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AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics

AUTOPHAGY (2023)

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+T cell proliferation

Dingxi Zhou et al.

Summary: This study identifies interleukin-7 receptor-alpha as a key cargo in proliferating CD4+ T cells within the autophagosomal compartment using a transgenic mouse model. Moreover, the authors uncover the mechanism by which excessive surface interleukin-7 receptor-alpha affects T cell proliferation.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

The Proteomic Landscape of Resting and Activated CD4+T Cells Reveal Insights into Cell Differentiation and Function

Yashwanth Subbannayya et al.

Summary: This study conducted label-free high-resolution proteomic profiling of resting and activated CD4+ T cells, identifying significant alterations in the levels of numerous proteins and observed changes in stimulatory/inhibitory immune checkpoint markers between the two states. Network analysis revealed regulatory hubs of CD4+ T cell activation, and comparisons with other cell types indicated interspecies proteomic differences.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

Adaptive immunity at the crossroads of autophagy and metabolism

Shree Padma Metur et al.

Summary: The function of lymphocytes relies on their plasticity in response to energy availability and environmental stress, as well as their protein synthesis machinery. Autophagy, as the primary metabolic pathway, helps cells overcome stress and regulates the metabolism of adaptive immune cells. The versatile roles of autophagy in cellular metabolism have important implications for immune cell function and fate, particularly for T and B lymphocytes.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

Francois Le Guerroue et al.

MOLECULAR CELL (2017)

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Article Immunology

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

Vanessa M. Hubbard et al.

JOURNAL OF IMMUNOLOGY (2010)

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Review Immunology

Contributions to our understanding of T cell physiology through unveiling the T cell proteome

M. M. Grant et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2007)

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AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics

相关参考文献

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+T cell proliferation

The Proteomic Landscape of Resting and Activated CD4+T Cells Reveal Insights into Cell Differentiation and Function

Adaptive immunity at the crossroads of autophagy and metabolism

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

Contributions to our understanding of T cell physiology through unveiling the T cell proteome

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