期刊
AUTOPHAGY
卷 19, 期 3, 页码 745-746出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2022.2161154
关键词
Autophagy; cargo; mass spectrometry; proliferation; purification; T cells
类别
Autophagy is a cellular process that breaks down cellular components and is important in events where cell composition changes. It is involved in T cell regulation, particularly in the activation of helper T cells. Autophagy facilitates the breakdown of cellular components during the activation of CD4(+) T cells, and further research is needed to understand how this induced autophagy affects CD4(+) T cell proliferation and function.
Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regulation including maintaining cell homeostasis. One process where a cell alters its composition is in the activation of helper T cells in the immune system. When helper (CD4(+)) T cells are activated by antigens, they both grow and alter their cellular components to become effector T cells. Autophagy is the process that facilitates the breakdown of these cellular components and is therefore hypothesized to have a role in CD4(+) T cell activation. Previous research has concluded that CD4(+) T cell activation induces autophagy, providing an avenue for further research aimed at examining the ways in which this induced autophagy affects CD4(+) T cell proliferation and function. Toward this end, Zhou et al. researched the autophagosomal cargo present within CD4(+) T cells and the impact this cargo has on CD4(+) T cell proliferation.
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