The role of Notch signaling pathway in metabolic bone diseases

Metabolic bone diseases is the third most common endocrine diseases after diabetes and thyroid diseases. More than 500 million people worldwide suffer from metabolic bone diseases. The generation and development of bone metabolic diseases is a complex process regulated by multiple signaling pathways, among which the Notch signaling pathway is one of the most important pathways. The Notch signaling pathway regulates the differ-entiation and function of osteoblasts and osteoclasts, and affects the process of cartilage formation, bone for-mation and bone resorption. Genetic mutations in upstream and downstream of Notch signaling genes can lead to a series of metabolic bone diseases, such as Alagille syndrome, Adams-Oliver syndrome and spondylocostal dysostosis. In this review, we analyzed the mechanisms of Notch ligands, Notch receptors and signaling mole-cules in the process of signal transduction, and summarized the progress on the pathogenesis and clinical manifestations of bone metabolic diseases caused by Notch gene mutation. We hope to draw attention to the role of the Notch signaling pathway in metabolic bone diseases and provide new ideas and approaches for the diagnosis and treatment of metabolic bone diseases.

Automated summary

Metabolic bone diseases are the third most common endocrine disorders, affecting over 500 million people worldwide. The Notch signaling pathway plays a crucial role in the development and regulation of bone metabolic diseases. Genetic mutations in Notch signaling genes can lead to various metabolic bone diseases. This review provides insights into the mechanisms and clinical manifestations of these diseases, aiming to raise awareness and offer new approaches for diagnosis and treatment of metabolic bone diseases.