期刊
BIOMEDICAL MATERIALS
卷 18, 期 2, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1748-605X/acb4cd
关键词
magnesium phosphate bone cement; clay minerals; compressive strength; bioactivity
To address the poor mechanical strength and bioactivity of magnesium phosphate bone cements (MPCs), clay minerals were incorporated to fabricate MPCs composite. The resulting MPCs composite showed appropriate setting time, high mechanical strength, and good thermal stability. In particular, the MPCs composite containing 3.0 wt.% of sepiolite exhibited the highest compressive strength and the best thermal stability.
The poor mechanical strength and bioactivity of magnesium phosphate bone cements (MPCs) are the vital defects for bone reconstruction. Clay minerals have been widely used in biomedical field due to the good reinforcing property and cytocompatibility. Here, laponite, sepiolite or halloysite were incorporated to fabricate MPCs composite, and the composition, microstructure, setting time, compressive strength, thermal stability, degradation performance, in vitro bioactivity and cell viability of MPCs composite were investigated. The results suggested that the MPCs composite possessed appropriate setting time, high mechanical strength and good thermal stability. By contrast, MPCs composite containing 3.0 wt.% of sepiolite presented the highest compressive strength (33.45 +/- 2.87 MPa) and the best thermal stability. The degradation ratio of MPCs composite was slightly slower than that of MPCs, and varied in simulated body fluid and phosphate buffer solution. Therefore, the obtained MPCs composite with excellent bioactivity and cell viability was expected to meet the clinical requirements for filling bone defect.
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