4.7 Review

Regulation of blood pressure by natural sulfur compounds: Focus on their mechanisms of action

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

H2S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma

Angela Corvino et al.

Summary: The study focuses on the design and synthesis of molecular hybrids capable of releasing hydrogen sulfide, with the Prednisone-TBZ hybrid showing promising anti-inflammatory properties in reducing allergic asthma symptoms and exacerbations.

JOURNAL OF ADVANCED RESEARCH (2022)

Article Peripheral Vascular Disease

VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery

Jinhua Chen et al.

Summary: The aim of this study was to investigate whether vascular endothelial growth factor receptor 2 (VEGFR(2)) mediates the relaxation effect of hydrogen sulfide (H2S) on the rat cerebral vasculature. The results showed that H2S-induced relaxation and reduction of [Ca2+](i) in vascular smooth muscle cells (VSMCs) occur by acting on VEGFR(2).

MICROVASCULAR RESEARCH (2022)

Article Chemistry, Medicinal

Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide

Lara Testai et al.

Summary: This study demonstrates that Eruca sativa DSM extract has beneficial nutraceutical properties on the cardiovascular system, mainly attributed to its ability to release H2S.

PHYTOTHERAPY RESEARCH (2022)

Article Multidisciplinary Sciences

Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent

Valentina Citi et al.

Summary: A study evaluated the hydrogen sulfide releasing capacity of forty-five isothiocyanates, with 3-pyridyl-isothiocyanate (25) showing promising results. Compound 25 exhibited positive effects in cardioprotection and could be a suitable option for anti-ischemic therapy.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Multidisciplinary Sciences

Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

Valentina Citi et al.

Summary: This review discusses the role of hydrogen sulfide in cardiovascular diseases related to endothelial dysfunction, highlighting its importance as a vasoprotective gasotransmitter in regulating endothelial functionality. Possible therapeutic approaches using molecules able to release H2S are also emphasized.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Chemistry, Medicinal

Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells

Flavia Giordano et al.

Summary: The newly synthesized hybrids with H2S-donor moieties have shown promise in treating asthma by enhancing drug efficacy and reducing toxicity. These compounds modulate multiple targets and release H2S, resulting in inhibiting cell degranulation and inducing cell membrane hyperpolarization.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Obstetrics & Gynecology

Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension

A. G. Langston-Cox et al.

Summary: Sulforaphane, an isothiocyanate found in cruciferous vegetables like broccoli, may serve as an adjuvant therapy for preeclampsia. The bioavailability of sulforaphane differs between non-pregnant women and women with preeclampsia, with higher doses required for pregnant women. Activation of broccoli extract results in better bioavailability of sulforaphane and may improve endothelial function and blood pressure in women with pregnancy hypertension.

REPRODUCTIVE SCIENCES (2021)

Article Medicine, Research & Experimental

The antihypertension effect of hydrogen sulfide (H2S) is induced by activating VEGFR2 signaling pathway

Mo-Li Zhu et al.

Summary: The H2S donor GYY4137 demonstrated significant hypotensive and vascular protective effects in SHR, potentially mediated through regulating VEGFR2 expression and activating the PIP3/Akt signaling pathway, thereby improving vascular endothelial function and promoting endothelial cell proliferation and migration.

LIFE SCIENCES (2021)

Article Food Science & Technology

Maternal Garlic Oil Supplementation Prevents High-Fat Diet-Induced Hypertension in Adult Rat Offspring: Implications of H2S-Generating Pathway in the Gut and Kidneys

Chien-Ning Hsu et al.

Summary: Maternal garlic oil supplementation during pregnancy and lactation can prevent hypertension induced by high-fat diet in adult male offspring, possibly through increased expression and activity of H2S-generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition, showing potential as a reprogramming strategy for hypertension.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Article Pharmacology & Pharmacy

Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway

Haixia Wang et al.

Summary: The study found that in aging rats, remote ischemic preconditioning (RIPC) led to a decrease in cardioprotective effects, which could be restored by hydrogen sulfide (H2S) potentially through upregulating the HIF-1 alpha/Nrf2 signaling pathway.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1

Mark L. Dallas et al.

Summary: Studies have shown that H2S inhibits Kv2.1 channels through S-sulfhydration mechanism, and enhances neuronal excitability. These results highlight an important role for H2S in shaping cellular excitability through S-sulfhydration of Kv2.1 in the central nervous system.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

GYY4137 and Sodium Hydrogen Sulfide Relaxations Are Inhibited by L-Cysteine and KV7 Channel Blockers in Rat Small Mesenteric Arteries

Silvijus Abramavicius et al.

Summary: The study suggests that L-cysteine inhibits relaxations induced by Na2S and GYY4137 by forming sulfides. The rate of release of H2S species from GYY4137 affects the sensitivity of relaxations towards high K+ concentration and potassium channel blockers, indicating a potential beneficial effect of GYY4137 in treating cardiovascular diseases.

FRONTIERS IN PHARMACOLOGY (2021)

Article Food Science & Technology

Effect of garlic powder supplementation on blood pressure and hs-C-reactive protein among nonalcoholic fatty liver disease patients: A randomized, double-blind, placebo-controlled trial

Davood Soleimani et al.

Summary: This study aimed to evaluate the effects of garlic on blood pressure and hs-CRP among NAFLD patients. The results showed significant reductions in blood pressure and hs-CRP in the garlic group, with a positive correlation between changes in hs-CRP and blood pressure.

FOOD SCIENCE & NUTRITION (2021)

Article Pharmacology & Pharmacy

Erucin exhibits vasorelaxing effects and antihypertensive activity by H2S-releasing properties

Alma Martelli et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Organic Isothiocyanates as Hydrogen Sulfide Donors

Alma Martelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Medicine, Research & Experimental

Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms

Tianwei Cui et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Pharmacology & Pharmacy

Anti-inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID-19 therapy

Valentina Citi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats

Fengxia Lin et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Pharmacology & Pharmacy

Role of hydrogen sulfide in cardiovascular ageing

Lara Testai et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Searching for novel hydrogen sulfide donors: The vascular effects of two thiourea derivatives

Valentina Citi et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Cell Biology

Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle

Yuan-Ming Tsai et al.

CELL CALCIUM (2020)

Article Biochemistry & Molecular Biology

Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role

Jovana N. Jeremic et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Pharmacology & Pharmacy

Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma

Giuseppe Ercolano et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemical Research Methods

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

Serena Fortunato et al.

BIOCONJUGATE CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Structural and mechanistic aspects of S-S bonds in the thioredoxin-like family of proteins

Sergio F. Sousa et al.

BIOLOGICAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

Simona Sestito et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Memantine prodrug as a new agent for Alzheimer's Disease

Simona Sestito et al.

SCIENTIFIC REPORTS (2019)

Review Pharmacology & Pharmacy

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

Chadwick R. Powell et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury

Valentina Citi et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors

Beatrice Severino et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity

Emma Mitidieri et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Hydrogen Sulfide (H2S) Releasing Capacity of Isothiocyanates from Moringa oleifera Lam.

Xiangshe Wang et al.

MOLECULES (2018)

Article Biochemistry & Molecular Biology

Allicin relaxes isolated mesenteric arteries through activation of PKA-KATP channel in rat

Shuzhen Li et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2017)

Article Chemistry, Medicinal

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects

Elisabetta Barresi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Cell Biology

Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

Joseph Iharinjaka Randriamboavonjy et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions

Simona Rapposelli et al.

SCIENTIFIC REPORTS (2017)

Review Pharmacology & Pharmacy

H2S-Induced Sulfhydration: Biological Function and Detection Methodology

Da Zhang et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Integrative & Complementary Medicine

Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats

Harikesh Dubey et al.

INTEGRATIVE MEDICINE RESEARCH (2017)

Review Biochemistry & Molecular Biology

S-sulfhydration as a cellular redox regulation

Malgorzata Iciek et al.

BIOSCIENCE REPORTS (2016)

Review Pharmacology & Pharmacy

Using hydrogen sulfide to design and develop drugs

Vincenzo Calderone et al.

EXPERT OPINION ON DRUG DISCOVERY (2016)

Review Endocrinology & Metabolism

Phosphodiesterase type 5 inhibitors: back and forward from cardiac indications

C. Corinaldesi et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Cystathionine beta-synthase regulates endothelial function via protein S-sulfhydration

Sounik Saha et al.

FASEB JOURNAL (2016)

Article Cell Biology

Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease

Ehecatl M. A. Garica-Trejo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Gastroenterology & Hepatology

Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex

Minho Kang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

Ernesto Cuevasanta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Hydrogen sulfide is involved in dexamethasone-induced hypertension in rat

Roberta d'Emmanuele di Villa Bianca et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

H2S: A Novel Gasotransmitter that Signals by Sulfhydration

Bindu D. Paul et al.

TRENDS IN BIOCHEMICAL SCIENCES (2015)

Review Biotechnology & Applied Microbiology

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

Piero Sestili et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemistry & Molecular Biology

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

Sathnur Pushpakumar et al.

CURRENT MEDICINAL CHEMISTRY (2014)

Review Cardiac & Cardiovascular Systems

Cysteine Oxidative Posttranslational Modifications Emerging Regulation in the Cardiovascular System

Heaseung S. Chung et al.

CIRCULATION RESEARCH (2013)

Review Biochemistry & Molecular Biology

Chemical foundations of hydrogen sulfide biology

Qian Li et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

Article Pharmacology & Pharmacy

Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels

A. Martelli et al.

PHARMACOLOGICAL RESEARCH (2013)

Article Chemistry, Medicinal

Arylthioamides as H2S Donors: L-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

Alma Martelli et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Article Pharmacology & Pharmacy

Hydrogen Sulfide as an Allosteric Modulator of ATP-Sensitive Potassium Channels in Colonic Inflammation

Aravind R. Gade et al.

MOLECULAR PHARMACOLOGY (2013)

Review Pharmacology & Pharmacy

The Anti-Oxidant Properties of Isothiocyanates: A Review

Sonia M. de Figueiredo et al.

RECENT PATENTS ON ENDOCRINE METABOLIC & IMMUNE DRUG DISCOVERY (2013)

Review Biochemistry & Molecular Biology

Hydrogen Sulphide: Biopharmacological Roles in the Cardiovascular System and Pharmaceutical Perspectives

A. Martelli et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Review Chemistry, Medicinal

Hydrogen sulphide: novel opportunity for drug discovery

Alma Martelli et al.

MEDICINAL RESEARCH REVIEWS (2012)

Review Physiology

Oxidative modification of proteins: an emerging mechanism of cell signaling

Stephanie B. Wall et al.

FRONTIERS IN PHYSIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels

Guo Hua Liang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

Asif K. Mustafa et al.

CIRCULATION RESEARCH (2011)

Review Urology & Nephrology

Signaling pathways for the vascular effects of hydrogen sulfide

Rui Wang

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2011)

Article Biochemistry & Molecular Biology

Molecular Mechanism for H2S-Induced Activation of KATP Channels

Bo Jiang et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Biochemistry & Molecular Biology

Low Levels of Hydrogen Sulfide in the Blood of Diabetes Patients and Streptozotocin-Treated Rats Causes Vascular Inflammation?

Sushil K. Jain et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Hematology

Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity

Mariarosaria Bucci et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Peripheral Vascular Disease

Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide

Johanna Schleifenbaum et al.

JOURNAL OF HYPERTENSION (2010)

Article Multidisciplinary Sciences

Ingestion of Broccoli Sprouts Does Not Improve Endothelial Function in Humans with Hypertension

Buris Christiansen et al.

PLOS ONE (2010)

Article Biochemistry & Molecular Biology

H2S Signals Through Protein S-Sulfhydration

Asif K. Mustafa et al.

SCIENCE SIGNALING (2009)

Article Gastroenterology & Hepatology

H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels

Nikolai Siebert et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Pharmacology & Pharmacy

Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice

V. Brancaleone et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Multidisciplinary Sciences

Hydrogen sulfide mediates the vasoactivity of garlic

Gloria A. Benavides et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats

H Yan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Plant Sciences

Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat

AM Sharifi et al.

JOURNAL OF ETHNOPHARMACOLOGY (2003)

Article Pharmacology & Pharmacy

Functional roles of KATP channels in vascular smooth muscle

JE Brayden

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2002)

Article Biochemistry & Molecular Biology

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

WM Zhao et al.

EMBO JOURNAL (2001)

Article Peripheral Vascular Disease

The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats

A Elkayam et al.

AMERICAN JOURNAL OF HYPERTENSION (2001)