Rethinking the visceral innervation - Peek into the emerging field of molecular dissection of neural signals

Article Multidisciplinary Sciences

Sensory representation and detection mechanisms of gut osmolality change

Takako Ichiki et al.

Summary: This study reveals that gastrointestinal sensory neurons detect visceral hypoosmolality and transmit hormonal signals to regulate thirst circuit activity through the hepatic portal area (HPA) pathway.

NATURE (2022)

添加到收藏夹

Article Neurosciences

Neuron-derived neuropeptide Y fine-tunes the splenic immune responses

Jinsong Yu et al.

Summary: The nervous and immune systems are connected, with NPY playing a role in regulating immune responses and immune balance. This ancient language of communication between the nervous and immune systems could potentially be utilized to alleviate inflammation during infection and modulate immune balance in autoimmune diseases.

NEURON (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin

Yuta Yoshioka et al.

Summary: This study reveals that the Uts2b gene is expressed in a microbiota-dependent manner in vagal afferent neurons and is associated with the transmission of sensory information from CCK-expressing EECs to the brain.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A multidimensional coding architecture of the vagal interoceptive system

Qiancheng Zhao et al.

Summary: This study reveals a multidimensional coding architecture of the mammalian vagal interoceptive system, in which VSNs code signals in different dimensions such as visceral organs, tissue layers, and stimulus modalities, enabling complex projections of VSNs in the brainstem.

NATURE (2022)

添加到收藏夹

Article Allergy

FcεR1-expressing nociceptors trigger allergic airway inflammation

Theo Crosson et al.

Summary: Research identified that lung nociceptor neurons amplify immune cell activity and mucus metaplasia in response to an inhaled allergen challenge. By investigating the direct response of neurons to allergens and the effects of nociceptor-specific Fc epsilon R1 gamma knockdown, a feedforward inflammatory loop was revealed in allergic inflammation triggered by allergen sensitization.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

Jussi Kupari et al.

Summary: This study classified non-human primate dorsal root ganglion sensory neurons based on their transcriptome and mapped human pain heritability to neuronal types. The findings revealed the cellular origin of chronic pain by showing genome-wide associations converging on two different neuronal types with different genetic susceptibilities for chronic pain.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biology

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Minh Q. Nguyen et al.

Summary: Through single nuclear transcriptomics of human DRG neurons, it was found that different types of neurons share similarities in their transcriptomic features, but there are species differences in the expression of genes related to sensory function. Surprisingly, several transcriptomic classes without clear equivalents in other species were identified.

ELIFE (2021)

添加到收藏夹

Article Cell Biology

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

Diba Borgmann et al.

Summary: Distinct gut-innervating sensory neurons play differential roles in controlling feeding and glucoregulation, with some vagal afferents influencing meal termination and glucose tolerance through GLP1R activation, while others mainly regulate hepatic glucose production and normoglycemia through GPR65 expression.

CELL METABOLISM (2021)

添加到收藏夹

Article Neurosciences

Highly selective brain-to-gut communication via genetically defined vagus neurons

Jenkang Tao et al.

Summary: The study revealed seven molecularly distinct subtypes of motor neurons within the vagus nerve, with two of them exclusively innervating the glandular domain of the stomach and contacting enteric neurons releasing functionally opposing neurotransmitters. This discovery demonstrates a division of labor within the parasympathetic nervous system to control autonomic function.

NEURON (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology