期刊
BIOESSAYS
卷 45, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/bies.202200118
关键词
DNA methylation; epigenetic inheritance; histone modifications; lipid methylation; non-coding RNAs; rRNA methylation; transgenerational
Heredity is mostly determined by DNA sequences, but some traits are regulated by non-genetic information, known as transgenerational epigenetic inheritance. Studies have shown that changes in epigenetic modifications are correlated with transgenerational phenotypes. Future research in this field aims to establish causal relationships rather than just correlations.
While heredity is predominantly controlled by what deoxyribonucleic acid (DNA) sequences are passed from parents to their offspring, a small but growing number of traits have been shown to be regulated in part by the non-genetic inheritance of information. Transgenerational epigenetic inheritance is defined as heritable information passed from parents to their offspring without changing the DNA sequence. Work of the past seven decades has transitioned what was previously viewed as rare phenomenology, into well-established paradigms by which numerous traits can be modulated. For the most part, studies in model organisms have correlated transgenerational epigenetic inheritance phenotypes with changes in epigenetic modifications. The next steps for this field will entail transitioning from correlative studies to causal ones. Here, we delineate the major molecules that have been implicated in transgenerational epigenetic inheritance in both mammalian and non-mammalian models, speculate on additional molecules that could be involved, and highlight some of the tools which might help transition this field from correlation to causation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据