期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 44, 页码 11308-11319出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2493-16.2016
关键词
aging; exercise; hearing loss; stria vascularis
资金
- National Institute on Deafness and Communication Disorders-National Institutes of Health (NIH) [R01 DC012552, R01 DC014437, R03 DC011840]
- American Federation for Aging Research [12388]
- Claude D. Pepper Older Americans Independence Centers at the University of Florida (NIH National Institute on Aging Grant) [1 P30 AG028740]
- Japan Society for the Promotion of Science [23228003]
- Grants-in-Aid for Scientific Research [23228003] Funding Source: KAKEN
Regular physical exercise reduces the risk for obesity, cardiovascular diseases, and disability and is associated with longer lifespan expectancy (Taylor et al., 2004; Pahor et al., 2014; Anton et al., 2015; Arem et al., 2015). In contrast, decreased physical function is associated with hearing loss among older adults (Li et al., 2013; Chen et al., 2015). Here, we investigated the effects of long-term voluntary wheel running (WR) on age-related hearing loss (AHL) in CBA/CaJ mice, a well established model of AHL(Zheng et al., 1999). WR activity peaked at 6 months of age (12,280 m/d) and gradually decreased over time. At 24 months of age, the average WR distance was 3987 m/d. Twenty-four-month-old runners had less cochlear hair cell and spiral ganglion neuron loss and better auditory brainstem response thresholds at the low and middle frequencies compared with age-matched, non-WR controls. Gene ontology (GO) enrichment analysis of inner ear tissues from 6-month-old controls and runners revealed that WR resulted in a marked enrichment for GO gene sets associated with immune response, inflammatory response, vascular function, and apoptosis. In agreement with these results, there was reduced stria vascularis (SV) atrophy and reduced loss of capillaries in the SV of old runners versus old controls. Given that SV holds numerous capillaries that are essential for transporting oxygen and nutrients into the cochlea, our findings suggest that long-term exercise delays the progression of AHL by reducing age-related loss of strial capillaries associated with inflammation.
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