4.7 Review

Targeted Nanophotoimmunotherapy Potentiates Cancer Treatment by Enhancing Tumor Immunogenicity and Improving the Immunosuppressive Tumor Microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer

Yanan Sun et al.

Summary: The study designed a peptide-photosensitizer conjugate that can release an antagonist peptide at tumor sites to inhibit tumor growth and metastasis.

BIOACTIVE MATERIALS (2023)

Article Chemistry, Multidisciplinary

Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI-Guided Photoimmunotherapy

Hongwei Cheng et al.

Summary: This study presents a novel material system using a glucose and TEMPO copolymer to encapsulate clinical therapeutics and a photosensitizer, achieving targeted therapy and multimodal imaging of tumors. The efficient delivery of the therapeutics leads to antitumor immune activation through photodynamic therapy and CD47 inhibition, reshaping the tumor microenvironment from immunosuppressive to immunoresponsive.

ADVANCED MATERIALS (2022)

Article Biotechnology & Applied Microbiology

Functional nanovesicles displaying anti-PD-L1 antibodies for programmed photoimmunotherapy

Hu Chen et al.

Summary: This study demonstrates a promising strategy for ligand-targeted and personalized cancer photoimmunotherapy by using bone marrow mesenchymal stem cell-derived nanovesicles for targeted drug delivery and photothermal ablation. The selective delivery of photosensitizers and antigen-antibody integrators to tumor tissues significantly improves the efficacy of immunotherapy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Chemistry, Multidisciplinary

Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers

Veronica Almeida-Marrero et al.

Summary: Modifying surfaces with multiple ligands allows for the study of multivalency, which has been successfully demonstrated in the efficient binding of a photosensitizer-nanocarrier system to siglec10. This approach represents a potential method for targeting siglec-expressing cells with photosensitizing nanocarriers.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Chemistry, Multidisciplinary

Photophosphatidylserine Guides Natural Killer Cell Photoimmunotherapy via Tim-3

Xingye Yang et al.

Summary: Researchers have discovered that the binding of phosphatidylserine (PS) to T-cell immunoglobulin and mucin domain containing protein-3 (Tim-3) can inhibit the activation of natural killer (NK) cells. They developed a photoswitchable ligand called photophosphatidylserine (phoPS) which mimics the effects of PS, and demonstrated its ability to modulate the function of NK cells and optically control acute hepatitis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Multidisciplinary Sciences

ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack

Alex T. Ritter et al.

Summary: Cytotoxic T lymphocytes and natural killer cells kill virus-infected and tumor cells through the release of perforin and granzymes. ESCRT proteins are recruited to target cells after perforin release and their inhibition enhances susceptibility to CTL-mediated killing in cancer-derived cells.

SCIENCE (2022)

Article Cell Biology

Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer

Erik Wennerberg et al.

Summary: This study describes ART1-mediated cell death as a mechanism of immune resistance in non-small cell lung cancer and provides preclinical evidence that antibody-mediated targeting of ART1 can improve tumor control.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Review Immunology

Turning cold tumors hot: from molecular mechanisms to clinical applications

Jiahui Zhang et al.

Summary: Immune checkpoint blockade therapies have shown clinical benefit, but many immune-cold solid tumors do not respond. Understanding the mechanisms of cold to hot tumor transition and tumor immunotyping can provide insights for effective therapeutic strategies against cancer.

TRENDS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy

Yuanyuan Guo et al.

Summary: This study presents a rational design and assembly of a nanocarrier that can package multiple drugs, including small-molecule drugs and macromolecular biologics. The nanogel not only achieves photodynamic therapy but also targets gene silencing, leading to enhanced antitumor immune response in a synergistic manner.

SCIENCE ADVANCES (2022)

Article Pharmacology & Pharmacy

Dual-targeting prodrug nanotheranostics for NIR-II fluorescence imaging-guided photo-immunotherapy of glioblastoma

Fenglin Li et al.

Summary: The study presents a dual-targeting nanotheranostic for precise photo-immunotherapy of glioblastoma (GBM). The nanotheranostic can deliver drugs to the tumor site and induce a photothermal effect, enhancing the therapeutic effect.

ACTA PHARMACEUTICA SINICA B (2022)

Article Chemistry, Multidisciplinary

Polymer-Reinforced Liposomes Amplify Immunogenic Cell Death-Associated Antitumor Immunity for Photodynamic-Immunotherapy

Yu Zhao et al.

Summary: An immune-enhancing polymer-reinforced liposome (IERL) with a stable nanostructure and a bioactive surface is developed to enhance antigen cross-presentation and immune cell death-associated antitumor responses.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

Homotypic Targeted Photosensitive Nanointerferer for Tumor Cell Cycle Arrest to Boost Tumor Photoimmunotherapy

Xue-Feng Bai et al.

Summary: Recent advances in tumor immunotherapy primarily focus on remodeling the immunosuppressive tumor microenvironment (TME) to enhance immune responses. However, the complexity of TME limits the effectiveness of single interventions. In this study, we developed a photosensitive nanointerferer that can trigger direct antitumor immune responses by exposing intrinsic features of tumor cells. The nanointerferer delivers a photosensitizer and small interfering RNA to inhibit cyclin-dependent kinase 4 (Cdk4) expression, leading to cell cycle arrest, antigen exposure, and increased expression of programmed cell death protein ligand 1 (PD-L1). Under laser irradiation, the nanointerferer induces photodynamic damage, releases tumor antigens, and recruits dendritic cells (DCs), promoting the activity of CD8(+) T cells in combination with anti-PD-L1 antibodies. This approach effectively inhibits tumor progression in a mouse model without significant adverse effects, providing an alternative treatment option for antitumor immunity.

ACS NANO (2022)

Review Medicine, Research & Experimental

Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond

Danfeng Wei et al.

Summary: NIR-PIT is a newly developed cancer treatment modality that targets tumors using a specific photosensitizer conjugate activated by NIR light. This treatment can induce immunogenic cell death and activate the adaptive immune response, as well as enhance drug delivery into tumors.

THERANOSTICS (2022)

Article Nanoscience & Nanotechnology

Tumor Microenvironment-Regulating Immunosenescence-Independent Nanostimulant Synergizing with Near-Infrared Light Irradiation for Antitumor Immunity

Saji Uthaman et al.

Summary: The combination of photothermal therapy and toll-like receptor-mediated immunotherapy has the potential to activate antitumor immunity and modulate the tumor microenvironment. By utilizing a TLR-5 adjuvant in combination with photothermal therapy, enhanced immune responses can be achieved, impacting the tumor microenvironment for potential therapeutic effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Engineering, Biomedical

Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem

Feifan Zhou et al.

Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.

BIOMATERIALS (2021)

Article Biochemistry & Molecular Biology

In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang et al.

Summary: This study suggests that Cop1 may be a potential target for improving cancer immunotherapy efficacy in TNBC by regulating chemokine secretion and macrophage infiltration in the tumor microenvironment, as demonstrated through experiments in mouse models. This finding highlights the importance of understanding the role of Cop1 in TNBC treatment and its potential implications for enhancing anti-tumor immunity.
Article Chemistry, Multidisciplinary

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

Fang Sun et al.

Summary: The study presents a novel strategy to enhance photoimmunotherapy of pancreatic cancer by provoking T cells activation and overcoming adaptive immune resistance.

ADVANCED SCIENCE (2021)

Article Engineering, Biomedical

Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers

Qi Sun et al.

Summary: The PDA-ICG@CAT-DTA-1 nanosystem overcomes immunosuppression and hypoxia microenvironment to achieve synergism between phototherapy and immunotherapy, promoting potent antitumor effects.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Photodynamic/photothermal therapy enhances neutrophil-mediated ibrutinib tumor delivery for potent tumor immunotherapy: More than one plus one?

Qiujun Qiu et al.

Summary: Neutrophil-mediated drug delivery systems, enhanced by photodynamic/photothermal therapy-induced acute inflammation, have shown improved tumor infiltration and delivery of nanocomplexes, leading to enhanced antitumor T-cell immune responses in cancer therapy.

BIOMATERIALS (2021)

Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.
Article Multidisciplinary Sciences

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion

Xiujie Sun et al.

Summary: The study identifies a new mechanism of immune exclusion mediated by DDR1-ECD through promoting collagen fiber alignment. Inhibition of DDR1 promotes intratumoral penetration of T cells and eradicates tumor growth in TNBC.

NATURE (2021)

Article Chemistry, Multidisciplinary

Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer

Fengqi Zhou et al.

Summary: The study introduces a sequential prodrug nanovesicle designed to enhance drug delivery to tumor tissues and reduce immunological resistance of tumor cells. The nanovesicles show promising results in inhibiting tumor growth and suppressing metastasis in mouse models, providing a new approach for chemoimmunotherapy of cancers by overcoming immune evasion through the IFN-gamma-BRD4-PD-L1 axis.

NANO TODAY (2021)

Article Engineering, Biomedical

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

Xiaoge Zhang et al.

Summary: Photo-immunotherapy using black phosphorus nanoparticles modified with hyaluronic acid shows excellent therapeutic efficacy through combined photothermal and photodynamic therapy, remodeling tumor-associated macrophages and inducing immunogenic cell death. The nanoparticles selectively accumulate at the tumor site and induce antitumor immune responses by releasing DAMPs.

BIOACTIVE MATERIALS (2021)

Article Engineering, Biomedical

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photoimmunotherapy

Zhijin Fan et al.

Summary: This study constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy using metal-organic frameworks, achieving GSH-controlled release of immunoadjuvants and activating the immune system to significantly enhance tumor cytotoxicity, leading to high cure rates.

BIOACTIVE MATERIALS (2021)

Article Oncology

Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity

Shunichi Taki et al.

Summary: The study modified photoimmunotherapy by targeting PD-L1 to enhance anticancer immune system. The therapy showed limited effect on tumor cells in vitro but induced sufficient antitumor effects in vivo, mediated by the 'photoimmuno' effect and antitumor immunity augmentation. The local PD-L1-targeted NIR-PIT enhanced the antitumor immune reaction through direct photonecrotic effect, providing an alternative approach to targeted cancer immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Oncology

Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy

Takuya Kato et al.

Summary: NIR-PIT utilizes an antibody-photoabsorber conjugate activated by NIR light to selectively kill cancer cells with minimal damage to normal cells, while also inducing a therapeutic host immune response. This approach has great potential in treating a variety of cancers and can be used in combination with other immunotherapies for enhanced effect.

CANCERS (2021)

Review Oncology

Oncolysis without viruses - inducing systemic anticancer immune responses with local therapies

Oliver Kepp et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Engineering, Biomedical

Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors

Xuexiang Han et al.

BIOMATERIALS (2020)

Article Biochemistry & Molecular Biology

Tissue Determinants of Human NK Cell Development, Function, and Residence

Pranay Dogra et al.

Article Nanoscience & Nanotechnology

Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy

Dongdong Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Rational Design of a Robust Antibody-like Small-Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

Qi Shang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Chemistry, Multidisciplinary

Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy

Fan Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Biochemistry & Molecular Biology

Targeting tumor-associated macrophages for cancer immunotherapy

Yongheng Shu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

Simona Sivori et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

Review Biotechnology & Applied Microbiology

PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

Yongshuai Jiang et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

Review Chemistry, Multidisciplinary

Near-Infrared Photoimmunotherapy of Cancer

Hisataka Kobayashi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Chemistry, Multidisciplinary

Organic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy

Jingchao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Review Pharmacology & Pharmacy

Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence

Biagio Ricciuti et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Chemistry, Multidisciplinary

Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

Jingchao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Immunology

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets

Meng-Chieh Chiang et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

Article Oncology

Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy

Elodie Picarda et al.

CLINICAL CANCER RESEARCH (2016)

Review Oncology

Myeloid-derived suppressor cells as effectors of immune suppression in cancer

Athalia Rachel Pyzer et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Article Chemistry, Multidisciplinary

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

Hua Gong et al.

NANO LETTERS (2016)

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Editorial Material Urology & Nephrology

Re: Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Timothy J. Daskivich et al.

EUROPEAN UROLOGY (2015)

Review Medicine, Research & Experimental

Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade

Elizabeth Buchbinder et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Chemistry, Multidisciplinary

Nanoparticulate immunotherapy for cancer

Chintan H. Kapadia et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Review Chemistry, Physical

Enhancing photodynamic therapy of refractory solid cancers: Combining second-generation photosensitizers with multi-targeted liposomal delivery

Ruud Weijer et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS (2015)

Review Immunology

Control of adaptive immunity by the innate immune system

Akiko Iwasaki et al.

NATURE IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana et al.

NATURE MEDICINE (2015)

Review Biotechnology & Applied Microbiology

Combination cancer immunotherapy and new immunomodulatory targets

Kathleen M. Mahoney et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Oncology

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

Ivraym B. Barsoum et al.

CANCER RESEARCH (2014)

Review Chemistry, Multidisciplinary

Functional Nanomaterials for Phototherapies of Cancer

Liang Cheng et al.

CHEMICAL REVIEWS (2014)

Review Biochemical Research Methods

Pathogen-like particles: biomimetic vaccine carriers engineered at the nanoscale

Joseph A. Rosenthal et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

Review Oncology

Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

David A. Schaer et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

Review Chemistry, Physical

Engineering synthetic vaccines using cues from natural immunity

Darrell J. Irvine et al.

NATURE MATERIALS (2013)

Review Immunology

Applications of nanotechnology for immunology

Douglas M. Smith et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Cell Biology

Engineering Approaches to Immunotherapy

Melody A. Swartz et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

Makoto Mitsunaga et al.

NATURE MEDICINE (2011)

Review Chemistry, Multidisciplinary

Singlet oxygen: there is indeed something new under the sun

Peter R. Ogilby

CHEMICAL SOCIETY REVIEWS (2010)

Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon et al.

IMMUNITY (2010)

Review Immunology

Neutrophil kinetics in health and disease

Charlotte Summers et al.

TRENDS IN IMMUNOLOGY (2010)

Review Immunology

Current perspectives of natural killer cell education by MHC class I molecules

Petter Hoeglund et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Review Immunology

T Cell Activation

Jennifer E. Smith-Garvin et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Review Engineering, Biomedical

The physics, biophysics and technology of photodynamic therapy

Brian C. Wilson et al.

PHYSICS IN MEDICINE AND BIOLOGY (2008)

Article Medicine, Research & Experimental

VSIG4, a B7 family-related protein, is a negative regulator of T cell activation

Lorenz Vogt et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Pharmacology & Pharmacy

Art and science of photodynamic therapy

S Pervaiz et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)

Review Biochemistry & Molecular Biology

Singlet oxygen oxidation of isolated and cellular DNA: Product formation and mechanistic insights

Jean Cadet et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2006)

Review Biochemistry & Molecular Biology

Reactive species formed on proteins exposed to singlet oxygen

MJ Davies

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2004)

Review Cell Biology

Tryptophan and the immune response

JR Moffett et al.

IMMUNOLOGY AND CELL BIOLOGY (2003)

Review Immunology

T-cell regulation by CD28 and CTLA-4

ML Alegre et al.

NATURE REVIEWS IMMUNOLOGY (2001)

Review Immunology

Nitric oxide and the immune response

C Bogdan

NATURE IMMUNOLOGY (2001)