Gongolarones as antiamoeboid chemical scaffold

Review Biochemistry & Molecular Biology

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Senhua Chen et al.

Summary: This review summarizes the discoveries of new metabolites isolated from mangrove-associated fungi over the past thirty years, focusing on the bioactivity and unique chemical diversity of these natural products.

NATURAL PRODUCT REPORTS (2022)

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Review Chemistry, Medicinal

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

Usman Ahmed et al.

Summary: Acanthamoeba is a genus of free-living amoebae that often causes sight-threatening keratitis and fatal encephalitis. Developing effective treatments for Acanthamoeba infections remains challenging, highlighting the need for new approaches to eliminate such rare but serious infections.

MEDICINAL RESEARCH REVIEWS (2022)

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Review Chemistry, Medicinal

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

Hossam S. El-Beltagi et al.

Summary: Seaweeds have long been recognized as a valuable source of bioactive compounds, with potential applications in nutrition, pharmacology, industry, and biochemistry, as well as positive effects on human health.

MARINE DRUGS (2022)

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Article Biochemistry & Molecular Biology

Squamins C-F, four cyclopeptides from the seeds of Annona globiflora

Javier Sosa-Rueda et al.

Summary: Four cyclic octapeptides, named squamins C-F, were isolated from the seeds of Annona globiflora Schltdl. These compounds showed cytotoxic activity against human prostate cancer and cervical carcinoma cell lines, indicating the potential of A. globiflora as a source of bioactive molecules.

PHYTOCHEMISTRY (2022)

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Article Chemistry, Medicinal

May the Force (Field) Be with You: On the Importance of Conformational Searches in the Prediction of NMR Chemical Shifts

Cristina Cuadrado et al.

Summary: This study assessed the impact of force field selection, geometry, and energy cutoffs in NMR data prediction for structure elucidation. A new method called mix-J-DP4 was proposed based on the conclusions, which showed a remarkable increase in the confidence level of complex stereochemical assignments with a modest increment in computational cost.

MARINE DRUGS (2022)

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Article Pharmacology & Pharmacy

Pitavastatin loaded nanoparticles: A suitable ophthalmic treatment for Acanthamoeba Keratitis inducing cell death and autophagy in Acanthamoeba polyphaga

Ines Sifaoui et al.

Summary: The present study aimed to develop Pitavastatin loaded nanoparticles suitable for ophthalmic administration and designed for the management of Acanthamoeba Keratitis. The nanoparticles obtained through a nanoprecipitation-solvent displacement method showed good amoebicidal activity and could solve the issue of poor aqueous solubility of Pitavastatin.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Food Science & Technology

Undervalued Atlantic brown seaweed species (Cystoseira abies-marinaandZonaria tournefortii): influence of treatment on their nutritional and bioactive potential and bioaccessibility

I. Fonseca et al.

Summary: The study evaluated the composition, bioactivity, and bioaccessibility of the brown seaweed species Cystoseira abies-marina and Zonaria tournefortii. C. abies-marina was richer in PUFA, while Z. tournefortii was richer in SFA. Rehydration led to a reduction in elemental concentration in most instances.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2021)

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Article Chemistry, Organic

Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate Prorocentrum hoffmannianum

Humberto J. Dominguez et al.

Summary: The research determined the relative configuration of Prorocentroic acid and its effects on murine cortical neurons. Long-term exposure to subtoxic concentrations caused significant reorganization of neuronal signaling, potentially through the activation of plasticity processes.

ORGANIC LETTERS (2021)

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Article Chemistry, Organic

Are Computational Methods Useful for Structure Elucidation of Large and Flexible Molecules? Belizentrin as a Case Study

Antonio Hernandez Daranas et al.

Summary: This report introduces a method that combines quantum mechanical NMR calculations with conformer selection to solve the structure of large, complex, and highly flexible molecules.

ORGANIC LETTERS (2021)

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Article Parasitology

Antiamoeboid activity of squamins C-F, cyclooctapeptides from Annona globifora

Ruben L. Rodriguez-Exposito et al.

Summary: The study found that the cyclooctapeptides squamins C-F from Annona globiflora exhibit anti-amoeboid activity against Acanthamoeba, especially sensitive to A. castellanii Neff. These peptides can induce programmed cell death in Acanthamoeba, causing mitochondrial damage and increased production of reactive oxygen species (ROS), but they have no cytotoxic effects on murine macrophages.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2021)

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Article Parasitology

Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis

Olfa Chiboub et al.

Summary: The study found that three isolated diterpenes could induce apoptosis-like cell death in tested parasites, inhibiting L. amazonensis and T. cruzi. These results support further investigation on these compounds as potential drug candidates.

PARASITES & VECTORS (2021)

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Review Biochemistry & Molecular Biology

Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications

Ana C. S. Verissimo et al.

Summary: Marine organisms have been found to produce bioactive compounds with anticancer properties, particularly from securamines and sterols families. In the last few years, compounds isolated from marine sources have been studied for their cytotoxic/antiproliferative activity in different cell lines, showing promising results. These findings suggest the potential for new therapeutic agents derived from marine sources in the treatment of cancer.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

Haresh S. Kalasariya et al.

Summary: Seaweeds are recognized as one of the richest sources of biologically active ingredients with powerful activities, making them a promising alternative to synthetic cosmetics. With numerous beneficial skin activities, such as antioxidant, anti-aging, and antiviral properties, seaweed-based products are increasingly popular in the cosmetic industry as a safe and effective option for consumers.

MOLECULES (2021)

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Review Ophthalmology

Acanthamoeba keratitis: a review of biology, pathophysiology and epidemiology

Ana Gomes de Lacerda et al.

Summary: Acanthamoeba keratitis is a widespread infection caused by a unicellular protozoan that mainly affects contact lens wearers and is linked to corneal trauma as well. It is essential to deepen the understanding of risk factors, focus on prevention strategies, and enhance the efficacy of disinfection systems to minimize the risk of infection. Additionally, there is a need for the development of effective diagnostic methods and treatments for this type of corneal infection in the near future.

OPHTHALMIC AND PHYSIOLOGICAL OPTICS (2021)

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Article Plant Sciences

Seasonality in the canopy structure of the endangered brown macroalga Cystoseira abies-marina at Gran Canaria Island (Canary Islands, eastern Atlantic)

Jose Valdazo et al.

EUROPEAN JOURNAL OF PHYCOLOGY (2020)

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Article Chemistry, Organic

Quantum Mechanical-NMR-Aided Configuration and Conformation of Two Unreported Macrocycles Isolated from the Soft Coral Lobophytum sp.: Energy Calculations versus Coupling Constants

Song-Wei Li et al.

ORGANIC LETTERS (2020)

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Review Cell Biology

Autophagy as a modulator of cell death machinery

Masayuki Noguchi et al.

CELL DEATH & DISEASE (2020)

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Article Chemistry, Applied

Report of in vitro antileishmanial properties of Iberian macroalgae

Carolina Bruno de Sousa et al.

NATURAL PRODUCT RESEARCH (2019)

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Article Nursing

Emerging Infectious Diseases

Donna Behler McArthur

NURSING CLINICS OF NORTH AMERICA (2019)

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Article Chemistry, Organic

Combining the Power of J Coupling and DP4 Analysis on Stereochemical Assignments: The J-DP4 Methods

Nicolas Grimblat et al.

ORGANIC LETTERS (2019)

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Article Plant Sciences

Diversity of Cystoseira sensu lato (Fucales, Phaeophyceae) in the eastern Atlantic and Mediterranean based on morphological and DNA evidence, including Carpodesmia gen. emend. and Treptacantha gen. emend.

Sharay Orellana et al.

EUROPEAN JOURNAL OF PHYCOLOGY (2019)

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Article Chemistry, Medicinal

Evaluation of Oxasqualenoids from the Red Alga Laurencia viridis against Acanthamoeba

Jacob Lorenzo-Morales et al.

MARINE DRUGS (2019)

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Review Microbiology

Free-living amoebae and squatters in the wild: ecological and molecular features

Ascel Samba-Louaka et al.

FEMS MICROBIOLOGY REVIEWS (2019)

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Article Microbiology

Apoptosis of Acanthamoeba castellanii Trophozoites Induced by Oleic Acid

Duo Wu et al.

JOURNAL OF EUKARYOTIC MICROBIOLOGY (2018)

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Review Parasitology

Combating Acanthamoeba spp. cysts: what are the options?

Ayaz Anwar et al.

PARASITES & VECTORS (2018)

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Review Cell Biology

Life, death and autophagy

Johnna Doherty et al.

NATURE CELL BIOLOGY (2018)

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Article Parasitology

Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata

Carolina Bruno de Sousa et al.

EXPERIMENTAL PARASITOLOGY (2017)

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Article Chemistry, Inorganic & Nuclear

Cystoseira algae (Fucaceae): update on their chemical entities and biological activities

Carolina Bruno de Sousa et al.

TETRAHEDRON-ASYMMETRY (2017)

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Review Biotechnology & Applied Microbiology

Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges

Nicholas Israel Nii-Trebi

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Plant Sciences

Cystoseira usneoides: A Brown Alga Rich in Antioxidant and Anti-inflammatory Meroditerpenoids

Carolina de los Reyes et al.

JOURNAL OF NATURAL PRODUCTS (2016)

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Article Chemistry, Organic

Beyond DP4: an Improved Probability for the Stereochemical Assignment of Isomeric Compounds using Quantum Chemical Calculations of NMR Shifts

Nicolas Grimblat et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

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Review Parasitology

An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment

Jacob Lorenzo-Morales et al.

PARASITE (2015)

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Article Public, Environmental & Occupational Health

Presence of potentially pathogenic free-living amoebae strains from well water samples in Guinea-Bissau

Rocio A. Baquero et al.

PATHOGENS AND GLOBAL HEALTH (2014)

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Article Parasitology

Acanthamoeba royreba: Morphological features and in vitro cytopathic effect

Arturo Gonzalez-Robles et al.

EXPERIMENTAL PARASITOLOGY (2013)

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Review Chemistry, Medicinal

Di- and Sesquiterpenoids from Cystoseira Genus: Structure, Intra-molecular Transformations and Biological Activity

Vera Gouveia et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2013)

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Article Chemistry, Medicinal

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Jasmine Spavieri et al.

MARINE DRUGS (2013)

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Article Plant Sciences

Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina

Vera L. M. Gouveia et al.

PHYTOCHEMISTRY LETTERS (2013)

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Review Parasitology

Biology and pathogenesis of Acanthamoeba

Ruqaiyyah Siddiqui et al.

PARASITES & VECTORS (2012)

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Article Chemistry, Multidisciplinary

Assigning Stereochemistry to Single Diastereoisomers by GIAO NMR Calculation: The DP4 Probability

Steven G. Smith et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Article Chemistry, Medicinal

Antimycobacterial, Antiprotozoal and Cytotoxic Potential of Twenty-one Brown Algae (Phaeophyceae) from British and Irish Waters

Jasmine Spavieri et al.

PHYTOTHERAPY RESEARCH (2010)

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Article Chemistry, Inorganic & Nuclear

Synthesis and absolute configuration of (S)-(+)-chichimol ketone: the defensive secretion of walking stick Agathemera elegans

Marlene Espinoza-Moraga et al.

TETRAHEDRON-ASYMMETRY (2009)

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Article Microbiology

The potential pathogenicity of chlorhexidine-sensitive Acanthamoeba strains isolated from contact lens cases from asymptomatic individuals in Tenerife, Canary Islands, Spain

Carmen M. Martin-Navarro et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2008)

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Review Immunology

Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea

Govinda S. Visvesvara et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2007)

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Article Microbiology

Ultrastructural study of encystation and excystation in Acanthamoeba castellanii

B Chávez-Munguía et al.

JOURNAL OF EUKARYOTIC MICROBIOLOGY (2005)

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Article Microbiology

Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba

J McBride et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2005)

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Gongolarones as antiamoeboid chemical scaffold

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