Where is the field of autophagy research heading?

Review Cell Biology

The pleiotropic functions of autophagy in metastasis

Timothy Marsh et al.

Summary: Autophagy plays complex roles in cancer metastasis, affecting therapeutic approaches. It can both promote tumor growth and drug resistance, as well as inhibit the proliferation of disseminated tumor cells to form metastases.

JOURNAL OF CELL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

Susanne Zellner et al.

Summary: The study investigates the formation of protein aggregates in fed conditions due to autophagy deficiency and the contribution of selective autophagy pathways to cellular proteostasis. Different receptors and substrates of aggrephagy are identified, with a systematic mapping of the autophagic degradome targeted by UBD-containing receptors under basal and proteostasis-challenging conditions.

MOLECULAR CELL (2021)

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Review Multidisciplinary Sciences

Emerging technologies and infection models in cellular microbiology

Ana Teresa Lopez-Jimenez et al.

Summary: Cellular microbiology, a field that studies intracellular pathogens and their manipulation of host cells, has seen recent advances in technologies and infection models that are driving the development of new strategies for combating infections and improving human health. A focus on microscopy, robotics, artificial intelligence, and advanced imaging techniques has led to a deeper understanding of the host-pathogen interface and the infection process within cells, offering promising opportunities for future medical advancements.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress

Inna Rabinovich-Nikitin et al.

Summary: This study reveals that the CLOCK gene transcriptionally coordinates mitochondrial quality control mechanisms in cardiac myocytes, regulating an adaptive stress response crucial for cell survival. Restoring CLOCK activity may be beneficial in reducing cardiac injury in individuals with disrupted circadian rhythms.

AUTOPHAGY (2021)

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Review Biochemistry & Molecular Biology

Autophagy in liver diseases: A review

Hui Qian et al.

Summary: The liver is a crucial metabolic organ, where autophagy plays a significant role in maintaining cellular and metabolic homeostasis. Autophagy in the liver fluctuates with hormonal cues, nutrient availability, and circadian activities. Dysfunctional autophagy may lead to various liver diseases.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Review Endocrinology & Metabolism

Autophagy in metabolic disease and ageing

Munehiro Kitada et al.

Summary: Dysfunctional autophagy can lead to various diseases, particularly age-related metabolic derangements such as insulin resistance, type 2 diabetes mellitus, and sarcopenic obesity. The decline in autophagic efficiency with age and the interference of overnutrition can exacerbate these conditions by accumulating damaged cellular components. Developing autophagy-based therapies may hold potential in treating metabolic diseases associated with aging.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Oncology

Autophagy in tumour immunity and therapy

Houjun Xia et al.

Summary: Autophagy plays a crucial role in cancer by influencing tumor progression, immune responses, and therapy outcomes. Modulating the autophagy pathway can enhance antitumor immune responses and improve treatment efficacy.

NATURE REVIEWS CANCER (2021)

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Review Biochemistry & Molecular Biology