期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 26, 页码 6926-6936出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0307-16.2016
关键词
in vivo recording; mPFC; object recognition; social interaction; three chamber test
资金
- Institute for Basic Science Grants [IBS-R002-D1, IBS-R002-G1]
Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known about mPFC neural correlates of social behavior. In the present study, we examined single-neuron activity in the mPFC of mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations of mPFC neural processes underlying social interaction in health and disease.
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