期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 49, 页码 12468-12484出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1699-16.2016
关键词
auditory cortex; cochlear implant; marmoset
资金
- National Institutes of Health National Institute on Deafness and Other Communication Disorders Grat [R01DC014503, F31DC010321, P30 DC005211]
- Kleberg Foundation
Despite the success of cochlear implants (CIs) in human populations, most users perform poorly in noisy environments and music and tonal language perception. How CI devices engage the brain at the single neuron level has remained largely unknown, in particular in the primate brain. By comparing neuronal responses with acoustic and CI stimulation in marmoset monkeys unilaterally implanted with a CI electrode array, we discovered that CI stimulation was surprisingly ineffective at activating many neurons in auditory cortex, particularly in the hemisphere ipsilateral to the CI. Further analyses revealed that the CI-nonresponsive neurons were narrowly tuned to frequency and sound level when probed with acoustic stimuli; such neurons likely play a role in perceptual behaviors requiring fine frequency and level discrimination, tasks that CI users find especially challenging. These findings suggest potential deficits in central auditory processing of CI stimulation and provide important insights into factors responsible for poor CI user performance in a wide range of perceptual tasks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据