An automatic method for microscopic diagnosis of diseases based on URCNN

Anthrax is a rare but dangerous disease for humans. A common way to diagnose this disease is the microscopic examination of slides containing tissue samples of patients. This paper aims to develop a reliable system in histopathological image analysis for the diagnosis of tissue diseases, metastasis, patient prognosis, etc. Automatic diagnosis of anthrax is investigated via the detection and segmentation of Bacillus anthracis bacteria and major immune system cells. Most recent models for instance segmentation are based on Mask-RCNN. It has an acceptable performance in most cases, but due to the challenges in the field of microscopic images, it fails to accurately detect and segment some of the important objects. Here, we have improved the performance of Mask-RCNN by making some modifications as follows: (1) A U-shaped structure is used as the mask branch in the head of Mask-RCNN that takes the advantage of combining multi-scale feature maps, (2) An enhanced FPN structure is proposed, which takes advantage of the squeeze and excitation-residual blocks and squeeze and excitation -inception blocks, (3) A hybrid weighted loss function composed of LBCE, LDiceandLIoU is proposed to update the weights and (4) Finally, a dropout layer is added after each FC layer in the classifier structure of the head Mask-RCNN architecture to improve the generalization power of the model. Experimental results show that the pro-posed model outperforms the state-of-the-art architectures and is a reliable system for the automatic diagnosis of anthrax.

Automated summary

This paper aims to develop a reliable system for the automatic diagnosis of anthrax by improving the performance of Mask-RCNN. By incorporating a U-shaped structure, an enhanced FPN structure, a hybrid weighted loss function, and a dropout layer, the proposed model outperforms state-of-the-art architectures.