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Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Summary: This study identified 16 common differentially expressed genes between AD and T2D, which were enriched in the biological processes of apoptosis, autophagy, inflammation, and hemostasis. The study also identified 5 hub proteins, 5 central regulatory transcription factors, and 6 microRNAs encoded by these genes.

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Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease

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Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer ' s cerebral pathology and clinical disease progression

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Recurrent non-severe hypoglycemia aggravates cognitive decline in diabetes and induces mitochondrial dysfunction in cultured astrocytes

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Review Neurosciences

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

Christian Holscher

NEUROPHARMACOLOGY (2018)

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Article Neurosciences

Characterization of Impaired Cerebrovascular Structure in APP/PS1 Mouse Brains

Kee-Chan Ahn et al.

NEUROSCIENCE (2018)

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Review Geriatrics & Gerontology

Deciphering the Astrocyte Reaction in Alzheimer's Disease

Beatriz G. Perez-Nievas et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Article Endocrinology & Metabolism

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

Sreemathi Logan et al.

MOLECULAR METABOLISM (2018)

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Article Geriatrics & Gerontology

Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice

Deborah J. Mi et al.

NEUROBIOLOGY OF AGING (2018)

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Review Biochemistry & Molecular Biology

Amino acid transporters revisited: New views in health and disease

Palanivel Kandasamy et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

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Article Multidisciplinary Sciences

Circulating microRNAs-192 and-194 are associated with the presence and incidence of diabetes mellitus

Andrea Jaeger et al.

SCIENTIFIC REPORTS (2018)

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Article Geriatrics & Gerontology

Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation

Wenjun Li et al.

AGING AND DISEASE (2018)

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Article Genetics & Heredity

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan et al.

NATURE GENETICS (2018)

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Review Medicine, Research & Experimental

Signaling Mechanisms of Selective PPAR gamma Modulators in Alzheimer's Disease

Manoj Govindarajulu et al.

PPAR RESEARCH (2018)

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Article Endocrinology & Metabolism

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

Aino Latva-Rasku et al.

DIABETES (2018)

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Review Immunology

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Yang Shi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes

Adrian Westhaus et al.

NEUROCHEMICAL RESEARCH (2017)

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Article Endocrinology & Metabolism

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

Ana M. Fernandez et al.

DIABETES (2017)

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Article Neurosciences

Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits

Peter J. Fried et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Neurosciences

Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

Ebrahim Haroon et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Article Geriatrics & Gerontology

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

Stefano Tarantini et al.

EXPERIMENTAL GERONTOLOGY (2017)

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Article Clinical Neurology

Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?

A. Knezovic et al.

JOURNAL OF NEURAL TRANSMISSION (2017)

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Article Neurosciences

ASTROCYTE TRANSPORT OF GLUTAMATE AND NEURONAL ACTIVITY RECIPROCALLY MODULATE TAU PATHOLOGY IN DROSOPHILA

Jason G. Kilian et al.

NEUROSCIENCE (2017)

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Article Biology

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity

Josien Levenga et al.

ELIFE (2017)

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Article Cell & Tissue Engineering

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Minna Oksanen et al.

STEM CELL REPORTS (2017)

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Article Clinical Neurology

High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes

Manpreet Bahniwal et al.

CURRENT ALZHEIMER RESEARCH (2017)

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Article Medicine, Research & Experimental

Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM

Janice J. Hwang et al.

JCI INSIGHT (2017)

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Review Biochemistry & Molecular Biology

Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal

Ramesh Kandimalla et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

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Article Biochemistry & Molecular Biology

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity

Jochen Martin Decker et al.

EMBO REPORTS (2016)

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Review Endocrinology & Metabolism

Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications

Caroline Pereira Domingueti et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2016)

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Article Cell Biology

Resistin impairs glucose permeability in EA.hy926 cells by down-regulating GLUT1 expression

Qiang Li et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2016)

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Article Biochemistry & Molecular Biology

Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats

Patricia Nardin et al.

NEUROCHEMICAL RESEARCH (2016)

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Article Endocrinology & Metabolism

Long-term central pathology and cognitive impairment are exacerbated in a mixed model of Alzheimer's disease and type 2 diabetes

Carmen Infante-Garcia et al.

PSYCHONEUROENDOCRINOLOGY (2016)

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Article Multidisciplinary Sciences

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Ab plaques by iGluSnFR two-photon imaging

J. K. Hefendehl et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes

Esther Fuente-Martin et al.

SCIENTIFIC REPORTS (2016)

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Review Medicine, Research & Experimental

Role of oxidative stress in Alzheimer's disease

Wen-Juan Huang et al.

BIOMEDICAL REPORTS (2016)

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Review Cell Biology

Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology

Makoto Ishii et al.

CELL METABOLISM (2015)

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Article Endocrinology & Metabolism

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

Claudia A. Grillo et al.

DIABETES (2015)

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Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

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Review Neurosciences

The role of type 2 diabetes in neurodegeneration

Giuseppe Verdile et al.

NEUROBIOLOGY OF DISEASE (2015)

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Review Toxicology

The Role of Astrocyte Mitochondria in Differential Regional Susceptibility to Environmental Neurotoxicants: Tools for Understanding Neurodegeneration

Laura L. Kubik et al.

TOXICOLOGICAL SCIENCES (2015)

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Article Biochemistry & Molecular Biology

Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes

Rahul Agrawal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

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Article Endocrinology & Metabolism

Astrocytic and microglial response in experimentally induced diabetic rat brain

Aarti Nagayach et al.

METABOLIC BRAIN DISEASE (2014)

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Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Chia-Chan Liu et al.

NATURE REVIEWS NEUROLOGY (2013)

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Review Endocrinology & Metabolism

The potential role of glutamate in the current diabetes epidemic

Alberto M. Davalli et al.

ACTA DIABETOLOGICA (2012)

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Review Biochemistry & Molecular Biology

Alzheimer Mechanisms and Therapeutic Strategies

Yadong Huang et al.

CELL (2012)

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Article Cardiac & Cardiovascular Systems

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

Susan Cheng et al.

CIRCULATION (2012)

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Article Endocrinology & Metabolism

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

Alena Stancakova et al.

DIABETES (2012)

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Article Neurosciences

Diabetes Impairs Cortical Plasticity and Functional Recovery Following Ischemic Stroke

Danielle Sweetnam et al.

JOURNAL OF NEUROSCIENCE (2012)

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Article Neurosciences

HIGH GLUCOSE-INDUCED EXPRESSION OF INFLAMMATORY CYTOKINES AND REACTIVE OXYGEN SPECIES IN CULTURED ASTROCYTES

J. Wang et al.

NEUROSCIENCE (2012)

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Article Cardiac & Cardiovascular Systems

IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: A study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects

G. Sesti et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2011)

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Article Neurosciences

Hyperglycaemia and diabetes impair gap junctional communication among astrocytes

Gautam K. Gandhi et al.

ASN NEURO (2010)

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Article Neurosciences

Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration

Elaine S. Coleman et al.

BRAIN RESEARCH (2010)

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Article Geriatrics & Gerontology

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Aileen M. Moloney et al.

NEUROBIOLOGY OF AGING (2010)

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Article Behavioral Sciences

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

Talib Abbas et al.

BEHAVIOURAL BRAIN RESEARCH (2009)

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Article Cell Biology

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Christopher B. Newgard et al.

CELL METABOLISM (2009)

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Article Clinical Neurology

The after-effect of human theta burst stimulation is NMDA receptor dependent

Ying-Zu Huang et al.

CLINICAL NEUROPHYSIOLOGY (2007)

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Article Pharmacology & Pharmacy

Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus

F Trudeau et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2004)

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Review Neurosciences

Molecular pharmacology of glutamate transporters, EAATs and VGLUTs

Y Shigeri et al.

BRAIN RESEARCH REVIEWS (2004)

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Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

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