology

Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway

Yanlei Xiong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Neurosciences

Salidroside shows anticonvulsant and neuroprotective effects by activating the Nrf2-ARE pathway in a pentylenetetrazol-kindling epileptic model

Yanfen Wu et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Neurosciences

Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson's disease- emphasizing the role of mitochondrial biogenesis

Vaibhavi Peshattiwar et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Medicine, Research & Experimental

Therapeutic Effects of Salidroside on Cognitive Ability in Rats with Experimental Vascular Dementia

Z. Tian et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Review Cell Biology

Metabolome Changes in Cerebral Ischemia

Tae Hwan Shin et al.

CELLS (2020)

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Article Medicine, Research & Experimental

Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway

Yan Wang et al.

LIFE SCIENCES (2020)

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Article Cell Biology

Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells

Xiangli Bai et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Pharmacology & Pharmacy

Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis

Zeping Xie et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Inhibitory effects of salidroside on MCF-7 breast cancer cells in vivo

An-Qi Sun et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Review Biotechnology & Applied Microbiology

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

Sachchida Nand Rai et al.

3 BIOTECH (2020)

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Review Biochemistry & Molecular Biology

Salidroside - Can it be a Multifunctional Drug?

Sri Krishna Jayadev Magani et al.

CURRENT DRUG METABOLISM (2020)

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Article Multidisciplinary Sciences

Effects of rhodioloside on the neurological functions of rats with total cerebral ischemia/reperfusion and cone neuron injury in the hippocampal CA1 region

Yue Zhang et al.

PEERJ (2020)

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Article Medicine, Research & Experimental

Salidroside can target both P4HB-mediated inflammation and melanogenesis of the skin

Xiu-Juan Ding et al.

THERANOSTICS (2020)

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Article Cell Biology

Protective effect of rhodioloside and bone marrow mesenchymal stem cells infected with HIF-1-expressing adenovirus on acute spinal cord injury

Xiao-Qin Ha et al.

NEURAL REGENERATION RESEARCH (2020)

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Article Oncology

NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver

Qiaoting Deng et al.

CANCER LETTERS (2019)

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Article Biochemistry & Molecular Biology

Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-B and MAPK Signaling Pathways

Rui Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biotechnology & Applied Microbiology

Salidroside represses proliferation, migration and invasion of human lung cancer cells through AKT and MEK/ERK signal pathway

Mei Ren et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Neurosciences

Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse Model

Sachchida Nand Rai et al.

NEUROTOXICITY RESEARCH (2019)

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Article Integrative & Complementary Medicine

Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway

Zhongsheng Zhu et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Cell Biology

Salidroside Reduces Inflammation and Brain Injury After Permanent Middle Cerebral Artery Occlusion in Rats by Regulating PI3K/PKB/Nrf2/NFκB Signaling Rather than Complement C3 Activity

X. Zhang et al.

INFLAMMATION (2019)

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Review Chemistry, Medicinal

Rhodiola and Salidroside in the Treatment of Metabolic Disorders

Xiang-Li Bai et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

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Article Cell Biology

Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy

Ruru Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Biotechnology & Applied Microbiology

Anti-gastric cancer effect of Salidroside through elevating miR-99a expression

Lin Yang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Review Oncology

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

Cornelia Braicu et al.

CANCERS (2019)

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Article Cell Biology

Salidroside promotes rat spinal cord injury recovery by inhibiting inflammatory cytokine expression and NF-B and MAPK signaling pathways

Yiji Su et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Endocrinology & Metabolism

Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation

Qi Feng et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2019)

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Article Pharmacology & Pharmacy

Neuroprotective Effects of Salidroside on Cerebral Ischemia/Reperfusion-Induced Behavioral Impairment Involves the Dopaminergic System

Zhi-feng Zhong et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Cell Biology

Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson's Disease

Dong-Mei Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Immunology

Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia

Xiangrong Liu et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Neurosciences

Salidroside mediated stabilization of Bcl -XL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Suryanarayan Biswal et al.

NEUROBIOLOGY OF DISEASE (2018)

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Article Chemistry, Medicinal

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Jiao Feng et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

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Article Pharmacology & Pharmacy

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

Tao Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Cell Biology

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

Tao Zheng et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Pharmacology & Pharmacy

Effect of Chlorogenic Acid Supplementation in MPTP-Intoxicated Mouse

Saumitra S. Singh et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Cell Biology

Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats

Yicong Wei et al.

INFLAMMATION (2017)

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Article Cell Biology

Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo

Lvyi Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Mucuna pruriens reduces inducible nitric oxide synthase expression in Parkinsonian mice model

Satyndra Kumar Yadav et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2017)

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Article Biochemistry & Molecular Biology

Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways

Jing Ni et al.

LIPIDS IN HEALTH AND DISEASE (2017)

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Article Oncology

Salidroside protects PC12 cells from Aβ1-40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway

Xujiao Huang et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Multidisciplinary Sciences

Production of three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside, using plant genes expressing in Escherichia coli

Daeun Chung et al.

SCIENTIFIC REPORTS (2017)

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Article Geriatrics & Gerontology

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson's Disease through NF-κB/pAKT Signaling Pathways

Sachchida N. Rai et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

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Article Pharmacology & Pharmacy

Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway

Linjie Ju et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Article Multidisciplinary Sciences

Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1

Kuo-Cheng Lan et al.

SCIENTIFIC REPORTS (2017)

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Review Genetics & Heredity

Cyclin D1, cancer progression, and opportunities in cancer treatment

Shuo Qie et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Article Cell Biology

Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy

Wei-Yong Yin et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2016)

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Article Neurosciences

Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress

Pei-Pei Si et al.

NEUROSCIENCE LETTERS (2016)

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Article Cell Biology

Adiponectin Protects against Glutamate-Induced Excitotoxicity via Activating SIRT1-Dependent PGC-1 alpha Expression in HT22 Hippocampal Neurons

Liang Yue et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Neurosciences

Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress

Kai Tao et al.

NEUROSCIENCE BULLETIN (2016)

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Article Neurosciences

Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer's disease

Bei Zhang et al.

TRANSLATIONAL NEURODEGENERATION (2016)

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Article Behavioral Sciences

Salidroside ameliorates cognitive impairment in a D-galactose-induced rat model of Alzheimer's disease

Jin Gao et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

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Article Neurosciences

Protective Effects of Salidroside in the MPTP/MPP+-Induced Model of Parkinson's Disease through ROS-NO-Related Mitochondrion Pathway

Songhai Wang et al.

MOLECULAR NEUROBIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress

Lingyun Xiao et al.

MOLECULES (2014)

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Article Biochemistry & Molecular Biology

Withania somnifera Alleviates Parkinsonian Phenotypes by Inhibiting Apoptotic Pathways in Dopaminergic Neurons

Jay Prakash et al.

NEUROCHEMICAL RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Comparison of the neuroprotective potential of Mucuna pruriens seed extract with estrogen in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model

Satyndra Kumar Yadav et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

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Pharmacological effects of salidroside on central nervous system diseases

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