Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice

Article Biochemistry & Molecular Biology

Maternal sevoflurane exposure disrupts oligodendrocyte myelination of the postnatal hippocampus and induces cognitive and motor impairments in offspring

Ze Fan et al.

Summary: Maternal exposure to sevoflurane anesthesia during pregnancy can have detrimental effects on the cognitive and motor functions of offspring, possibly due to impaired myelination.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Endocrinology & Metabolism

Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation

Lirong Liang et al.

Summary: Recent studies have shown that melatonin pretreatment significantly alleviated the synaptic deficiency, dysmyelination, and long-term learning impairment induced by neonatal repeated exposure to Sev. The protective effects of melatonin on synaptic development, myelination, and behavior performance were mediated by the MT1 receptor and involved the canonical Wnt signaling pathway. This suggests that melatonin may be a promising clinical intervention for improving the safety of pediatric Sev anesthesia.

JOURNAL OF PINEAL RESEARCH (2021)

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Article Multidisciplinary Sciences

The effects of the general anesthetic sevoflurane on neurotransmission: an experimental and computational study

Jonathan Mapelli et al.

Summary: The general anesthetic sevoflurane alters neurotransmission by increasing GABAergic inhibition and decreasing glutamatergic NMDA activity, leading to changes in neuronal communication without silencing neural circuits. The drug also affects the intrinsic excitability of cerebellar granule cells by promoting action potential generation through modulation of ion currents.

SCIENTIFIC REPORTS (2021)

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Review Cell Biology

Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair

Daniel Reyes-Haro et al.

Summary: Oligodendrocytes play a crucial role in brain connectivity by producing myelin for insulating axons. Myelin repair relies on the differentiation of new oligodendrocytes from precursor cells to preserve and remodel myelin. Neuron-glia communication through GABA signaling in OPCs is important for myelin plasticity and repair.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Immunology

Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis

Jing Dai et al.

Summary: The study revealed that repeated sevoflurane exposure in developing rats may induce neuroinflammation and neurocognitive impairment through NF-kappa B-mediated pyroptosis activation. This suggests a potential therapeutic target in treating neuroinflammation following neonatal anesthesia.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Neurosciences