☆ 4.7 Review

Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

High glucose stimulating ECM remodeling and an inflammatory phenotype in the IPFP via upregulation of MFAP5 expression

Xiao-ying Dong et al.

Summary: This study found that diabetes worsens fibrosis and inflammation in the IPFP through the upregulation of MFAP5 expression and modulation of Pdgfr alpha(+) progenitor cells. MFAP5 may be a potential novel therapeutic target for diabetes-induced osteoarthritis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Cell Biology

CRISPR/Cas9-mediated knockout of SGLT1 inhibits proliferation and alters metabolism of gastric cancer cells

Min Shi et al.

Summary: The study found that the expression of SGLT1 in gastric cancer was positively associated with tumor staging, histological differentiation, and overall survival rate. Knockout of SGLT1 could inhibit cell proliferation, promote apoptosis, and alter metabolism in gastric cancer cells. Mechanistically, the transcription activity of SGLT1 could be negatively regulated by p53.

CELLULAR SIGNALLING (2022)

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Article Endocrinology & Metabolism

Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction

Inga Kavazovic et al.

Summary: Type 2 diabetes leads to impaired antiviral and anticancer capacity of memory CD8 T cells due to hyperglycemia, rather than hyperinsulinemia, in the context of obesity.

DIABETES (2022)

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Article Biochemistry & Molecular Biology

MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways

Lavanya Ponnusamy et al.

Summary: MARK2 is significantly upregulated in breast cancer tissues and its high expression is associated with poor survival. Deletion or inhibition of MARK2 suppresses aerobic glycolysis and cell growth, and induces cell cycle arrest and apoptosis in breast cancer cells. MARK2 promotes breast cancer development by regulating mTOR/HIF-1α and p53 signaling pathways.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Immunology

Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication

Marta De Angelis et al.

Summary: Influenza virus infection reduces G6PD expression and activity, leading to increased oxidative stress and virus replication. Modulation of G6PD during viral infection may affect redox homeostasis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Combination of berberine and low glucose inhibits gastric cancer through the PP2A/GSK3β/MCL-1 signaling pathway

Ze Peng et al.

Summary: The combination of berberine and low glucose can inhibit the growth of gastric cancer through the activation of the PP2A/GSK38/MCL-1 signaling pathway, making it a new safe and effective anti-cancer therapy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Infectious Diseases

J-shaped associations and joint effects of fasting glucose with inflammation and cytokines on COVID-19 mortality

Xuefeng Lai et al.

Summary: This study investigated the dose-response relationship of admission fasting glucose with COVID-19 mortality, as well as potential interactions of hyperglycemia with inflammation and hypercoagulation on COVID-19 outcomes. The findings showed J-shaped associations between FBG and outcomes, with significant joint effect trends observed in patients with hyperglycemia and high levels of inflammatory and coagulation markers.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA Repair

Griffin M. Wright et al.

Summary: Dysregulation of DNA repair is a characteristic of cancer. This study identifies STAT3 as a novel transcriptional regulator of XRCC1 in triple-negative breast cancers. Glucose challenge increases STAT3 activation, promoting XRCC1 expression in different cell types. Prolonged exposure to high glucose leads to overexpression of XRCC1, which can be reversed by restricting glucose intake and down-regulating STAT3 activation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

Feedback amplification of senolysis using caspase-3-cleavable peptide-doxorubicin conjugate and 2DG

Jong Cheol Lee et al.

Summary: This study introduces a novel strategy combining radiation-induced apoptosis-targeted chemotherapy with a glycolysis inhibitor to target therapy-induced senescence. The combination therapy has shown promising results in overcoming therapy-induced senescence and inhibiting tumor growth.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Medicine, Research & Experimental

Glycolytic inhibitor 2-deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

Anant Narayan Bhatt et al.

Summary: The glycolytic inhibitor 2-DG inhibits the replication of SARS-CoV-2 and reduces cytopathic effects in infected cells. It also leads to un-glycosylation of the spike protein, resulting in the production of defective progeny virions with compromised infective potential.

LIFE SCIENCES (2022)

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Review Endocrinology & Metabolism

Metformin: Is it a drug for all reasons and diseases?

Chris R. Triggle et al.

Summary: Metformin, a commonly used drug for type 2 diabetes, has shown potential therapeutic effects for other diseases such as polycystic ovary syndrome, cancer, and neurodegenerative diseases. However, there is still debate on whether metformin is effective for all diseases and whether its benefits are solely due to its anti-hyperglycemic and insulin-sensitizing effects.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Article Endocrinology & Metabolism

Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway

Tongtong Qiu et al.

Summary: Our study found that obesity-induced excessive palmitic acid can promote inflammation and glucose metabolism disorders through the GPRs/NF-kappa B/KLF7 signaling pathway.

NUTRITION & DIABETES (2022)

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Article Oncology

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

Jernej Repas et al.

Summary: The combination of metformin and 2-deoxy-D-glucose can increase mitochondrial mass in triple-negative breast cancer cells and reduce the levels of immune checkpoint protein PD-L1.

CANCERS (2022)

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Article Oncology

Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer

Tsung-Ching Lai et al.

Summary: This study identified that the antipsychotic drug penfluridol inhibits the growth of lung cancer cells by reducing ATP production from mitochondria and altering energy metabolism-related proteins. Additionally, the inhibitory effect of penfluridol on cancer cell growth is enhanced by a glycolysis inhibitor. Penfluridol reduces energy production by inhibiting critical regulators of mitochondrial biogenesis, the SIRT1/PGC-1α axis.

CANCERS (2022)

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Article Cell Biology

Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients

Maria Elena Soto et al.

Summary: Infection with SARS-CoV-2 affects the glucose-insulin axis and leads to changes in glucose metabolism in COVID-19 patients, resulting in the loss of redox homeostasis and increased oxidative and nitrosative stress.

CELLS (2022)

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Review Biochemistry & Molecular Biology

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

Manuel Garcia-Saenz et al.

Summary: Metformin, as a first-line therapy for Type 2 Diabetes, not only improves insulin sensitivity and reduces hepatic gluconeogenesis, but also has pleiotropic effects like reducing cancer risk and tumorigenesis. However, its effect on thyroid cancer remains controversial. Preclinical studies have shown potential mechanisms for its growth inhibitory effects through various pathways.

BIOMOLECULES (2022)

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Article Neurosciences

Caloric Restriction Mimetic 2-Deoxyglucose Reduces Inflammatory Signaling in Human Astrocytes: Implications for Therapeutic Strategies Targeting Neurodegenerative Diseases

Kaylie-Anna Juliette Vallee et al.

Summary: Therapeutic interventions for age-related neurodegenerative diseases are greatly needed. This study investigated how a caloric restriction mimetic and glycolysis inhibitor, 2-deoxyglucose (2-DG), affects interleukin 1 beta-induced inflammatory gene expression in human astrocytes. The results showed that inhibiting glycolysis in human astrocytes reduces IL-1 beta-induced reactivity, suggesting a potential therapeutic strategy for limiting inflammation and enhancing bioenergetics to prevent and treat neurodegenerative diseases.

BRAIN SCIENCES (2022)

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Article Pharmacology & Pharmacy

2-Deoxy-D-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation

Ikuno Uehara et al.

Summary: Targeted therapies that inhibit cytokine receptor glycosylation have been shown to be effective in treating various inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2022)

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Article Genetics & Heredity

Enhanced endocytosis elevated virulence and severity of SARS-CoV-2 due to hyperglycemia in type 2 diabetic patients

Kannan Subbaram et al.

Summary: This review investigates the virulence of SARS-CoV-2 and the severity of COVID-19 in type 2 diabetes mellitus patients. It is found that hyperglycemic individuals with diabetes mellitus are more susceptible to SARS-CoV-2 infection and replication, leading to a cytokine storm and respiratory insufficiency. Type 2 diabetes mellitus also weakens the immune system, making patients prone to opportunistic infections. Proper glycemic control may help lessen the severity of COVID-19 in patients with diabetes mellitus.

GENE REPORTS (2022)

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Review Medicine, Research & Experimental

COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality

Prateek Sharma et al.

Summary: Diabetes is associated with an increased risk and severity of COVID-19, and the virus may directly harm the pancreas and lead to the development of diabetes in previously non-diabetic individuals. It is important to control blood glucose levels, reduce hospitalizations, consider nutritional factors, and recommend immunization to mitigate the bidirectional association between COVID-19 and diabetes.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Endocrinology & Metabolism

Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment

Yifei Zhu et al.

Summary: Cancer cells adapt to harsh environments by altering their metabolism, and metabolic reprogramming in the tumor microenvironment can regulate tumor progression. Cancer-associated fibroblasts (CAFs) play a significant role in tumorigenesis and progression through their involvement in metabolic reprogramming. The relationship between CAFs and immune cells, as well as the implications of metabolic reprogramming, requires further investigation.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Cell Biology

The combination of hydroxychloroquine and 2-deoxyglucose enhances apoptosis in breast cancer cells by blocking protective autophagy and sustaining endoplasmic reticulum stress

Ning Zhou et al.

Summary: HCQ combined with 2-DG can further inhibit the viability and migration of breast tumor cells and induce apoptosis. In vivo experiments have shown that the combination of 2-DG and HCQ significantly reduces tumor size and metastasis. This study deepens the research interest in metabolic disruptors for triple-negative breast cancer and emphasizes the potential of the combination of 2-DG and HCQ as an anticancer treatment.

CELL DEATH DISCOVERY (2022)

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Article Biochemistry & Molecular Biology

Energy Substrate Transporters in High-Grade Ovarian Cancer: Gene Expression and Clinical Implications

Marta Baczewska et al.

Summary: The study aimed to assess the dominant energy substrate transport mechanism in ovarian cancer cells and predict clinical outcomes using genomic aberrations. The researchers found differential gene expression in high-grade serous carcinoma and suggested the potential use of glucose and lactate transport as therapeutic targets to impede ovarian cancer growth.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic Viruses

Beata Pajak et al.

Summary: Viral infection triggers metabolic changes in cells, particularly an upregulation of glycolysis. The glycolysis inhibitor 2-DG has been studied as an antiviral drug, but its pharmacokinetic properties limit its application.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

High Glucose Accelerates Tumor Progression by Regulating MEDAG-Mediated Autophagy Levels in Breast Cancer

Chenyuan Li et al.

Summary: Recent studies have shown that diabetes is a major risk factor for breast cancer, but the mechanism is not fully understood. This study found a relationship between mesenteric estrogen-dependent adipogenesis and breast cancer under high glucose conditions, and the MEDAG-AMPK-autophagy axis plays a vital role in breast cancer progression in diabetic patients.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Medicine, Research & Experimental

Hypoxia-inducible factors: cancer progression and clinical translation

Elizabeth E. Wicks et al.

Summary: This review presents the mechanisms and consequences of hypoxia-inducible factor (HIF) activation in cancer cells, and discusses the current status and future prospects of small-molecule HIF inhibitors as cancer therapeutics.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Nutrition & Dietetics

Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet

Carla Iacobini et al.

Summary: Carbonyl stress refers to the increase in reactive carbonyl species and the formation of irreversible covalent adducts with biological molecules. It is associated with inflammation and damage, and plays a role in diabetic cardiovascular complications, cancer risk, and the impact of modern diet on cardiometabolic and cancer risk.

NUTRIENTS (2022)

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Review Oncology

Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks

Nikita Lvanisenko et al.

Summary: This article discusses the role and regulatory mechanisms of cellular FLICE inhibitory protein (c-FLIP) in the extrinsic pathway of cancer networks. In addition to its key role in apoptosis, c-FLIP may regulate other cellular functions and serve as a therapeutic target for cancer treatment.

TRENDS IN CANCER (2022)

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Article Endocrinology & Metabolism

Blood glucose and epicardial adipose tissue at the hospital admission as possible predictors for COVID-19 severity

G. Guarisco et al.

Summary: The study found a possible association between blood glucose levels and volume of epicardial adipose tissue (EAT) at admission, and severe outcomes in COVID-19 patients. Both blood glucose and EAT were identified as potentially important factors for severe complications of Covid-19.

ENDOCRINE (2022)

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Article Endocrinology & Metabolism

Association of blood glucose level and prognosis of inpatients with coexistent diabetes and COVID-19

Weiwei Duan et al.

Summary: The study shows that well-controlled blood glucose levels in the first 7 days of hospitalized T2D patients can improve the prognosis of COVID-19.

ENDOCRINE (2022)

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Article Cell Biology

High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro

Jaclyn Iannucci et al.

Summary: Diabetes is closely related to the development of Alzheimer's disease (AD), and the mechanisms for this connection are not yet clear. This study investigates the impact of diabetes-related insults (glucose and hypoxia) on brain endothelial cells and their influence on microglia activation and inflammation. The findings suggest that the cerebral microcirculation plays a critical role in the harmful effects of diabetes in the AD brain.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

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Review Food Science & Technology

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Domenico Sergi et al.

Summary: AGEs are a group of molecules produced through non-enzymatic reactions, implicated in complications of diabetes and metabolic health, contributing to the development of type 2 diabetes and obesity.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Gastroenterology & Hepatology

Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice

Kyo Sasaki et al.

Summary: The newly developed 2DG-PLGA-NPs demonstrated cytotoxic and antitumor immunity effects in liver tumors in mice, showcasing their potential for future clinical applications.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Biochemistry & Molecular Biology

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response

Philippe Icard et al.

Summary: The current mortality due to Covid-19 pandemic highlights the lack of effective treatment, with research suggesting that the replication of SARS-CoV-2 may rely on altered glucose metabolism similar to the Warburg effect in cancer. Inhibiting two key signaling pathways that sustain aerobic glycolysis could potentially inhibit virus replication. Understanding the role of the Warburg effect in Covid-19 could be crucial in developing strategies to reduce infectivity and immune response.

BIOCHIMIE (2021)

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Review Cell Biology

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

Daniel J. Drucker

Summary: The increased prevalence of obesity, diabetes, and cardiovascular risk factors in severe COVID-19 patients has sparked interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology. This update focuses on how metabolic disorders and their co-morbidities affect susceptibility, natural history, and treatment of SARS-CoV-2 infection in individuals with obesity and diabetes. New data on genetics, epidemiology, immune responses, disease severity, and therapy are highlighted, informing our understanding of COVID-19 in this vulnerable population.

CELL METABOLISM (2021)

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Article Cell Biology

Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes

Bo Yu et al.

Summary: Insulin treatment for patients with COVID-19 and T2D was found to be associated with a significant increase in mortality according to a retrospective study. Further analysis showed that insulin treatment was linked to enhanced systemic inflammation and aggravated injuries of vital organs, suggesting that caution should be exercised when using insulin treatment for these patients.

CELL METABOLISM (2021)

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Editorial Material Cell Biology

Glucose or Insulin, Which Is the Culprit in Patients with COVID-19 and Diabetes?

Marc Y. Donath

Summary: Patients with metabolic syndrome have a poor prognosis when infected with SARS-CoV-2, and insulin therapy may increase fatality in patients with COVID-19 and diabetes.

CELL METABOLISM (2021)

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Review Medicine, Research & Experimental

Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara et al.

Summary: Viruses consist of a nucleic acid genome and a protein coat, with enveloped viruses having a lipid bilayer membrane. Virus-infected host cells show increased glutamine utilization and metabolism, which is essential for energy production and synthesis of macromolecules necessary for virus assembly.

CLINICAL SCIENCE (2021)

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Article Biophysics

Research on endoplasmic reticulum-targeting fluorescent probes and endoplasmic reticulum stress-mediated nanoanticancer strategies: A review

Li Qiao et al.

Summary: The endoplasmic reticulum (ER) plays crucial roles in protein synthesis, lipid biosynthesis, and calcium homeostasis, making it an important target for diagnosing and treating diseases. Excessive ER stress (ERS) has a killing effect on malignant cells and can mediate cell apoptosis, providing new perspectives for treatment of diseases, including cancer. Targeting ER and proper modulation of ERS are potential strategies in cancer therapy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Medicine, Research & Experimental

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

Chuyi Tan et al.

Summary: Inhibition of aerobic glycolysis protects against sepsis-induced AKI by promoting autophagy via the lactate/SIRT3/AMPK pathway. Sepsis or LPS enhance aerobic glycolysis, while the inhibitor 2-DG downregulates glycolysis and improves kidney injury induced by sepsis by enhancing cellular autophagy.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Nutrition & Dietetics

Adenovirus-36 as one of the causes of obesity: the review of the pathophysiology

Ana Carolina Lobor Cancelier et al.

Summary: The worldwide increase in obesity may be influenced by external factors independent of traditional causes, with one hypothesis suggesting person-to-person transmission like infectious diseases. The human adenovirus-36 (Adv36) has been found to be correlated with overweight/obesity in studies, due to its ability to accelerate adipocyte formation and lipid concentration.

NUTRITION RESEARCH (2021)

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Article Multidisciplinary Sciences

LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation

Monira Obaid et al.

Summary: The study demonstrates that during inflammation, HOTAIR plays a key role in regulating Glut1 expression and glucose uptake by activating NF-kB, thereby controlling metabolic programming in immune cells.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Diabetes and Pancreatic Cancer-A Dangerous Liaison Relying on Carbonyl Stress

Stefano Menini et al.

Summary: Diabetic individuals have an increased risk of developing various cancers, particularly pancreatic cancer, due to carbonyl stress caused by the higher availability of glucose and lipids. AGE formation and inhibition play a critical role in tumor development, suggesting a potential drug target. Caronyl stress is associated with the risk of pancreatic cancer in humans and may be a mechanistic link between diabetes and cancer development.

CANCERS (2021)

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Article Multidisciplinary Sciences

Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells

Jernej Repas et al.

Summary: The study found that the combined treatment with metformin and 2DG leads to detachment of MDA-MB-231 breast cancer cells, helping the cells adapt to energy stress. Detached cells have specific metabolic differences compared to attached cells, with higher levels of NADPH and lower levels of fatty acids and glutamine, and the metabolic profile of detached cells is closer to the untreated control cells. Metformin-treated cells show higher levels of fatty and amino acids and lower levels of purine nucleotides, which contributes to understanding the anticancer mechanisms of metformin.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer

Caiyu Lin et al.

Summary: The activation of ALK in ALK(+) NSCLC leads to elevated glycolysis levels, contributing to insensitivity to crizotinib. The study reveals that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK(+) NSCLC cells to crizotinib, and 2DG may sensitize these cells to crizotinib through suppression of HK2-mediated glycolysis and the AKT/mTOR signaling pathway.

THORACIC CANCER (2021)

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Review Oncology

Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

Farnaz Khodabakhsh et al.

Summary: VEGF and its receptor family play significant roles in pathological processes such as angiogenesis in tumor growth and metastasis. Overexpression of MUC1 on tumor cells leads to upregulation of various signaling pathways related to growth and survival.

CANCER CELL INTERNATIONAL (2021)

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Article Microbiology

Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism

Khyati Girdhar et al.

Summary: Viral infections manipulate host metabolic pathways to increase replication and mimic host hormones to affect the endocrine system. These mechanisms create a multidimensional network of interactions between host and viral proteins.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Review Neurosciences

Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer's Disease

Angeles Vinuesa et al.

Summary: Overnutrition and diets high in saturated fat contribute to inflammation and metabolic disturbances, leading to an increased risk for conditions like Alzheimer's disease. Understanding the interplay between inflammation and insulin resistance may offer potential therapeutic targets to prevent neurodegeneration and cognitive impairment.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Oncology

Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Donna L. Nile et al.

Summary: The combination of 2-DG with metformin significantly enhances the radiosensitising effect on neuroblastoma cells, inducing widespread cell death by disrupting cell metabolism. This dual metabolic targeting approach shows promise in improving clinical outcomes for high-risk pediatric patients.

CANCER & METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose

Kenji Kishimoto et al.

Summary: Metabolic reprogramming is suggested to contribute to the pathophysiology of rheumatoid arthritis, with glycolysis changes in synovial cells during early inflammation stages. Inhibitors of glycolysis can reverse these changes, highlighting potential therapeutic interventions.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Review Oncology

The prognostic outcome of 'type 2 diabetes mellitus and breast cancer' association pivots on hypoxia-hyperglycemia axis

Ilhaam Ayaz Durrani et al.

Summary: Type 2 diabetes mellitus and breast cancer are complex diseases with shared risk factors and phenotypic features. The exact molecular nature of their association remains to be fully elucidated, highlighting the critical role of HIF1 signaling in patients with both conditions and the potential therapeutic implications of targeting HIF1.

CANCER CELL INTERNATIONAL (2021)

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Article Immunology

Inhibiting Glucose Metabolism Results in Herpes Simplex Encephalitis

Engin Berber et al.

Summary: Treatment with 2DG accelerates the development of HSV-induced encephalitis, prolongs viral replication in TG cells, reduces the numbers and activation of inflammatory cells and T cells, and accelerates the breakdown of latent infection in TG cells already established.

JOURNAL OF IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

Milica Kosic et al.

Summary: The study showed that 3-methyladenine (3MA) can prevent cancer cell death induced by energy stress through autophagy-independent mechanisms, possibly involving JNK suppression and decrease of oxidative stress. It highlights the need for caution when using 3MA as an autophagy inhibitor.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Review Cell Biology

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors

Jing Dai et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 poses a threat to global economy and public health, with various receptors identified as potential mediators of virus infection. Higher H2S levels have been associated with better survival rates in COVID-19 patients, suggesting a potential role for H2S in modulating virus receptors and patient outcomes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Multidisciplinary Sciences

HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis

Fang Zhang et al.

Summary: Inflammation is crucial for pathogen clearance, but excessive inflammation can lead to diseases like cancer and sepsis. The HIPK2-HDAC3-p65 module in macrophages functions to restrain excessive inflammation, potentially offering a new therapeutic mechanism for colitis-associated colorectal cancer and sepsis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Oncology

Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes

Hsiu-Chung Cheng et al.

Summary: Diabetes mellitus and hyperglycemia significantly affect the incidence, chemoresistance, and prognosis of colorectal cancer through inflammation, endocrine effects, and metabolic imbalance. Metformin shows potential as a chemopreventive agent, but its effects on cancer prognosis remain controversial. Genetic factors and epigenetic modifications also play a role in the relationship between diabetes, colorectal cancer risk, and prognosis.

TRANSLATIONAL ONCOLOGY (2021)

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Article Virology

Metabolic shifts modulate lung injury caused by infection with H1N1 influenza A virus

Katherine E. Nolan et al.

Summary: This study found that inhibiting glycolysis worsens outcomes of influenza infection, while promoting TCA cycle flux and inhibiting OXPHOS can mitigate the effects of the virus. These findings suggest that a shift to glycolysis may be host-protective in influenza.

VIROLOGY (2021)

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Review Virology

The IGF-1 Signaling Pathway in Viral Infections

Agata Jozefiak et al.

Summary: IGF-1 activates intracellular signaling pathways by binding to IGF-1R, including PI3K/AKT and MAPK pathways, to regulate cell proliferation and apoptosis. The IGF-1 signaling also promotes cell differentiation and proliferation through the Ras/MAPK pathway.

VIRUSES-BASEL (2021)

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Article Medicine, Research & Experimental

Metabolic preconditioning in CD4+T cells restores inducible immune tolerance in lupus-prone mice

Christopher S. Wilson et al.

Summary: The study suggests that targeting glucose and mitochondrial metabolism can enable endogenous immune tolerance mechanisms to respond to tolerance induction in an animal model of lupus, potentially restoring durable immune tolerance and offering a new approach for autoimmune and transplant settings.

JCI INSIGHT (2021)

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Review Biochemistry & Molecular Biology

Insulin Resistance and Cancer: In Search for a Causal Link

Eusebio Chiefari et al.

Summary: Insulin resistance is closely associated with type 2 diabetes mellitus and cancer, potentially promoting tumorigenesis through hyperinsulinemia, visceral adiposity dysfunction, systemic inflammation, and epigenetic modifications. The gut microbiota and certain antidiabetic medications also play intriguing roles in the development of IR-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Crosstalk between hypoxia-sensing ULK1/2 and YAP-driven glycolysis fuels pancreatic ductal adenocarcinoma development

Yu Jia et al.

Summary: The study reveals that ULK1/2 enhances hypoxic glycolysis in PDAC cells by promoting PKM2, leading to increased cell proliferation and tumor growth in mice. Combination therapy of ULK1/2 inhibitors with 2-DG or 3-BP shows antineoplastic efficacy in CDX and PDX models.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

NAD plus depletion radiosensitizes 2-DG-treated glioma cells by abolishing metabolic adaptation

Xiaolin Shi et al.

Summary: This study found that 2-DG triggered metabolic adaption in U87 glioma cells by up-regulating NAMPT and cellular NAD+ content, which abolished the potential radiosensitizing effect of 2-DG. NAD+ depletion induced notable oxidative stress and re-radiosensitized 2-DG-treated glioma cells, especially in IDH1 mutant cells. Targeting NAD+ could radiosensitize gliomas with GR, and 2-DG administration might benefit tumor patients with IDH1 mutation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression

James M. Arnold et al.

ONCOGENE (2020)

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Article Biochemistry & Molecular Biology

Differential contribution of possible pattern-recognition receptors to advanced glycation end product-induced cellular responses in macrophage-like RAW264.7 cells

Masahiro Watanabe et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2020)

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Article Oncology

Lactic acid promotes macrophage polarization through MCT-HIF1α signaling in gastric cancer

Lan Zhang et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B. Pajak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia

Nina E. Murugina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Endocrinology & Metabolism

Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic β-cell mass and function

Yeoree Yang et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

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Review Medicine, Research & Experimental

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

Livan Delgado-Roche et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

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Article Cell Biology

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Lihua Zhu et al.

CELL METABOLISM (2020)

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Article Endocrinology & Metabolism

Diabetes is a risk factor for the progression and prognosis of COVID-19

Weina Guo et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2020)

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Article Ophthalmology

Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis

Rebecca Francis et al.

EXPERIMENTAL EYE RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Glycolysis - a key player in the inflammatory response

Gonzalo Soto-Heredero et al.

FEBS JOURNAL (2020)

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Article Pharmacology & Pharmacy

Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment

Yong Li et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

Mohamed Abu-Farha et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Virology

Multifaceted Functions of Host Cell Caveolae/Caveolin-1 in Virus Infections

Yifan Xing et al.

VIRUSES-BASEL (2020)

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Article Endocrinology & Metabolism

Apolipoprotein M overexpression through adeno-associated virus gene transfer improves insulin secretion and insulin sensitivity in Goto-Kakizaki rats

Yang Yu et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

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Article Oncology

Sitagliptin affects gastric cancer cells proliferation by suppressing Melanoma-associated antigen-A3 expression through Yes-associated protein inactivation

Qi Wang et al.

CANCER MEDICINE (2020)

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Article Immunology

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

Adnan Shah

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

Ying Zhang et al.

ANTIOXIDANTS (2020)

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Review Chemistry, Multidisciplinary

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Yuan Huang et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Review Oncology

Antiangiogenic therapies for pheochromocytoma and paraganglioma

Camilo Jimenez et al.

ENDOCRINE-RELATED CANCER (2020)

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Article Immunology

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

Stefanie Y. Tan et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Clinical Neurology

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Derek Kellar et al.

LANCET NEUROLOGY (2020)

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Review Chemistry, Medicinal

Pattern recognition receptor-mediated inflammation in diabetic vascular complications

Xu Wang et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Article Oncology

Rac1 repression reverses chemoresistance by targeting tumor metabolism

Shanmugasundaram Ganapathy-Kanniappan

CANCER BIOLOGY & THERAPY (2020)

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Article Medicine, General & Internal

New-Onset Diabetes in Covid-19

Francesco Rubino et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion

Fariborz Parandeh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders

Nour-Mounira Z. Bakkar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors

Yangke Wanyan et al.

MOLECULES (2020)

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Article Immunology

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Shigeru Iwata et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer

Yanqing Li et al.

ONCOTARGETS AND THERAPY (2020)

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Article Multidisciplinary Sciences

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

Shawn P. Kubli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Geriatrics & Gerontology

The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging

Thibault Teissier et al.

BIOGERONTOLOGY (2019)

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Article Oncology

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy et al.

CANCER CELL (2019)

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Article Oncology

Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Amanda Valeta-Magara et al.

CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells

Mengjia He et al.

ONCOGENE (2019)

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Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Hyperglycemia promotes Snail-induced epithelial-mesenchymal transition of gastric cancer via activating ENO1 expression

Xin Xu et al.

CANCER CELL INTERNATIONAL (2019)

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Article Multidisciplinary Sciences

KRAS4A directly regulates hexokinase 1

Caroline R. Amendola et al.

NATURE (2019)

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Review Oncology

The Roles of Sirtuin Family Proteins in Cancer Progression

Erhu Zhao et al.

CANCERS (2019)

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Article Immunology

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

Sofia Pavlou et al.

BMC IMMUNOLOGY (2018)

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Article Oncology

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

Audrey Berthe et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

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Article Oncology

Inhibition of FASN and ERα signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism

H. A. Zielinska et al.

CANCER LETTERS (2018)

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Article Cell Biology

Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress

Sardar Sindhu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Pathology

The breast tumor microenvironment: role in cancer development, progression and response to therapy

Suruchi Mittal et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Article Biochemistry & Molecular Biology

UDP-sugar accumulation drives hyaluronan synthesis in breast cancer

Sanna Oikari et al.

MATRIX BIOLOGY (2018)

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Article

Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages

Amber E. de Groot et al.

Oncotarget (2018)

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Review Medicine, Research & Experimental

Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

Biplab Giri et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Virology

Redox Biology of Respiratory Viral Infections

Olga A. Khomich et al.

VIRUSES-BASEL (2018)

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Article Multidisciplinary Sciences

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

Maik Luu et al.

SCIENTIFIC REPORTS (2018)

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Review Biochemistry & Molecular Biology

Effects of tumor metabolic microenvironment on regulatory T cells

Yi-an Wang et al.

MOLECULAR CANCER (2018)

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Review Neurosciences

Impact of Metabolic Syndrome on Neuroinflammation and the Blood-Brain Barrier

Peter Van Dyken et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Cell Biology

TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer

Katarzyna Gawel-Beben et al.

CELL BIOLOGY INTERNATIONAL (2018)

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Article Biochemistry & Molecular Biology

2-Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT-1 Dependent Mechanism

Haritha Kunhiraman et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Oncology

Hyperglycemia triggers HIPK2 protein degradation

Silvia Baldari et al.

ONCOTARGET (2017)

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Article Cell Biology

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

Hengqiang Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Multidisciplinary Sciences

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

W. K. Eddie Ip et al.

SCIENCE (2017)

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Review Oncology

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

Jennifer Peyling Wang et al.

JOURNAL OF CANCER (2017)

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Review Pharmacology & Pharmacy

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

Sachin V. Suryavanshi et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Review Oncology

The Rac GTPase in Cancer: From Old Concepts to New Paradigms

Marcelo G. Kazanietz et al.

CANCER RESEARCH (2017)

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Review Pediatrics

What is a normal blood glucose?

Maria Gueemes et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2016)

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Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

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Article Biochemistry & Molecular Biology

Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis

Timothy J. LaRocca et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Oncology

Seesaw of matrix metalloproteinases (MMPs)

Charu Kapoor et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2016)

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Review Medicine, Research & Experimental

Hypoxia-inducible factors: a central link between inflammation and cancer

Daniel Triner et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Endocrinology & Metabolism

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Manoela Mota et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

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Article Cell Biology

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

Tarique Hussain et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Pharmacology & Pharmacy

Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway

Labanyamoy Kole et al.

PHARMACOLOGICAL REPORTS (2016)

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Article Oncology

High glucose and insulin enhance uPA expression, ROS formation and invasiveness in breast cancer-derived cells

Luis Antonio Flores-Lopez et al.

CELLULAR ONCOLOGY (2016)

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Review Geriatrics & Gerontology

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

Xiaoting Luo et al.

AGING AND DISEASE (2016)

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Article Multidisciplinary Sciences

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

Kiminori Sada et al.

PLOS ONE (2016)

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Review Oncology

Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism

Angela M. Otto

CANCER & METABOLISM (2016)

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Article Oncology

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

Jeong Yong Jeon et al.

BMC CANCER (2015)

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Article Biochemistry & Molecular Biology

Inhibition of hyperglycemia-induced angiogenesis and breast cancer tumor growth by systemic injection of microRNA-467 antagonist

Irene Krukovets et al.

FASEB JOURNAL (2015)

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Article Oncology

Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling

Jianjun Han et al.

GYNECOLOGIC ONCOLOGY (2015)

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Article Medicine, Research & Experimental

The anti-angiogenic action of 2-deoxyglucose involves attenuation of VEGFR2 signaling and MMP-2 expression in HUVECs

I-Chen Chuang et al.

LIFE SCIENCES (2015)

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Article Immunology

Increased resistin may suppress reactive oxygen species production and inflammasome activation in type 2 diabetic patients with pulmonary tuberculosis infection

Wen-Cheng Chao et al.

MICROBES AND INFECTION (2015)

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Article Oncology

High glucose promotes gastric cancer chemoresistance in vivo and in vitro

Wei Zhao et al.

MOLECULAR MEDICINE REPORTS (2015)

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Review Cell Biology

Role of the Tumor Microenvironment in Breast Cancer

Savas D. Soysal et al.

PATHOBIOLOGY (2015)

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Article Multidisciplinary Sciences

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Minh Thai et al.

NATURE COMMUNICATIONS (2015)

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Article Endocrinology & Metabolism

High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy

Lu Wang et al.

DIABETOLOGY & METABOLIC SYNDROME (2015)

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Review Oncology

Molecular pathology of emerging coronavirus infections

Lisa E. Gralinski et al.

JOURNAL OF PATHOLOGY (2015)

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Article Virology

Dengue Virus Induces and Requires Glycolysis for Optimal Replication

Krystal A. Fontaine et al.

JOURNAL OF VIROLOGY (2015)

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Review Biochemistry & Molecular Biology

Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

Kerstin Nowotny et al.

BIOMOLECULES (2015)

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Review Biochemistry & Molecular Biology

The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer

Martha E. Kidd et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

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Article Cell Biology

Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication

Minh Thai et al.

CELL METABOLISM (2014)

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Article Endocrinology & Metabolism

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Andre Kleinridders et al.

DIABETES (2014)

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Article Biochemistry & Molecular Biology

High Glucose Modulates Antiproliferative Effect and Cytotoxicity of 5-Fluorouracil in Human Colon Cancer Cells

Yi-Shing Ma et al.

DNA AND CELL BIOLOGY (2014)

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Review Endocrinology & Metabolism

A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose

Custodia Garcia-Jimenez et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2014)

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Review Cell Biology

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

Maria Muriach et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

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Article Multidisciplinary Sciences

Modeling of Hypo/Hyperglycemia and Their Impact on Breast Cancer Progression Related Molecules

Sirin A. I. Adham et al.

PLOS ONE (2014)

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Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

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Review Biotechnology & Applied Microbiology

Hyperglycemia, a Neglected Factor during Cancer Progression

Wanxing Duan et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Immunology

Macrophage cytokines: involvement in immunity and infectious diseases

Guillermo Arango Duque et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Endocrinology & Metabolism

Hyperglycemia as a Risk Factor for Cancer Progression

Tae Young Ryu et al.

DIABETES & METABOLISM JOURNAL (2014)

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Article Biochemistry & Molecular Biology

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Alfred Csibi et al.

CELL (2013)

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Review Biochemistry & Molecular Biology

The SLC2 (GLUT) family of membrane transporters

Mike Mueckler et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

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Article Multidisciplinary Sciences

Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes

Jeannig Berrou et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection

Sarah L. Grady et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Biochemistry & Molecular Biology

Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation

Yeon-Sook Choi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

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Article Biochemistry & Molecular Biology

Roles of p38 MAPKs in invasion and metastasis

Ivan del Barco Barrantes et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2012)

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Article Immunology

High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes

Yolanda Gonzalez et al.

BMC IMMUNOLOGY (2012)

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Review Endocrinology & Metabolism

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

J. A. Johnson et al.

DIABETOLOGIA (2012)

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Review Oncology

Enhanced Radiosensitivity and Chemosensitivity of Breast Cancer Cells by 2-Deoxy-D-Glucose in Combination Therapy

Fahimeh Aghaee et al.

JOURNAL OF BREAST CANCER (2012)

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Article Immunology

IL-17 and TNF-α Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

Gabriel K. Griffin et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Oncology

High expression of heme oxygenase-1 is associated with tumor invasiveness and poor clinical outcome in non-small cell lung cancer patients

Jong-Rung Tsai et al.

CELLULAR ONCOLOGY (2012)

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Review Biochemistry & Molecular Biology

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

Joan M. Cook-Mills et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

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Article Immunology

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

Humberto M. Garay-Malpartida et al.

BMC IMMUNOLOGY (2011)

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Article Oncology

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation

K. Masur et al.

BRITISH JOURNAL OF CANCER (2011)

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Review Oncology

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

Ravi K. Amaravadi et al.

CLINICAL CANCER RESEARCH (2011)

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Article Endocrinology & Metabolism

Kidney: Its impact on glucose homeostasis and hormonal regulation

Asimina Mitrakou

DIABETES RESEARCH AND CLINICAL PRACTICE (2011)

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Article Multidisciplinary Sciences

High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR

Liang Han et al.

PLOS ONE (2011)

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Article Oncology

Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms

Yi Liu et al.

CANCER LETTERS (2010)

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Review Biochemistry & Molecular Biology

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kai Kessenbrock et al.

CELL (2010)

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Article Virology

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

Jeremy W. Chambers et al.

JOURNAL OF VIROLOGY (2010)

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Article Pharmacology & Pharmacy

A crucial role for TNF-α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

S. M. Vieira et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

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Article Gastroenterology & Hepatology

Proteomics Analysis of Mitochondrial Proteins Reveals Overexpression of a Mitochondrial Protein Chaperon, Prohibitin, in Cells Expressing Hepatitis C Virus Core Protein

Takeya Tsutsumi et al.

HEPATOLOGY (2009)

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Article Endocrinology & Metabolism

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes Mechanism of Activation

Mohan R. Dasu et al.

DIABETES (2008)

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Article Immunology

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

Assam El-Osta et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Article Medicine, Research & Experimental

2-Deoxy-D-glucose as a potential drug against fusogenic viruses including HIV

George E. Parris

MEDICAL HYPOTHESES (2008)

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Article Endocrinology & Metabolism

Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species

Sandra Amaral et al.

CURRENT DIABETES REVIEWS (2008)

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Review Biophysics

The Warburg effect and its cancer therapeutic implications

Zhao Chen et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)

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Article Cardiac & Cardiovascular Systems

Selective Rac-1 inhibition protects from diabetes-induced vascular injury

C Vecchione et al.

CIRCULATION RESEARCH (2006)

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Article Biochemistry & Molecular Biology

Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production

M Korenaga et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Review Cell Biology

Matrix metalloproteinases and angiogenesis

JE Rundhaug

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2005)

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Article Anesthesiology

Physiology of the endothelium

HF Galley et al.

BRITISH JOURNAL OF ANAESTHESIA (2004)

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Review Physiology

Role of monocytes in atherogenesis

B Osterud et al.

PHYSIOLOGICAL REVIEWS (2003)

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Article Oncology

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

RL Aft et al.

BRITISH JOURNAL OF CANCER (2002)

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Article Endocrinology & Metabolism

Effect of acute hyperglycemia on insulin secretion in humans

E Toschi et al.

DIABETES (2002)

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Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

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