期刊
BIOFOULING
卷 39, 期 1, 页码 1-7出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2022.2160242
关键词
Biofilm; periodontitis; cetylpyridinium chloride
This study evaluated the effectiveness of a mouthwash containing 0.075% cetylpyridinium chloride and 0.28% zinc lactate in controlling a multispecies biofilm. The mouthwash reduced metabolic activity and counts of various harmful bacteria, but did not interfere with beneficial bacteria in relation to the control group. The treatment was effective in controlling periodontal pathogens and promoting health-associated bacterial colonization in the biofilm.
This study evaluated the effect of a mouthwash containing 0.075% cetylpyridinium chloride and 0.28% zinc lactate (CPC + Zn) in a multispecies biofilm model. A 7-days 33-species biofilm, formed on Calgary device, was 1-min treated with: 0.12% chlorhexidine (CHX), culture medium (negative control), 0.075% cetylpyridinium chloride (CPC) or CPC + Zn, 2x/day, from day 3 until day 6. The metabolic activity and the microbial composition were evaluated by colorimetric method and checkerboard DNA-DNA hybridization, respectively. The three antimicrobials (CPC, CPC + Zn and CHX) reduced metabolic activity, total biofilm count and several species counts, including Porphyromonas gingivalis, Fusobacterium nucleatum, Parvimonas micra, Campylobacter gracilis and Streptococcus mutans. However, only CPC + Zn reduced counts of the pathogen Prevotella intermedia and did not interfere with the levels of some beneficial species in relation to the negative control. The treatment of multispecies subgingival biofilm with CPC + Zn was effective in controlling periodontal pathogens and favored the colonization of health-associated bacterial species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据