期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 39, 页码 9977-9989出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1095-16.2016
关键词
biosensors; fluorescence imaging; genetically encoded voltage indicators (GEVI); voltage imaging
资金
- McNair Medical Institute
- Stanford Interdisciplinary Graduate Fellowship
- National Institutes of Health [R01 EY022638, R21 NS081507]
A longstanding goal in neuroscience is to understand how spatiotemporal patterns of neuronal electrical activity underlie brain function, from sensory representations to decision making. An emerging technology for monitoring electrical dynamics, voltage imaging using genetically encoded voltage indicators (GEVIs), couples the power of genetics with the advantages of light. Here, we review the properties that determine indicator performance and applicability, discussing both recent progress and technical limitations. We then consider GEVI applications, highlighting studies that have already deployed GEVIs for biological discovery. We also examine which classes of biological questions GEVIs are primed to address and which ones are beyond their current capabilities. As GEVIs are further developed, weanticipate that they will become more broadly used by the neuroscience community to eavesdrop on brain activity with unprecedented spatiotemporal resolution.
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