期刊
BIOMATERIALS
卷 292, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2022.121917
关键词
Glioma; Noninflammatory photothermal therapy; Zirconium carbide; ROS scavenging; CT imaging
Liquid exfoliation was used to create ultrasmall zirconium carbide nanodots (NDs) as noninflammatory/anti-inflammatory photosensitizers for photothermal therapy (PTT) of glioma. The ultrasmall ZrC NDs showed excellent photothermal stability and biocompatibility, effectively ablating glioma at low concentrations and inhibiting tumor migration and proliferation. Furthermore, the ultrasmall ZrC NDs suppressed the inflammatory response to PTT by exhibiting excellent ROS-scavenging ability.
Photothermal therapy (PTT), like other clinical translational tumor ablation techniques, requires a temperature increase above 50 degrees C to cause necrosis and death of tumor cells. Although the tumor can be eliminated rapidly by PTT, the inflammatory response is triggered by the large amounts of released reactive oxygen species (ROS). Therefore, liquid exfoliation was used to create ultrasmall zirconium carbide nanodots (NDs) with an average diameter of approximately 4.5 nm as noninflammatory/anti-inflammatory photosensitizers for PTT of glioma. Ultrasmall ZrC NDs showed excellent photothermal stability and biocompatibility but no obvious toxicity. Moreover, the ultrasmall ZrC NDs effectively ablated glioma at relatively low concentrations and inhibited tumor migration and proliferation in vitro and in vivo. Furthermore, the excellent ROS-scavenging ability of ultrasmall ZrC NDs suppressed the inflammatory response to PTT. Intriguingly, we found that ZrC had the capability of performing CT imaging. We demonstrated that the ultrasmall ZrC NDs created in this study could effectively and safely treat glioma without inflammation.
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