4.7 Article

Neferine ameliorates hypertensive vascular remodeling modulating multiple signaling pathways in spontaneously hypertensive rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway

Yang Gu et al.

Summary: This study investigates the function and mechanism of RACGAP1 in HCC through analysis and experiments. The findings show that RACGAP1 is up-regulated in HCC and is an independent prognostic risk factor for HCC patients. RACGAP1 promotes the proliferation, invasion, and metastasis of HCC through various signaling pathways, and its transcription is regulated by GABPA.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Article Plant Sciences

Srolo Bzhtang reduces inflammation and vascular remodeling via suppression of the MAPK/NF-ΚB signaling pathway in rats with pulmonary arterial hypertension

Tingting Chen et al.

Summary: This study aimed to investigate the role of SBT in attenuating pulmonary arterial pressure and vascular remodeling caused by MCT and hypoxia. The study found that SBT reduces pulmonary arterial pressure, vascular remodeling, and levels of inflammatory cytokines in rats. Furthermore, SBT significantly suppresses the MAPK/NF-Kappa B signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Medicine, Research & Experimental

Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway

Ying Cheng et al.

Summary: QDG treatment in Ang II-induced hypertension mice model reduced blood pressure and improved cardiac function, attenuating cardiac hypertrophy and apoptosis. In cellular experiments, QDG partially reversed the expression of hypertrophy markers and apoptosis-related proteins induced by Ang II.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Medicine, Research & Experimental

Baicalin attenuates angiotensin II-induced blood pressure elevation and modulates MLCK/p-MLC signaling pathway

Huixin Liu et al.

Summary: Baicalin from Scutellaria baicalensis Georgi has been shown to have therapeutic effects on anti-hypertension through regulating vascular contraction, calcium signaling pathway and cell proliferation. The study revealed that Baicalin treatment can reduce blood pressure, alleviate vascular wall thickening, and inhibit pathological changes induced by Ang II.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Anti-Allergic and Anti-Inflammatory Effects of Neferine on RBL-2H3 Cells

Kuan-Ming Chiu et al.

Summary: Neferine has anti-allergic and anti-inflammatory effects on mast cells by inhibiting degranulation and cytokine expression, decreasing intracellular calcium levels, and reducing the phosphorylation of the MAPK/NF-kappa B pathway. In vivo studies demonstrate that neferine improves dermatitis appearance, mast cell infiltration, and restores barrier protein expression. Neferine also reduces scratching behavior induced by compound 48/80, suggesting its potential as a natural product for skin allergy and inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway

Man Xu et al.

Summary: The study found that cilomilast has a protective effect against renal tubulointerstitial fibrosis in chronic kidney diseases, possibly through inhibition of the TGF-beta 1-Smad2/3 signaling pathway.

FRONTIERS IN MEDICINE (2021)

Article Medicine, Research & Experimental

Qingda granule attenuates cardiac fibrosis via suppression of the TGF-β1/ Smad2/3 signaling pathway in vitro and in vivo

Xiaoping Chen et al.

Summary: Our studies suggest that QDG reduces blood pressure and cardiac fibrosis, protects cardiac function, and suppresses TGF-β1/Smad2/3 signaling in vivo and in vitro.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cardiac & Cardiovascular Systems

Ventromedial Hypothalamus Activation Aggravates Hypertension Myocardial Remodeling Through the Sympathetic Nervous System

Yuyang Zhou et al.

Summary: The study found that activation of VMH increased systolic blood pressure and exacerbated cardiac remodeling in 2K1C hypertension rats, possibly by regulating fatty acid metabolism through the HIF-1α/PPARα/CPT-1 signaling pathway.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Notch2 suppression mimicking changes in human pulmonary hypertension modulates Notch1 and promotes endothelial cell proliferation

Sanghamitra Sahoo et al.

Summary: The study reveals a crucial role for Notch2 in maintaining lung vascular endothelial cell quiescence and in PAH, with loss of Notch2 activating Notch1 and inducing proliferation and apoptosis resistance in human pulmonary artery endothelial cells. PAH patients exhibit reduced levels of endothelial Notch2 in pulmonary arteries, suggesting Notch2 as a fundamental driver of PAH pathogenesis.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Review Medicine, General & Internal

Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence

Hong-Mi Choi et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2020)

Article Critical Care Medicine

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

Zhiyu Dai et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

Status of Hypertension in China Results From the China Hypertension Survey, 2012-2015

Zengwu Wang et al.

CIRCULATION (2018)

Article Hematology

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Isola A. M. Brown et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Integrative & Complementary Medicine

Anti-Fibrotic Effects of Neferine on Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice

Mo-Si Chen et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2015)

Article Medicine, General & Internal

Hypertension

Neil R. Poulter et al.

LANCET (2015)

Review Pharmacology & Pharmacy

The critical role of Akt in cardiovascular function

Prasanna Abeyrathna et al.

VASCULAR PHARMACOLOGY (2015)

Review Peripheral Vascular Disease

Arterial Stiffness and Hypertension Chicken or Egg?

Gary F. Mitchell

HYPERTENSION (2014)

Article Cell Biology

15-LO/15-HETE Mediated Vascular Adventitia Fibrosis via p38 MAPK-Dependent TGF-β

Li Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2014)

Review Medicine, Research & Experimental

Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis

Markella Ponticos et al.

JOURNAL OF BIOMEDICAL RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

Renin-Angiotensin Blockade Combined With Natriuretic Peptide System Augmentation Novel Therapeutic Concepts to Combat Heart Failure

Thomas G. von Lueder et al.

CIRCULATION-HEART FAILURE (2013)

Review Pharmacology & Pharmacy

Small Artery Remodelling in Hypertension

Michael J. Mulvany

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

Editorial Material Peripheral Vascular Disease

Arterial Stiffness as Surrogate End Point Needed Clinical Trials

Stephane Laurent et al.

HYPERTENSION (2012)

Editorial Material Peripheral Vascular Disease

Vascular Remodeling in Hypertension Mechanisms and Treatment

Ernesto L. Schiffrin

HYPERTENSION (2012)

Article Hematology

Myofibroblast-Mediated Adventitial Remodeling An Underestimated Player in Arterial Pathology

Matteo Coen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Article Chemistry, Medicinal

Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera

Atsuko Itoh et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2011)

Review Biotechnology & Applied Microbiology

Sequencing technologies and genome sequencing

Chandra Shekhar Pareek et al.

JOURNAL OF APPLIED GENETICS (2011)

Article Pharmacology & Pharmacy

Effects of exogenous urotensin II on vascular remodelling after balloon injury

Li-Fang Zhang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2010)

Article Pharmacology & Pharmacy

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

Libo Zhao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

Review Cardiac & Cardiovascular Systems

Extracellular matrix alterations in hypertensive vascular remodeling

Catherine A. Lemarie et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

Article Plant Sciences

Neferine enhances insulin sensitivity in insulin resistant rats

Yang Pan et al.

JOURNAL OF ETHNOPHARMACOLOGY (2009)

Review Engineering, Biomedical

Adaptation and remodeling of vascular wall; biomechanical response to hypertension

Kozaburo Hayashi et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2009)

Article Pharmacology & Pharmacy

Pharmacokinetics and metabolism of neferine in rats after a single oral administration

Ying Huang et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2007)

Article Peripheral Vascular Disease

Small artery remodeling in hypertension and diabetes

Damiano Rizzoni et al.

CURRENT HYPERTENSION REPORTS (2006)

Article Medicine, General & Internal

Global burden of hypertension: analysis of worldwide data

PM Kearney et al.

LANCET (2005)

Review Biochemistry & Molecular Biology

TGF-β signaling and the fibrotic response

A Leask et al.

FASEB JOURNAL (2004)

Article Cardiac & Cardiovascular Systems

Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca2+ channels

N Macrez et al.

CIRCULATION RESEARCH (2001)

Article Peripheral Vascular Disease

Vascular remodeling in hypertension - Roles of apoptosis, inflammation, and fibrosis

HD Intengan et al.

HYPERTENSION (2001)