Hesperidin methyl chalcone ameliorates lipid metabolic disorders by activating lipase activity and increasing energy metabolism

Obesity has become an increasingly serious health issue with the continuous improvement in living standards. Its prevalence has become an economic burden on health care systems worldwide. Flavonoids have been shown to be beneficial in the prevention and treatment of obesity. Here, we evaluated the therapeutic potential of the flavonoid hesperidin methyl chalcone (HMC) on mice with high-fat diet (HFD)-induced hepatic steatosis in vivo and in vitro. Treatment with HMC reduced oleic and palmitic acid-induced increases in intracellular triglyceride accumulation in HepG2, AML12 and LMH cells. HMC also enhanced energy metabolism and lowered oxidative stress. We used Discovery studio to dock key proteins associated with lipid metabolism disorders to HMC, and found that HMC interacted with lipase. Furthermore, we demonstrated that HMC improved lipase activity and lipolysis. In addition, we found that HMC promoted glucose absorption, alleviated lipid metabolic disorders, improved HFD-induced liver injury, and regulated HFD-induced changes in energy metabolism. In conclusion, our study demonstrated that HMC ameliorated HFD-induced obesity and its complications by promoting lipase activity, and provides a novel approach for the prevention and treatment of obesity and related diseases.

Automated summary

Obesity is a serious health issue worldwide, and its prevalence poses an economic burden on healthcare systems. Flavonoids, such as hesperidin methyl chalcone (HMC), have shown therapeutic potential in preventing and treating obesity. In this study, HMC treatment was found to reduce triglyceride accumulation and improve energy metabolism and oxidative stress in cells. Furthermore, HMC enhanced lipase activity, improved lipid metabolic disorders and liver injury, and regulated energy metabolism changes induced by high-fat diet in mice. These findings suggest that HMC provides a novel approach for the prevention and treatment of obesity and related diseases.