Functionalization of imidazole N-oxide: a recent discovery in organic transformations

Nowadays heterocyclic compounds are widely used in medicinal chemistry and industry to develop life-saving drugs and medi-cines. Imidazole is one of the pharmacologically important heterocyclic motifs found in widely used and well-known medicines and bioactive molecules. The applications of imidazole derivatives displaying various biological activities, motivated researchers for the development of more potent and significant drugs containing imidazole moieties. The formation of imidazole derivatives can be achieved using imidazole N -oxide as starting material. In this review, the scope of substrates and reaction mechanisms of various synthetic approaches using imidazole N -oxides as substrates are summarized so that the chemists, researchers, and pharmaceutical industries find its effectiveness in near future for the synthesis of potent, novel, and non-toxic drug molecules.

Automated summary

Heterocyclic compounds, especially imidazole derivatives, have been extensively used in medicinal chemistry and industry for the development of potent drugs and medicines. This review summarizes various synthetic approaches and reaction mechanisms using imidazole N-oxides as substrates, providing valuable guidance for chemists, researchers, and pharmaceutical industries in the synthesis of effective and novel drug molecules.