☆ 4.3 Review

A biochemical view on the septins, a less known component of the cytoskeleton

BIOLOGICAL CHEMISTRY (2023)

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Review Cell Biology

Phosphoregulation of the septin cytoskeleton in neuronal development and disease

Bailey Werner et al.

Summary: Septins, highly conserved GTP-binding proteins, play important roles in cellular organization, intracellular transport, and cytokinesis. The phosphorylation of septins by kinases regulates various aspects of their function, localization, and dynamics. Septins are enriched in the nervous system and abnormal phosphorylation is implicated in neurological disorders.

CYTOSKELETON (2023)

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Review Cell Biology

Septins From Protists to People

Brent Shuman et al.

Summary: Septin GTPases form nonpolar heteropolymers that are crucial for cytokinesis and other cellular processes. Members of different septin groups interact to form core septins, while group 5 septins do not participate in canonical heteropolymers. Understanding the relationships of septins across kingdoms can provide new insights into their functions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Pathology

Novel Functions of the Septin Cytoskeleton Shaping Up Tissue Inflammation and Fibrosis

Andrei I. Ivanov et al.

Summary: Chronic inflammatory diseases cause significant changes in tissue homeostasis, with remodeling of the intracellular cytoskeleton being critical for cell activation in inflamed and fibrotic tissues. This article discusses the role of the septin cytoskeleton in inflammation and potential therapeutic interventions.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Cell Biology

Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties

Forooz Soroor et al.

Summary: Septins are conserved GTP-binding cytoskeletal proteins that can polymerize into different forms of hexamers and octamers. These structures are able to polymerize individually and surprisingly, with each other. The organization of these complexes in cells differs from the original prediction, suggesting that their properties may be more conserved across different organisms.

MOLECULAR BIOLOGY OF THE CELL (2021)

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Article Cell Biology

Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling

Benjamin L. Woods et al.

Summary: The study shows that the nonessential fungal septin, Shs1, has an amphipathic helix (AH) domain capable of recognizing membrane curvature. In a septin mutant strain lacking a fully functional Cdc12 AH domain, the C-terminal extension of Shs1, containing an AH domain, becomes essential. This suggests that septin AH domains have multiple distinct functions and that bundling and membrane binding may be coordinately controlled.

MOLECULAR BIOLOGY OF THE CELL (2021)

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Article Cell Biology

Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis

Han-Yu Wang et al.

Summary: The study reveals that PKA phosphorylates SEPT7, disrupting septin filament dynamics and ciliogenesis, leading to a novel understanding of the biological function of SEPT7 phosphorylation in cell growth and migration.

CELLS (2021)

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Review Cell Biology

The Structural Biology of Septins and Their Filaments: An Update

Italo A. Cavini et al.

Summary: Understanding the three-dimensional structures of molecular components in biochemical systems, such as septins, is crucial for unraveling their mechanistic functions. Recent advances have provided more detailed insights into the structural basis of higher-order septin assemblies, although further research is needed to fully understand their physiological roles and interactions with cellular components.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Orientational Ambiguity in Septin Coiled Coils and its Structural Basis

Diego A. Leonardo et al.

Summary: Septins are composed of different paralogues that must be correctly assembled into functional filaments important for essential cellular events. Most septins possess C-terminal domains capable of forming coils, and the study reveals dimeric structures with both parallel and antiparallel arrangements. Both arrangements are energetically accessible, with antiparallel structures presenting a mixed coiled-coil interface.

JOURNAL OF MOLECULAR BIOLOGY (2021)

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Article Cell Biology

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

Francois Iv et al.

Summary: This study successfully isolated recombinant human septin octamers containing different SEPT9 isoforms for the first time, confirming their octameric nature in solution. Reconstitution studies showed that octamers with either long or short SEPT9 isoforms can form filament assemblies and directly bind and cross-link actin filaments, suggesting that septin-decorated actin structures in cells may reflect direct actin-septin interactions. These recombinant SEPT9-containing octamers will enable the design of cell-free assays to study the complex interactions of septins with cell membranes and the actin and microtubule cytoskeleton.

JOURNAL OF CELL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

An atomic model for the human septin hexamer by cryo-EM

Deborah C. Mendonca et al.

Summary: Human septins must form hetero-oligomeric rod-like particles to create functional filaments, and a cryo-electron microscopy structure has revealed the internal cavity and interactions between component subunits within the hexameric rod. The elongated particle exhibits bending at the center where SEPT7 forms a homodimeric interface, which is likely related to the ability of septin filaments to recognize and induce membrane curvature.

JOURNAL OF MOLECULAR BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface

Danielle Karoline Silva do Vale Castro et al.

IUCRJ (2020)

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Article Biochemistry & Molecular Biology

Molecular Recognition at Septin Interfaces: The Switches Hold the Key

Higor Vinicius Dias Rosa et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Article Biology

On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment

Liam M. Longo et al.

ELIFE (2020)

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Review Cell Biology

Septins: Active GTPases or just GTP-binding proteins?

Megha Abbey et al.

CYTOSKELETON (2019)

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Article Cell Biology

Dissecting the nucleotide binding properties of the septins from S. cerevisiae

Julian David Baur et al.

CYTOSKELETON (2019)

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Article Multidisciplinary Sciences

Membrane reshaping by micrometric curvature sensitive septin filaments

Alexandre Beber et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases

Ana R. Calixto et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Biochemistry & Molecular Biology

Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions

Jenna Marcus et al.

ONCOGENE (2019)

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Article Evolutionary Biology

Diversity of opisthokont septin proteins reveals structural constraints and conserved motifs

Benjamin Auxier et al.

BMC EVOLUTIONARY BIOLOGY (2019)

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Article Cell Biology

Control of septin filament flexibility and bundling by subunit composition and nucleotide interactions

Anum Khan et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

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Article Biochemistry & Molecular Biology

Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii

Andressa P. A. Pinto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Cell Biology

SUMOylation of human septins is critical for septin filament bundling and cytokinesis

David Ribet et al.

JOURNAL OF CELL BIOLOGY (2017)

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Article Genetics & Heredity

SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility

Yi-Ru Shen et al.

PLOS GENETICS (2017)

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Article Biology

The step-wise pathway of septin hetero-octamer assembly in budding yeast

Andrew Weems et al.

ELIFE (2017)

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Article Cell Biology

Assembly, molecular organization, and membrane-binding properties of development-specific septins

Galo Garcia et al.

JOURNAL OF CELL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae

Anton Brausemann et al.

JOURNAL OF STRUCTURAL BIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Modeling the mechanisms of biological GTP hydrolysis

Alexandra T. P. Carvalho et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)

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Article Genetics & Heredity

The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae

Gregory C. Finnigan et al.

GENETICS (2015)

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Article Genetics & Heredity

Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae

Gregory C. Finnigan et al.

GENETICS (2015)

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Article Biochemistry & Molecular Biology

Septin Dynamics Are Essential for Exocytosis

Elmira Tokhtaeva et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Biochemistry & Molecular Biology

Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity

Clayton Smith et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

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Article Cell Biology

Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast

Courtney R. Johnson et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

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Article Genetics & Heredity

The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae

Gregory C. Finnigan et al.

GENETICS (2015)

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Article Genetics & Heredity

Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae

Gregory C. Finnigan et al.

GENETICS (2015)

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Article Biochemistry & Molecular Biology

Human septin isoforms and the GDP-GTP cycle

Eldar Zent et al.

BIOLOGICAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Septin functions in organ system physiology and pathology

Lee Dolat et al.

BIOLOGICAL CHEMISTRY (2014)

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Article Genetics & Heredity

Higher-Order Septin Assembly Is Driven by GTP-Promoted Conformational Changes: Evidence From Unbiased Mutational Analysis in Saccharomyces cerevisiae

Andrew D. Weems et al.

GENETICS (2014)

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Article Biochemistry & Molecular Biology

Crystal Structure of a Schistosoma mansoni Septin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide

Ana E. Zeraik et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Cell Biology

Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles

Manos Mavrakis et al.

NATURE CELL BIOLOGY (2014)

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Article Multidisciplinary Sciences

Distinct Septin Heteropolymers Co-Exist during Multicellular Development in the Filamentous Fungus Aspergillus nidulans

Yainitza Hernandez-Rodriguez et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Architecture and dynamic remodelling of the septin cytoskeleton during the cell cycle

Katy Ong et al.

NATURE COMMUNICATIONS (2014)

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Article Biotechnology & Applied Microbiology

An efficient protocol for the purification and labeling of entire yeast septin rods from E.coli for quantitative in vitro experimentation

Christian Renz et al.

BMC BIOTECHNOLOGY (2013)

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Article Biophysics

The Role of Magnesium for Geometry and Charge in GTP Hydrolysis, Revealed by Quantum Mechanics/Molecular Mechanics Simulations

Till Rudack et al.

BIOPHYSICAL JOURNAL (2012)

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Review Microbiology

Posttranslational modifications and assembly of septin heteropolymers and higher-order structures

Yainitza Hernandez-Rodriguez et al.

CURRENT OPINION IN MICROBIOLOGY (2012)

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Article Genetics & Heredity

Cell Polarization and Cytokinesis in Budding Yeast

Erfei Bi et al.

GENETICS (2012)

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Article Biochemistry & Molecular Biology

Structural and biochemical properties of Sept7, a unique septin required for filament formation

Eldar Zent et al.

BIOLOGICAL CHEMISTRY (2011)

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Article Cell Biology

Subunit-dependent modulation of septin assembly: Budding yeast septin Shs1 promotes ring and gauze formation

Galo Garcia et al.

JOURNAL OF CELL BIOLOGY (2011)

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Article Cell Biology

Microtubules support a disk-like septin arrangement at the plasma membrane of mammalian cells

Mikael E. Sellin et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

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Article Hematology

Deletion of human GP1BB and SEPT5 is associated with Bernard-Soulier syndrome, platelet secretion defect, polymicrogyria, and developmental delay

Ingrid Bartsch et al.

THROMBOSIS AND HAEMOSTASIS (2011)

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Review Cell Biology

Septin structure and function in yeast and beyond

Younghoon Oh et al.

TRENDS IN CELL BIOLOGY (2011)

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Article Cell Biology

Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

Mathew P. Estey et al.

JOURNAL OF CELL BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization

Aurelie Bertin et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

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Article Multidisciplinary Sciences

GTP-induced conformational changes in septins and implications for function

Minhajuddin Sirajuddin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

Role of nucleotide binding in septin-septin interactions and septin localization in Saccharomyces cerevisiae

Satish Nagaraj et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

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Review Cell Biology

The septin family of GTPases: Architecture and dynamics

Christine S. Weirich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Article Multidisciplinary Sciences

Saccharomyces cerevisiae septins:: Supramolecular organization of heterooligomers and the mechanism of filament assembly

Aurelie Bertin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Multidisciplinary Sciences

Structural insight into filament formation by mammalian septins

Minhajuddin Sirajuddin et al.

NATURE (2007)

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Article Evolutionary Biology

Analysis of septins across kingdoms reveals orthology and new motifs

Fangfang Pan et al.

BMC EVOLUTIONARY BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

GTP binding and hydrolysis kinetics of human septin 2

Yi-Wei Huang et al.

FEBS JOURNAL (2006)

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Article Cell Biology

Role of the septin ring in the asymmetric localization of proteins at the mother-bud neck in Saccharomyces cerevisiae

L Kozubowski et al.

MOLECULAR BIOLOGY OF THE CELL (2005)

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Article Biochemistry & Molecular Biology

Nucleotide binding and filament assembly of recombinant yeast septin complexes

M Farkasovsky et al.

BIOLOGICAL CHEMISTRY (2005)

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Article Cell Biology

Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4

M Versele et al.

JOURNAL OF CELL BIOLOGY (2004)

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Article Biochemistry & Molecular Biology

The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides

AM Vrabioiu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Cell Biology

Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae

M Versele et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

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Review Biochemistry & Molecular Biology

Assembly of mammalian septins

M Kinoshita

JOURNAL OF BIOCHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments

PJ Sheffield et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Cell Biology

Mammalian septins nomenclature

IG Macara et al.

MOLECULAR BIOLOGY OF THE CELL (2002)

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Article Biochemistry & Molecular Biology

GTP binding induces filament assembly of a recombinant septin

M Mendoza et al.

CURRENT BIOLOGY (2002)

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Review Multidisciplinary Sciences

Signal transduction - The guanine nucleotide-binding switch in three dimensions

IR Vetter et al.

SCIENCE (2001)

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Article Biochemistry & Molecular Biology

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

BL Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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