期刊
BIOCHEMISTRY-MOSCOW
卷 87, 期 11, 页码 1243-1251出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297922110037
关键词
learning; memory; Irs2; hippocampus; transcriptome; fear conditioning
资金
- Ministry of Science and Education of the Russian Federation [075-15-2020-801]
- Russian Science Foundation [18-75-10112]
Memory formation involves synaptic activity and gene expression changes. The insulin/IGF system plays an important role in neural activation during the early stages of learning.
Memory formation is a complex process involving changes in the synaptic activity and gene expression encoding the insulin-like growth factors. We analyzed changes in the expression of genes encoding the insulin/insulin-like growth factors' proteins at the early period of learning in the CA1 region and dentate gyrus of the dorsal and ventral hippocampus in mice 1 hour after presentation of a new context (contextual fear conditioning) with and without negative reinforcement. It was found that in addition to changes in the expression of immediate early genes c-Fos (in all studied hippocampal fields) and Arc (in dorsal and ventral CA1, as well as in dorsal dentate gyrus), exposure to a new context significantly altered expression of the insulin receptor substrate 2 gene (Irs2) in dorsal CA1 and ventral dentate gyrus irrespectively of the negative reinforcement, which suggests participation of the insulin/IGF system in the early stages of neural activation during learning.
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