期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 635, 期 -, 页码 291-298出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2022.10.027
关键词
Colorectal cancer; CuS NPs; Disulfiram; Photothermal therapy
资金
- National Natural Science Foundation of China [81900287]
- Natural Science Foundation of Xinjiang [2019D01A35]
- Tianshan Youth Foundation of Xinjiang [2019Q066]
This study presents a novel therapeutic nanoplatform, DSF@CuS, which encapsulates DSF in hollow CuS NPs to achieve in situ chemoselective activation of DSF and hyperthermal amplified chemotherapy. The combination of DSF@CuS and photothermal therapy significantly promotes apoptosis of CT26 colorectal cancer cells both in vitro and in vivo.
Colorectal cancer is one of the most common malignancies causing the majority of cancer-related deaths. There is an urgent need to develop new anticancer modalities. Recently, efforts have been made to turn clinically approved drugs into anticancer agents in specific tumor microenvironments via NPs. Disulfiram (DSF) as an effective copper ( Cu2thorn)-dependent anti-tumour drug, which has been more widely used in antitumor research. Here, we constructed a novel therapeutic nanoplatforms, DSF@CuS, by encapsulating DSF in hollow CuS NPs to enable in situ chemoselective activation of DSF and hyperthermal amplified chemotherapy. The anticancer effect of DSF was enhanced by the thermal energy generated under NIR irradiation through the intrinsic photothermal conversion of CuS. As a result, significant apoptosis was induced in vitro, and tumor elimination was achieved in vivo. Collectively, DSF@CuS combined with photothermal therapy can significantly promote the apoptosis of CT26 colorectal cancer cells both in vitro and in vivo, providing a potential theoretical agent for the treatment of colorectal cancer. (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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