期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 37, 页码 9604-9617出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1763-16.2016
关键词
electrical coupling; GABA; interglomerular circuit; intrinsic properties; monosynaptic inhibition; olfactory bulb
资金
- National Institutes of Health [DC005676, DC010915, DC014447]
Sensory processing shapes our perception. In mammals, odor information is encoded by combinatorial activity patterns of olfactory bulb (OB) glomeruli. Glomeruli are richly interconnected by short axon cells (SACs), which form the interglomerular circuit (IGC). It is unclear how the IGC impacts OB output to downstream neural circuits. We combined in vitro and in vivo electrophysiology with optogenetics in mice and found the following: (1) the IGC potently and monosynaptically inhibits the OB output neurons mitral/tufted cells (MTCs) by GABA release from SACs: (2) gap junction-mediated electrical coupling is strong for the SAC -> MTC synapse, but negligible for the SAC -> ETC synapse; (3) brief IGC-mediated inhibition is temporally prolonged by the intrinsic properties of MTCs; and (4) sniff frequency IGC activation in vivo generates persistent MTC inhibition. These findings suggest that the temporal sequence of glomerular activation by sensory input determines which stimulus features are transmitted to downstream olfactory networks and those filtered by lateral inhibition.
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