4.7 Article

Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Physiology

Sestrin2 ablation attenuates the exercise-induced browning of white adipose tissue in C57BL/6J mice

Lu Wang et al.

Summary: This study reveals the necessity of Sensrin2 in mediating exercise-induced browning of subcutaneous white adipose tissue (scWAT), which affects glucose metabolism and energy expenditure.

ACTA PHYSIOLOGICA (2022)

Review Biochemistry & Molecular Biology

AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration

Zhen Wang et al.

Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain, leading to characteristic pathological changes. Abnormal activity of AMP-activated protein kinase (AMPK) in degenerative disc cells is associated with IDD and regulates crucial biological behaviors in IDD. Therapies targeting AMPK for alleviating IDD are analyzed for potential therapeutic use.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Gastroenterology & Hepatology

Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases

Zhigang Fang et al.

Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

The GATOR2?mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Allison Ho Kowalsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Sestrins are evolutionarily conserved mediators of exercise benefits

Myungjin Kim et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Seung-Hyun Ro et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Physiology

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake

Karla E. Merz et al.

COMPREHENSIVE PHYSIOLOGY (2020)

Review Pharmacology & Pharmacy

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes

Leigh Goedeke et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Review Endocrinology & Metabolism

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Reuben L. Smith et al.

ENDOCRINE REVIEWS (2018)

Review Biochemistry & Molecular Biology

Role of mTOR in Glucose and Lipid Metabolism

Zhuo Mao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Endocrinology & Metabolism

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK

Rasmus Kjobsted et al.

DIABETES (2017)

Review Endocrinology & Metabolism

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

Javier R. Jaldin-Fincati et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Review Cell Biology

Metabolic Flexibility in Health and Disease

Bret H. Goodpaster et al.

CELL METABOLISM (2017)

Article Medicine, Research & Experimental

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

Verena Albert et al.

EMBO MOLECULAR MEDICINE (2016)

Article Multidisciplinary Sciences

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Yuefeng Tang et al.

NATURE COMMUNICATIONS (2016)

Article Endocrinology & Metabolism

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

Xiaolei Liu et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

Article Biochemistry & Molecular Biology

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Hong Yu Wang et al.

BIOCHEMICAL JOURNAL (2013)

Review Biochemistry & Molecular Biology

The multifaceted role of mTORC1 in the control of lipid metabolism

Stephane J. H. Ricoult et al.

EMBO REPORTS (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Cell Biology

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Jun Hee Lee et al.

CELL METABOLISM (2012)

Review Endocrinology & Metabolism

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Bente K. Pedersen et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Review Cell Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Endocrinology & Metabolism

Effects of high-fat diet and regular aerobic exercise on global gene expression in skeletal muscle of C57BL/6 mice

Li Fu et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2012)

Article Biochemistry & Molecular Biology

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells

S. Joha et al.

ONCOGENE (2012)

Article Biochemistry & Molecular Biology

p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling

Andrei V. Budanov et al.

Review Orthopedics

Skeletal Muscle Insulin Resistance: Roles of Fatty Acid Metabolism and Exercise

Lorraine P. Turcotte et al.

PHYSICAL THERAPY (2008)

Article Biochemistry & Molecular Biology

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity

Anil Kumar et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

AV Budanov et al.

ONCOGENE (2002)