4.6 Article

FOXO1 represses PPARa-Mediated induction of FGF21 gene expression

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Summary: Fgf21 plays a crucial role in regulating metabolism during hepatic insulin resistance, as shown by studies where modestly reduced Fgf21 due to hepatic FoxO1 suppression contributed to metabolic dysregulation in LDKO mice. Restoring Fgf21 through adenoviral infection corrected metabolic issues in the mice, highlighting the importance of Fgf21-dependent plasticity and BAT function in metabolic health.

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