期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 18, 期 -, 页码 1589-1595出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.18.169
关键词
benzo[c]phenanthridine alkaloids; 1; 5-enyne; formal total synthesis; gold catalysis; macarpine
资金
- National Natural Science Foundation of China [21977073]
- Natural Science Foundation of Liaoning, China [2022 -MS -245]
- Liaoning Provincial Foundation of Educational Department [LJKZ0908]
- Program for the Innovative Research Team of the Ministry of Education
- Program for the Liaoning Innovative Research Team in University
The formal total synthesis of macarpine was achieved by constructing a naphthol intermediate using two different synthetic routes in Ishikawa's synthetic route. The convergent synthetic strategies involved the use of Au(I)-catalyzed cycloisomerization reactions of 1,5-enyne and alkynyl ketone substrates prepared via Sonogashira coupling reactions.
The formal total synthesis of macarpine was accomplished by the construction of a naphthol intermediate in Ishikawa's synthetic route with two different synthetic routes. The convergent synthetic strategies feature the utilization of Au(I)-catalyzed cycloisomer-izations of a 1,5-enyne and alkynyl ketone substrates, which were prepared by Sonogashira coupling reactions.
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